中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2015年
7期
583-586
,共4页
王晓强%王晓雷%张磊%刘玉%王娜%陈淑芳%陈洋%胡霞%吕洪财%董砚虎
王曉彊%王曉雷%張磊%劉玉%王娜%陳淑芳%陳洋%鬍霞%呂洪財%董硯虎
왕효강%왕효뢰%장뢰%류옥%왕나%진숙방%진양%호하%려홍재%동연호
糖代谢%胰升血糖素%胰岛素%相关性
糖代謝%胰升血糖素%胰島素%相關性
당대사%이승혈당소%이도소%상관성
Glycometabolism%Glucagon%Insulin%Correlation
目的：探讨胰岛素（Ins）、胰升血糖素（Glu）和 Ins／Glu比值与不同糖代谢状态的相关性。方法选取T2DM患者（T2DM组）81例、IGR患者（IGR组）35例及糖耐量正常（NGT组）者38名，均行75 g OGT T或标准馒头餐试验，分别测定各时点血糖、Ins和Glu水平。结果各组FIns水平比较，差异无统计学意义（P＞0.05）。T2DM组0.5 hIns、1 hIns水平低于NGT和IGR组，IGR组2 hIns水平高于NGT组（P＜0.01或 P＜0.05）。IGR组胰岛素曲线下面积（AUCi ）较 T2DM 组升高（P＜0.01）。除3 h外，T2DM组空腹及糖负荷后各时点Glu水平均高于NGT组和IGR组。T2DM组AUCglu较NGT组和IGR组增大（P＜0.05）。 T2DM 组空腹、0.5 h及1 hIns／Glu比值均低于 NGT 组和 IGR组（P＜0.05）。AUCglu与体重、WC、BMI、HbA1c、Scr及SUA水平呈正相关（P＜0.01）。结论 Glu分泌紊乱是T2DM患者胰岛功能受损的重要表现。应用 Ins／Glu比值能更好的反映胰岛α及β细胞功能异常情况。
目的：探討胰島素（Ins）、胰升血糖素（Glu）和 Ins／Glu比值與不同糖代謝狀態的相關性。方法選取T2DM患者（T2DM組）81例、IGR患者（IGR組）35例及糖耐量正常（NGT組）者38名，均行75 g OGT T或標準饅頭餐試驗，分彆測定各時點血糖、Ins和Glu水平。結果各組FIns水平比較，差異無統計學意義（P＞0.05）。T2DM組0.5 hIns、1 hIns水平低于NGT和IGR組，IGR組2 hIns水平高于NGT組（P＜0.01或 P＜0.05）。IGR組胰島素麯線下麵積（AUCi ）較 T2DM 組升高（P＜0.01）。除3 h外，T2DM組空腹及糖負荷後各時點Glu水平均高于NGT組和IGR組。T2DM組AUCglu較NGT組和IGR組增大（P＜0.05）。 T2DM 組空腹、0.5 h及1 hIns／Glu比值均低于 NGT 組和 IGR組（P＜0.05）。AUCglu與體重、WC、BMI、HbA1c、Scr及SUA水平呈正相關（P＜0.01）。結論 Glu分泌紊亂是T2DM患者胰島功能受損的重要錶現。應用 Ins／Glu比值能更好的反映胰島α及β細胞功能異常情況。
목적：탐토이도소（Ins）、이승혈당소（Glu）화 Ins／Glu비치여불동당대사상태적상관성。방법선취T2DM환자（T2DM조）81례、IGR환자（IGR조）35례급당내량정상（NGT조）자38명，균행75 g OGT T혹표준만두찬시험，분별측정각시점혈당、Ins화Glu수평。결과각조FIns수평비교，차이무통계학의의（P＞0.05）。T2DM조0.5 hIns、1 hIns수평저우NGT화IGR조，IGR조2 hIns수평고우NGT조（P＜0.01혹 P＜0.05）。IGR조이도소곡선하면적（AUCi ）교 T2DM 조승고（P＜0.01）。제3 h외，T2DM조공복급당부하후각시점Glu수평균고우NGT조화IGR조。T2DM조AUCglu교NGT조화IGR조증대（P＜0.05）。 T2DM 조공복、0.5 h급1 hIns／Glu비치균저우 NGT 조화 IGR조（P＜0.05）。AUCglu여체중、WC、BMI、HbA1c、Scr급SUA수평정정상관（P＜0.01）。결론 Glu분비문란시T2DM환자이도공능수손적중요표현。응용 Ins／Glu비치능경호적반영이도α급β세포공능이상정황。
Objective To investigate the relationship between serum insulin ,glucagon levels and insulin/glucagon ratios and different glucose intolerance status. Methods 81 patients with newly diagnosed type 2 diabetes (T2DM) ,35 with impaired glucose regulation (IGR) and 38 with normal glucose tolerance (NGT) were enrolled. All subjects received 75 g oral glucose tolerance test with measurement of plasma glucose ,insulin and glucagon at fasting and 0.5 h ,1 h ,2 h and 3 h. Results There was no difference on fasting insulin among NGT ,IGR and T2DM group. Compared with NGT or IGR ,T2DM had lower insulin levels at 0.5 h and 1 h after glucose load(P<0.01). IGR had higher insulin level at 2 h than NGT group(P<0.05). The area under the curve(AUC) of insulin was larger in IGR group than in DM group(P<0.01). T2DM patients had higher level of glucagon at fasting ,0.5 h ,1 h and 2 h compared with NGT or IGR.T2DM had the largest AUC of glucagon among three groups(P<0.05). The ratio of insulin to glucagon at fasting ,0.5 h and 1 h were lower in T2DM group than in NGT and IGR group.The AUC of glucagon was positively associated with body weight ,waist ,BMI ,HbA1c ,serum creatinine and uric acid (P<0.05). Conclusion Glucagon secretion is impaired in T2DM patients accompanying with beta cell dysfunction. The ratio of insulin to glucagon may be a better parameter reflecting the pancreatic alpha and beta cell dysfunction.
