CAJ | 학술논문

聚腺苷二磷酸核糖聚合酶（PARP）可能是糖尿病周围神经病变（DPN）发病机制中的关键触发酶，通过氧化应激等途径导致DPN发生。PARP在DNA修复、基因表达、细胞周期和长期记忆等生物功能方面均发挥重要作用。一旦PARP过度激活，可诱导细胞死亡、抑制糖酵解、大量消耗ATP、促进炎性反应、增加氧氮自由基离子形成和介导氧化应激，引发DPN。本文就 PARP、氧化应激等因素在DPN中的作用作一阐述。
취선감이린산핵당취합매（PARP）가능시당뇨병주위신경병변（DPN）발병궤제중적관건촉발매，통과양화응격등도경도치DPN발생。PARP재DNA수복、기인표체、세포주기화장기기억등생물공능방면균발휘중요작용。일단PARP과도격활，가유도세포사망、억제당효해、대량소모ATP、촉진염성반응、증가양담자유기리자형성화개도양화응격，인발DPN。본문취 PARP、양화응격등인소재DPN중적작용작일천술。
[Summary] Poly adenosine diphosphate (ADP) ribose polymerase (PARP) may act as a key trigger enzyme in the pathogenesis of diabetic peripheral neuropathy (DPN). PARP may play an important role in the development of DPN through a variety of mechanisms linking with DNA repair ,gene expression ,cell cycle ,long‐term memory and other biological processes. The excessive activation of PARP can induce cell death ,inhibition of glycolysis ,consumption of ATP ,response to inflammation ,formation of oxygen ions and oxidative stress. This article reviewed the relationship of PARP and oxidative stress and DPN.