CAJ | 학술논문

目的：探讨T2DM合并高尿酸血症（HUA）与心血管疾病危险因素的关系。方法回顾性调查T2DM患者3174例，分析336例 T2DM 合并 HUA 患者与心血管危险因素的关系。结果T2DM患者3174例，其中，男2441例，女733例，年龄24～91岁，平均（60.23±9.77）岁；T2DM 合并HUA（HUA组）患者336例，HUA 患病率为10.6％。 HUA 组年龄≥60岁（65.2％ vs 48.1％）、女性（29.3％ vs 22.3％）、BMI≥25.0 kg／m2（74.4％ vs 59.9％）、TG≥1.70 mmol／L（59.8％ vs 42.4％）、TC≥5.7 mmol／L（37.8％ vs 29.1％）、HDL‐C＜1.04 mmol／L（13.7％ vs 8.8％）、血肌酐（Scr）≥110μmol／L （30.4％ vs 19.0％）、BUN≥7.0 mmol／L（41.1％ vs 26.2％）的患者比例高于单纯 T2DM 组（P＜0.05）。二分类非条件Logistic回归分析显示，高龄、女性、BMI≥25.0 kg／m2、高TG血症、高TC血症、低HDL‐C血症、Scr≥110μmol／L、BUN≥7.0 mmol／L是T2DM患者发生HUA的独立危险因素（P＜0.05）。结论 T2DM患者合并HUA与高龄、女性、肥胖、血脂异常及肾功能减退相关。
목적：탐토T2DM합병고뇨산혈증（HUA）여심혈관질병위험인소적관계。방법회고성조사T2DM환자3174례，분석336례 T2DM 합병 HUA 환자여심혈관위험인소적관계。결과T2DM환자3174례，기중，남2441례，녀733례，년령24～91세，평균（60.23±9.77）세；T2DM 합병HUA（HUA조）환자336례，HUA 환병솔위10.6％。 HUA 조년령≥60세（65.2％ vs 48.1％）、녀성（29.3％ vs 22.3％）、BMI≥25.0 kg／m2（74.4％ vs 59.9％）、TG≥1.70 mmol／L（59.8％ vs 42.4％）、TC≥5.7 mmol／L（37.8％ vs 29.1％）、HDL‐C＜1.04 mmol／L（13.7％ vs 8.8％）、혈기항（Scr）≥110μmol／L （30.4％ vs 19.0％）、BUN≥7.0 mmol／L（41.1％ vs 26.2％）적환자비례고우단순 T2DM 조（P＜0.05）。이분류비조건Logistic회귀분석현시，고령、녀성、BMI≥25.0 kg／m2、고TG혈증、고TC혈증、저HDL‐C혈증、Scr≥110μmol／L、BUN≥7.0 mmol／L시T2DM환자발생HUA적독립위험인소（P＜0.05）。결론 T2DM환자합병HUA여고령、녀성、비반、혈지이상급신공능감퇴상관。
Objective To explore the relationship of hyperuricemia (HUA) and cardiovascular risk factors in T2DM. Methods A total of 3174 subjects with T2DM were screened. The relationship between HUA and cardiovascular risk factors were evaluated in 336 subjects with HUA. Results A total of 3174 T2DM were enrolled in this study. Male and female were 2441 and 733 respectively. The average age was (60.23 ± 9.77) years ,from 24 to 91 years old. There were 336 patients with HUA. The prevalence rate of HUA was 10.6% in this cohort. The rate of age≥60 years (65.2% vs 48.1% ) ,female (29.3% vs 22.3% ) ,BMI≥25.0 kg/m2 (74.4% vs 59.9% ) ,TG≥1.70 mmol/L (59.8% vs 42.4% ) ,TC≥5.7 mmol/L (37.8% vs 29.1% ) ,HDL‐C < 1.04 mmol/L (13.7% vs 8.8% ) ,Scr ≥ 110 μmol/L (30.4% vs 19.0% ) ,BUN≥7.0 mmol/L (41.1% vs 26.2% ) in HUA patients were higher than in non‐HUA patients (P<0.05). Binary non‐conditional logistic regression analysis showed that ,advanced age , female ,BMI≥25.0 kg/m2 ,high TG ,high TC ,low HDL‐C ,Scr≥110 μmol/L ,BUN ≥7.0 mmol/L were independent risk factors for HUA in T2DM patients (P< 0.05). Conclusion Advanced age ,female , obesity ,dyslipidemia and renal impairment are associated with the occurrence of HUA in T2DM.