中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2015年
7期
653-656
,共4页
糖尿病周围神经病变%氧化应激%炎症%血红素加氧酶-1
糖尿病週圍神經病變%氧化應激%炎癥%血紅素加氧酶-1
당뇨병주위신경병변%양화응격%염증%혈홍소가양매-1
Diabetic peripheral neuropathy (DPN )%Oxidative stress (OS )%Inflammation%Haem oxygenase-1(HO-1)
DPN的发生发展是复杂的、多种致病因素共同作用的结果，氧化应激（OS ）和炎症在其中发挥重要作用。血红素加氧酶‐1（HO‐1）及其降解产物具有抗氧化、抗炎、抗凋亡、促血管生成等多种功效，可作为DPN防治研究的新靶点。
DPN的髮生髮展是複雜的、多種緻病因素共同作用的結果，氧化應激（OS ）和炎癥在其中髮揮重要作用。血紅素加氧酶‐1（HO‐1）及其降解產物具有抗氧化、抗炎、抗凋亡、促血管生成等多種功效，可作為DPN防治研究的新靶點。
DPN적발생발전시복잡적、다충치병인소공동작용적결과，양화응격（OS ）화염증재기중발휘중요작용。혈홍소가양매‐1（HO‐1）급기강해산물구유항양화、항염、항조망、촉혈관생성등다충공효，가작위DPN방치연구적신파점。
[Summary] The pathogenesis of diabetic peripheral neuropathy (DPN ) is the result of complex multiple concurrent pathogenic factors ,among which oxidative stress and inflammation play important roles. Multiple data have indicated that haem oxygenase‐1 (HO‐1) and its degradation products products possess the functions of anti‐oxidation ,anti‐inflammation ,anti‐apoptosis and pro‐angiogenesis ,which now becomes a new target for the treatment of DPN. We will briefly review the progression on the research of HO‐1 and DPN.
