中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2015年
23期
79-82
,共4页
结直肠癌%辅助化疗%临床疗效%预后
結直腸癌%輔助化療%臨床療效%預後
결직장암%보조화료%림상료효%예후
Colorectal cancer%Assistant chemotherapy%Clinical efficacy%Prognosis
目的：探讨结直肠癌根治术后行FOLFOX4与5-FU/LV辅助化疗方案的远期疗效。方法选择四川省眉山市第二人民医院2011年12月~2014年5月收治的63例结直肠癌根治术后患者为研究对象,根据化疗方案的不同将其分为试验组30例和对照组33例,其中对照组术后给予5-FU/LV辅助化疗,试验组术后行FOLFOX4方案化疗,两组患者至少接受4个周期的化疗方案。分析比较两组患者生存时间及化疗不良反应。结果两组患者随访12~40个月,中位随访时间为28.1个月。试验组中位生存时间为30.2个月,对照组为22.3个月,两组患者中位生存时间经Log-rank检验显示,试验组显著高于对照组(HR =1.87,95%CI院1.06~3.64,P<0.05)。两组患者主要不良反应为1~2级胃肠道反应。结论 FOLFOX4化疗方案用于结直肠癌根治术后辅助化疗可显著延长患者中位生存时间,且不增加不良反应。
目的：探討結直腸癌根治術後行FOLFOX4與5-FU/LV輔助化療方案的遠期療效。方法選擇四川省眉山市第二人民醫院2011年12月~2014年5月收治的63例結直腸癌根治術後患者為研究對象,根據化療方案的不同將其分為試驗組30例和對照組33例,其中對照組術後給予5-FU/LV輔助化療,試驗組術後行FOLFOX4方案化療,兩組患者至少接受4箇週期的化療方案。分析比較兩組患者生存時間及化療不良反應。結果兩組患者隨訪12~40箇月,中位隨訪時間為28.1箇月。試驗組中位生存時間為30.2箇月,對照組為22.3箇月,兩組患者中位生存時間經Log-rank檢驗顯示,試驗組顯著高于對照組(HR =1.87,95%CI院1.06~3.64,P<0.05)。兩組患者主要不良反應為1~2級胃腸道反應。結論 FOLFOX4化療方案用于結直腸癌根治術後輔助化療可顯著延長患者中位生存時間,且不增加不良反應。
목적：탐토결직장암근치술후행FOLFOX4여5-FU/LV보조화료방안적원기료효。방법선택사천성미산시제이인민의원2011년12월~2014년5월수치적63례결직장암근치술후환자위연구대상,근거화료방안적불동장기분위시험조30례화대조조33례,기중대조조술후급여5-FU/LV보조화료,시험조술후행FOLFOX4방안화료,량조환자지소접수4개주기적화료방안。분석비교량조환자생존시간급화료불량반응。결과량조환자수방12~40개월,중위수방시간위28.1개월。시험조중위생존시간위30.2개월,대조조위22.3개월,량조환자중위생존시간경Log-rank검험현시,시험조현저고우대조조(HR =1.87,95%CI원1.06~3.64,P<0.05)。량조환자주요불량반응위1~2급위장도반응。결론 FOLFOX4화료방안용우결직장암근치술후보조화료가현저연장환자중위생존시간,차불증가불량반응。
Objective To evaluate the long term efficacy of adjuvant chemotherapy regimens of FOLFOX4 and 5-FU/LV after radical resection for colorectal cancer. Methods 63 patients after radical resection for colorectal cancer admit-ted to the Second People's Hospital of Meishan City from December 2011 to May 2014 were selected as research ob-jects, and they were divided into experiment group (30 cases) and control group (33 cases) according to the difference of chemotherapy regimens. The patients in the control group were treated with 5-FU/LV adjuvant chemotherapy regi-men after operation and patients in the experiment group were treated with FOLFOX4 chemotherapy regimen after op-eration. All of the enrolled patients received at least 4 cycles treatment regimen. The survival time and chemotherapy side effects were analyzed and compared between the two groups. Results The follow up period of the two groups was 12-40 months, with the median follow up period of 22.3 month. The median survival time was 30.2, 22.3 months for the experiment group and control group respectively, the Log-rank test for the median survival time of the two groups showed that the experiment group was higher than control group (HR = 1.87, 95%CI: 1.06-3.64, P< 0.05); the main adverse events of the two groups were grade 1 and 2 gastrointestional reactions. Conclusion FOLFOX4 chemotherapy regimen can improve the long term survival time for patients after radical resection for colorectal cancer, without in-creasing the side effects.
