CAJ | 학술논문

Box-Behnken Design(BBD)效应面法是一种实验条件寻优的方法，采用多元二次回归方程拟合各因素与响应值之间的函数关系，找出预测的响应最优值以及相应的实验条件，是种多因素非线性实验优化方法，可以评估因素的非线性影响，在处方优化中广泛使用。该设计方法试验次数少，应用方便，优选的条件预测性好。目前，微球、自乳化释药体系、脂质体等制剂的处方优化越来越多选择BBD的优化法。
Box-Behnken Design(BBD)효응면법시일충실험조건심우적방법，채용다원이차회귀방정의합각인소여향응치지간적함수관계，조출예측적향응최우치이급상응적실험조건，시충다인소비선성실험우화방법，가이평고인소적비선성영향，재처방우화중엄범사용。해설계방법시험차수소，응용방편，우선적조건예측성호。목전，미구、자유화석약체계、지질체등제제적처방우화월래월다선택BBD적우화법。
Box-Behnken Design (BBD) response surface method is a method of optimal experimental conditions. It finds out the optimal prediction of response values and the corresponding experimental conditions between the multi-variate regression equation fitting each factor and response values. It is a kind of multi-factor non-linear optimization experiment method, can be used for assessed the non-linear effects of factors, and it is widely used in formulation opti-mization. This design has the advantages of fewer experiments, convenience and better prediction. At present, BBD can be used more and more frequently to optimize the formulation of microspheres, self-emulsifying drug release system, li-posome and so on.