CAJ | 학술논문

目的通过分析1例伴有重症感染及罕见t(10;11)(q22;q23)重排的自发缓解急性髓系白血病(AML)病例,提高对该类疾病的认识.方法结合文献对伴t(10;11)(q22;q23)重排的自发缓解AML临床及实验室特征进行总结分析.结果与大多数自发缓解的患者相似,该例AML患者发生了严重的肝脏和肺部感染.与其他报道的自发缓解患者不同的是,该患者伴有罕见的t(10;11)(q22;q23)重排,目前伴有这种染色体重排的病例文献报道仅6例.该患者在严重感染得到控制后,没有应用任何化疗的情况下获得了完全缓解,染色体复查未发现原有染色体易位.结论白血病自发缓解是一种少见现象,这一现象的具体机制尚不清楚,可能与感染刺激炎症因子产生有关,也可能与炎症激活了免疫系统有关,或者有基因学因素的参与.进一步积累病例,有助于提高对该病的认识.
목적 통과분석1례반유중증감염급한견t(10;11)(q22;q23)중배적자발완해급성수계백혈병(AML)병례,제고대해류질병적인식.방법 결합문헌대반t(10;11)(q22;q23)중배적자발완해AML림상급실험실특정진행총결분석.결과 여대다수자발완해적환자상사,해례AML환자발생료엄중적간장화폐부감염.여기타보도적자발완해환자불동적시,해환자반유한견적t(10;11)(q22;q23)중배,목전반유저충염색체중배적병예문헌보도부6례.해환자재엄중감염득도공제후,몰유응용임하화료적정황하획득료완전완해,염색체복사미발현원유염색체역위.결론 백혈병자발완해시일충소견현상,저일현상적구체궤제상불청초,가능여감염자격염증인자산생유관,야가능여염증격활료면역계통유관,혹자유기인학인소적삼여.진일보적루병례,유조우제고대해병적인식.
Objective To summarize a case of acute myeloid leukemia (AML) with severe infection and a rare translocation of t (10;11) (q22;q23) who got spontaneous remission.Methods The laboratorial examination results and clinical data in this case were summarized in couple with the light of published literatures.Results Like most of the spontaneous remission cases,severe infection happened to this case of AML patient,but the different point was that a rare translocation of t (10;11) (q22;q23) was disclosed in this patient.There were only 6 cases of this kind of translocation reported by the literatures up to now.This patient got spontaneous remission after the controlled infection without any chemotherapy.The rare translocation of t(10;11) (q22;q23) disappeared after he got remission.Conclusion Spontaneous remission of acute leukemia was a rare phenomenon,the underlying mechanism was unclear,maybe due to the inflammatory factors triggered by infection,or the activated immune system by the infection,or even the role of gene mutation factors.Accumulating data might shed insight into this rare kind of disease.