中华血液学杂志
中華血液學雜誌
중화혈액학잡지
Chinese Journal of Hematology
2015年
8期
682-685
,共4页
冯晓燕%邓书会%安刚%秦小琪%隋伟薇%邹德慧%邱录贵%徐燕
馮曉燕%鄧書會%安剛%秦小琪%隋偉薇%鄒德慧%邱錄貴%徐燕
풍효연%산서회%안강%진소기%수위미%추덕혜%구록귀%서연
多发性骨髓瘤%骨病%DKK1
多髮性骨髓瘤%骨病%DKK1
다발성골수류%골병%DKK1
Multiple myeloma%Myeloma bone disease%Dickkopfl
目的 探讨血清DKK1水平与多发性骨髓瘤(MM)患者病程及MM骨病的关系.方法 纳入2010-2014年诊治的145例MM患者及43名正常对照者,通过全身骨骼X线检查确定骨病情况,ELISA法检测血清dickkopf1 (DKK1)蛋白表达水平.结果 145例患者中初治者79例,缓解者19例,复发进展者47例.初治组DKK1水平为2 155(646～35 251)ng/L,明显高于正常对照组[1 487(646～2 577)ng/L,P=0.000]、缓解组[1 136(431～3 582)ng/L,P=0.001]及复发进展组[1 695(431～3 582)ng/L,P=0.037],差异均有统计学意义.复发进展组患者DKK1表达稍高于缓解患者,但差异无统计学意义(P=0.078).合并骨病者的血清DKK1水平[2 519(646～35 251)ng/L]显著高于无骨病者[1 910(660～26925)ng/L],差异有统计学意义(P=0.005),溶骨性病变部位0、1～3、＞3处患者血清DKK1水平分别为1 910(660～26 925)、2 155(1 369～5 974)、2 547(646～35 251)ng/L,差异有统计学意义(P=0.018).结论 MM患者血清DKK1表达水平不仅与MM疾病状态相关,且与溶骨性病变及其数目相关,为临床进行DKK1靶向治疗MM提供了理论依据.
目的 探討血清DKK1水平與多髮性骨髓瘤(MM)患者病程及MM骨病的關繫.方法 納入2010-2014年診治的145例MM患者及43名正常對照者,通過全身骨骼X線檢查確定骨病情況,ELISA法檢測血清dickkopf1 (DKK1)蛋白錶達水平.結果 145例患者中初治者79例,緩解者19例,複髮進展者47例.初治組DKK1水平為2 155(646～35 251)ng/L,明顯高于正常對照組[1 487(646～2 577)ng/L,P=0.000]、緩解組[1 136(431～3 582)ng/L,P=0.001]及複髮進展組[1 695(431～3 582)ng/L,P=0.037],差異均有統計學意義.複髮進展組患者DKK1錶達稍高于緩解患者,但差異無統計學意義(P=0.078).閤併骨病者的血清DKK1水平[2 519(646～35 251)ng/L]顯著高于無骨病者[1 910(660～26925)ng/L],差異有統計學意義(P=0.005),溶骨性病變部位0、1～3、＞3處患者血清DKK1水平分彆為1 910(660～26 925)、2 155(1 369～5 974)、2 547(646～35 251)ng/L,差異有統計學意義(P=0.018).結論 MM患者血清DKK1錶達水平不僅與MM疾病狀態相關,且與溶骨性病變及其數目相關,為臨床進行DKK1靶嚮治療MM提供瞭理論依據.
목적 탐토혈청DKK1수평여다발성골수류(MM)환자병정급MM골병적관계.방법 납입2010-2014년진치적145례MM환자급43명정상대조자,통과전신골격X선검사학정골병정황,ELISA법검측혈청dickkopf1 (DKK1)단백표체수평.결과 145례환자중초치자79례,완해자19례,복발진전자47례.초치조DKK1수평위2 155(646～35 251)ng/L,명현고우정상대조조[1 487(646～2 577)ng/L,P=0.000]、완해조[1 136(431～3 582)ng/L,P=0.001]급복발진전조[1 695(431～3 582)ng/L,P=0.037],차이균유통계학의의.복발진전조환자DKK1표체초고우완해환자,단차이무통계학의의(P=0.078).합병골병자적혈청DKK1수평[2 519(646～35 251)ng/L]현저고우무골병자[1 910(660～26925)ng/L],차이유통계학의의(P=0.005),용골성병변부위0、1～3、＞3처환자혈청DKK1수평분별위1 910(660～26 925)、2 155(1 369～5 974)、2 547(646～35 251)ng/L,차이유통계학의의(P=0.018).결론 MM환자혈청DKK1표체수평불부여MM질병상태상관,차여용골성병변급기수목상관,위림상진행DKK1파향치료MM제공료이론의거.
Objective To study the association between the level of serum DKK1 and disease course of multiple myeloma (MM) as well as myeloma bone disease.Methods This study enrolled 145 cases of MM (including 79 newly diagnosed MM,19 responded MM,47 relapsed or progressive MM) whose lytic bone disease were evaluated by conventional radiography,ELISA was used to detect the concentration of serum DKK1.Results Serum DKK-1 elevated in newly diagnosed MM compared with normal donors [2 155(646-35 251) vs 1 487(646-2 577) ng/L,P=0.000],those responded [1 136(431-3 582) ng/L,P=0.001] and relapsed/progressive MM [1 695 (431-3 582) ng/L,P=0.037],and the level of relapsed/progressive MM was marginally higher than the responded ones.Moreover,MM patients without lytic lesions in conventional radiography had significantly lower DKK-1 levels than those with lytic bone disease [1 910(660-26 925) vs 2 519(646-35 251) ng/L,P=0.005].Notably serum DKK-1 correlated with the number of bone lesions [0 vs 1-3 vs ＞3 lesions:1 910(660-26 925) vs 2 155(1 369-5 974) vs 2 547(646-35 251) ng/L,P=0.018].Conclusion DKK-1 serum concentration correlated with disease course of MM and myeloma bone disease,indicating that DKK-1 was an important factor for the extent of bone disease,which supporting the hypothesis of DKK-1 as a therapeutic target in myeloma bone disease.
