中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2015年
7期
612-616
,共5页
糖尿病周围神经病变%血清基质细胞衍生因子-1α%鼠神经生长因子
糖尿病週圍神經病變%血清基質細胞衍生因子-1α%鼠神經生長因子
당뇨병주위신경병변%혈청기질세포연생인자-1α%서신경생장인자
Diabetic peripheral neuropathy(DPN)%Stromal cell-derived factor-1α(SDF-1α)%Mouse never growth factor(MNGF)
目的:探讨糖尿病周围神经病变(DPN)患者血清基质细胞衍生因子‐1α(SDF‐1α)水平改变及鼠神经生长因子(M NGF)对其影响。方法选取 T2DM 患者180例,根据有无DPN分为DPN组92例和T2DM未合并DPN (T2DM )组88例。另选同期体检健康者90名作为健康对照(NC)组。将DPN组进一步分为MNGF治疗(A)亚组47例和基础治疗(B)亚组45例。检测各组血清SDF‐1α水平,分析其与超氧化物歧化酶(SOD)、转化生长因子‐β1(TGF‐β1)、高敏C反应蛋白(hsC‐RP)、神经生长相关蛋白‐43(GAP‐43)的关系。观察MNGF治疗前后两亚组血清SDF‐1α水平的变化。结果血清SDF‐1α水平由低到高依次为NC、DPN、T2DM组[(0.91±0.37) vs (1.71±0.43) vs (2.58±0.58)μg/L ,P<0.05或 P<0.01]。Pearson相关性分析结果显示,T2DM组血清SDF‐1α水平与 FPG、HbA1 c、TGF‐β1和hsC‐RP呈正相关,与SOD呈负相关;DPN组血清SDF‐1α水平与TG、TGF‐β1呈正相关,与病程、FPG、HbA1 c、SOD、hsC‐RP、GAP‐43、正中神经运动神经传导速度(MMCV)、腓总神经运动神经传导速度(PMCV)、正中神经感觉神经传导速度(MSCV)、腓总神经感觉神经传导速度(PSCV)呈负相关。A亚组血清SDF‐1α水平治疗后较治疗前升高[(1.75±0.39)vs(2.09±0.45)μg/L,P<0.05],B亚组治疗后与治疗前比较差异无统计学意义[(1.67±0.48) vs (1.71±0.51)μg/L ,P>0.05]。多元逐步回归分析结果显示, HbA1c、hsC‐RP和腓总神经感觉神经传导速度(PSCV)是SDF‐1α的影响因素。结论 DPN患者SDF‐1α水平较T2DM患者低,M NGF增加血清SDF‐1α水平。
目的:探討糖尿病週圍神經病變(DPN)患者血清基質細胞衍生因子‐1α(SDF‐1α)水平改變及鼠神經生長因子(M NGF)對其影響。方法選取 T2DM 患者180例,根據有無DPN分為DPN組92例和T2DM未閤併DPN (T2DM )組88例。另選同期體檢健康者90名作為健康對照(NC)組。將DPN組進一步分為MNGF治療(A)亞組47例和基礎治療(B)亞組45例。檢測各組血清SDF‐1α水平,分析其與超氧化物歧化酶(SOD)、轉化生長因子‐β1(TGF‐β1)、高敏C反應蛋白(hsC‐RP)、神經生長相關蛋白‐43(GAP‐43)的關繫。觀察MNGF治療前後兩亞組血清SDF‐1α水平的變化。結果血清SDF‐1α水平由低到高依次為NC、DPN、T2DM組[(0.91±0.37) vs (1.71±0.43) vs (2.58±0.58)μg/L ,P<0.05或 P<0.01]。Pearson相關性分析結果顯示,T2DM組血清SDF‐1α水平與 FPG、HbA1 c、TGF‐β1和hsC‐RP呈正相關,與SOD呈負相關;DPN組血清SDF‐1α水平與TG、TGF‐β1呈正相關,與病程、FPG、HbA1 c、SOD、hsC‐RP、GAP‐43、正中神經運動神經傳導速度(MMCV)、腓總神經運動神經傳導速度(PMCV)、正中神經感覺神經傳導速度(MSCV)、腓總神經感覺神經傳導速度(PSCV)呈負相關。A亞組血清SDF‐1α水平治療後較治療前升高[(1.75±0.39)vs(2.09±0.45)μg/L,P<0.05],B亞組治療後與治療前比較差異無統計學意義[(1.67±0.48) vs (1.71±0.51)μg/L ,P>0.05]。多元逐步迴歸分析結果顯示, HbA1c、hsC‐RP和腓總神經感覺神經傳導速度(PSCV)是SDF‐1α的影響因素。結論 DPN患者SDF‐1α水平較T2DM患者低,M NGF增加血清SDF‐1α水平。
목적:탐토당뇨병주위신경병변(DPN)환자혈청기질세포연생인자‐1α(SDF‐1α)수평개변급서신경생장인자(M NGF)대기영향。방법선취 T2DM 환자180례,근거유무DPN분위DPN조92례화T2DM미합병DPN (T2DM )조88례。령선동기체검건강자90명작위건강대조(NC)조。장DPN조진일보분위MNGF치료(A)아조47례화기출치료(B)아조45례。검측각조혈청SDF‐1α수평,분석기여초양화물기화매(SOD)、전화생장인자‐β1(TGF‐β1)、고민C반응단백(hsC‐RP)、신경생장상관단백‐43(GAP‐43)적관계。관찰MNGF치료전후량아조혈청SDF‐1α수평적변화。결과혈청SDF‐1α수평유저도고의차위NC、DPN、T2DM조[(0.91±0.37) vs (1.71±0.43) vs (2.58±0.58)μg/L ,P<0.05혹 P<0.01]。Pearson상관성분석결과현시,T2DM조혈청SDF‐1α수평여 FPG、HbA1 c、TGF‐β1화hsC‐RP정정상관,여SOD정부상관;DPN조혈청SDF‐1α수평여TG、TGF‐β1정정상관,여병정、FPG、HbA1 c、SOD、hsC‐RP、GAP‐43、정중신경운동신경전도속도(MMCV)、비총신경운동신경전도속도(PMCV)、정중신경감각신경전도속도(MSCV)、비총신경감각신경전도속도(PSCV)정부상관。A아조혈청SDF‐1α수평치료후교치료전승고[(1.75±0.39)vs(2.09±0.45)μg/L,P<0.05],B아조치료후여치료전비교차이무통계학의의[(1.67±0.48) vs (1.71±0.51)μg/L ,P>0.05]。다원축보회귀분석결과현시, HbA1c、hsC‐RP화비총신경감각신경전도속도(PSCV)시SDF‐1α적영향인소。결론 DPN환자SDF‐1α수평교T2DM환자저,M NGF증가혈청SDF‐1α수평。
Objective To investigate the changes of serum stromal cell‐derived factor‐1α (SDF‐1α) in patients with diabetic peripheral neuropathy (DPN) and the influence of mouse never growth factor (MNGF) on the levels of serum SDF‐1α. Methods 180 patients with type 2 diabetes (T2DM ) were divided into T2DM with DPN (DPN group ,n=92) and T2DM without DPN (T2DM group ,n=88). 90 healthy people were select as normal control (NC group). DPN group was divided into 47 cases of MNGF treatment (A) subgroup and 45 cases of basic treatment (B) subgroup. The levels of serum SDF‐1αwere measured using ELISA method. The relationships between the levels of serum SDF‐1αand SOD ,TGF‐β1 , hsC‐RP ,and GAP‐43 were analyzed. After treatment ,the levels of serum SDF‐1α in A and B subgroups were compared. Results Compared with NC group [(0.91 ± 0.37)μg/L] ,the levels of serum SDF‐1αin T2DM and DPN group were higher [(2.58 ± 0.58) μg/L and(1.71 ± 0.43)μg/L ,respectively ,P<0.05 or P<0.01]. The levels of SDF‐1αwere positively correlated with FPG ,HbA1 c ,TGF‐β1 and hsC‐RP ,and negatively correlated with SOD in T2DM group. The levels of SDF‐1αwere positively correlated with TG and TGF‐β1 ,and negatively correlated with course of disease ,FPG ,HbA1 c ,SOD ,hsC‐RP ,GAP‐43 , MMCV ,PMCV ,MSCV and PSCV in DPN group. SDF‐1α levels were significantly increased after treatment with MNGF in subgroup A [(1.75 ± 0.39) vs (2.09 ± 0.45)μg/L ,P<0.05]. There were no significant difference of SDF‐1αlevels after treatment in subgroup B [(1.67 ± 0.48) vs (1.71 ± 0.51)μg/L , P>0.05] .Multiple stepwise regression analysis showed that HbA1c ,hsC‐RP and PSCV were the independent factors related with the levels of SDF‐1αin DPN patients. Conclusion The levels of serum SDF‐1αin DPN patients are lower than in T2DM patients without DPN. MNGF may increase the level of serum SDF‐1α.