中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2015年
23期
113-116
,共4页
高尿酸血症%老年人%认知功能障碍%相关性
高尿痠血癥%老年人%認知功能障礙%相關性
고뇨산혈증%노년인%인지공능장애%상관성
Hyperuricemia%Elderly people%Cognitive dysfunction%Correlation
目的:探讨老年人认知功能障碍与高尿酸血症的相关性。方法选取2010年1月~2014年1月在深圳市宝安区人民医院(以下简称“我院”)住院或门诊就医的老年认知功能障碍患者200例,分为轻度认知障碍组100例,痴呆组100例,另选取我院同期健康体检老年人100例作为对照组,比较3组血尿酸水平,并对可能影响认知功能的因素,如高尿酸血症以及年龄、受教育程度、吸烟史、饮酒史、高血压、血糖、血脂等指标引入Logistic回归分析,判断高尿酸血症对认知功能障碍的影响。结果轻度认知功能障碍组[(365.9±38.7)μmol/L]与痴呆组[(421.3±43.0)μmol/L]血尿酸水平高于对照组[(237.5±40.2)μmol/L],痴呆组血尿酸水平高于轻度认知功能障碍组,差异均有统计学意义(均P<0.05)。 Logistic回归分析显示,高尿酸血症是认知功能障碍的危险因素(OR =2.944,P<0.05)。结论高尿酸血症是老年人认知功能障碍的危险因素,且认知功能障碍程度与血尿酸水平相关。
目的:探討老年人認知功能障礙與高尿痠血癥的相關性。方法選取2010年1月~2014年1月在深圳市寶安區人民醫院(以下簡稱“我院”)住院或門診就醫的老年認知功能障礙患者200例,分為輕度認知障礙組100例,癡呆組100例,另選取我院同期健康體檢老年人100例作為對照組,比較3組血尿痠水平,併對可能影響認知功能的因素,如高尿痠血癥以及年齡、受教育程度、吸煙史、飲酒史、高血壓、血糖、血脂等指標引入Logistic迴歸分析,判斷高尿痠血癥對認知功能障礙的影響。結果輕度認知功能障礙組[(365.9±38.7)μmol/L]與癡呆組[(421.3±43.0)μmol/L]血尿痠水平高于對照組[(237.5±40.2)μmol/L],癡呆組血尿痠水平高于輕度認知功能障礙組,差異均有統計學意義(均P<0.05)。 Logistic迴歸分析顯示,高尿痠血癥是認知功能障礙的危險因素(OR =2.944,P<0.05)。結論高尿痠血癥是老年人認知功能障礙的危險因素,且認知功能障礙程度與血尿痠水平相關。
목적:탐토노년인인지공능장애여고뇨산혈증적상관성。방법선취2010년1월~2014년1월재심수시보안구인민의원(이하간칭“아원”)주원혹문진취의적노년인지공능장애환자200례,분위경도인지장애조100례,치태조100례,령선취아원동기건강체검노년인100례작위대조조,비교3조혈뇨산수평,병대가능영향인지공능적인소,여고뇨산혈증이급년령、수교육정도、흡연사、음주사、고혈압、혈당、혈지등지표인입Logistic회귀분석,판단고뇨산혈증대인지공능장애적영향。결과경도인지공능장애조[(365.9±38.7)μmol/L]여치태조[(421.3±43.0)μmol/L]혈뇨산수평고우대조조[(237.5±40.2)μmol/L],치태조혈뇨산수평고우경도인지공능장애조,차이균유통계학의의(균P<0.05)。 Logistic회귀분석현시,고뇨산혈증시인지공능장애적위험인소(OR =2.944,P<0.05)。결론고뇨산혈증시노년인인지공능장애적위험인소,차인지공능장애정도여혈뇨산수평상관。
Objective To explore correlation between cognitive dysfunction and hyperuricemia in elderly people. Methods 200 cases of elderly patients in Bao'an District People’s Hospital of Shenzhen City (“our hospital”for short) from January 2010 to January 2014 were selected and divided into 2 groups, with 100 cases in mild cognitive dysfunc-tion group and 100 cases in dementia group. Another 100 healthy elderly people with physical examination in our hos-pital were selected as control group. The blood uric acid levels of the three groups were compared, and possible factors related with cognitive function like hyperuricemia, age, education level, smoking history, drinking history, high blood pressure, blood glucose and blood lipid were analyzed by Logistic regression in order to determine effects of hyperuricemia on cognitive dysfunction. Results The blood uric acid level in mild cognitive dysfunction group [(365.9±38.7) μmol/L] and dementia group [(421.3±43.0)μmol/L] was higher than that in control group[(237.5±40.2) μmol/L] respectively, and the blood uric acid level in dementia group was higher than that in mild cognitive dysfunction group, with statistically significant difference (all P<0.05). Logistic regression showed that hyperuricemia was the risk factor of cognitive dys-function (OR =2.944, P<0.05). Conclusion Hyperuricemia is the risk factor of cognitive dysfunction in elderly peo-ple, and the degree of cognitive dysfunction relates with uric acid level.