CAJ | 학술논문

目的：研究抗骨质疏松（ OP）药物对腰椎间盘突出症（ LDH）是否有预防和治疗作用。方法选取2011年4月～2012年4月在我院诊断不合并腰椎间盘突出症的骨质疏松症50岁以上患者119例，根据不同治疗方案分为3个治疗组A、B、C及对照组A，合并腰椎间盘突出症的骨质疏松患者共76例，根据不同治疗方案分为3个治疗组D、E、F及对照组B。治疗组A、D予以钙剂、阿法骨化醇胶丸、阿仑膦酸钠片口服；治疗组B、E予以钙剂、阿法骨化醇胶丸口服、唑来膦酸注射液静脉滴注；治疗组C、F接受口服钙剂和阿法骨化醇胶丸。对照组A、B为不愿进行药物治疗的病例。观察应用抗骨质疏松药2年对腰椎间盘突出症防治的效果。结果予不同治疗方案后，治疗组A、治疗组B腰椎间盘突出症的发病率低于治疗组C及对照组A（ P＜0．05）。合并腰椎间盘突出症的骨质疏松治疗组D、E、F病例下腰痛评分升高、疼痛发作频率下降（P＜0．05）。治疗组D、治疗组E治疗后CT表现较治疗前基本无变化（P＞0．05）；治疗组F及对照组CT影像表现较观察起点有加重（P＜0．05），治疗组D与治疗组E之间、治疗组F与对照组B之间CT表现比较无统计学意义（ P＞0．05）。结论标准抗骨质疏松治疗方案能有效防治腰椎间盘突出症。
목적：연구항골질소송（ OP）약물대요추간반돌출증（ LDH）시부유예방화치료작용。방법선취2011년4월～2012년4월재아원진단불합병요추간반돌출증적골질소송증50세이상환자119례，근거불동치료방안분위3개치료조A、B、C급대조조A，합병요추간반돌출증적골질소송환자공76례，근거불동치료방안분위3개치료조D、E、F급대조조B。치료조A、D여이개제、아법골화순효환、아륜련산납편구복；치료조B、E여이개제、아법골화순효환구복、서래련산주사액정맥적주；치료조C、F접수구복개제화아법골화순효환。대조조A、B위불원진행약물치료적병례。관찰응용항골질소송약2년대요추간반돌출증방치적효과。결과여불동치료방안후，치료조A、치료조B요추간반돌출증적발병솔저우치료조C급대조조A（ P＜0．05）。합병요추간반돌출증적골질소송치료조D、E、F병례하요통평분승고、동통발작빈솔하강（P＜0．05）。치료조D、치료조E치료후CT표현교치료전기본무변화（P＞0．05）；치료조F급대조조CT영상표현교관찰기점유가중（P＜0．05），치료조D여치료조E지간、치료조F여대조조B지간CT표현비교무통계학의의（ P＞0．05）。결론표준항골질소송치료방안능유효방치요추간반돌출증。
Objective To study the effect of anti-osteoporosis medicine on the prevention and treatment of lumbar disc herniation ( LDH) in patients combined with osteoporosis ( OP) .Methods One hundred and nineteen patients with OP without LDH were randomly divided into 4 groups: the treatment group A, B, and C and the control group A.Seventy-six patients with OP were randomly divided into the treatment group D, E, and F and the control group B.The treatment group A and D were treated with calcium, oral alfacalcidol, and alendronate.The treatment group B and E were treated with calcium, alfacalcidol, and injection of zoledronic acid.The treatment group C and F were treated with calcium and alfacalcidol.The control group A and B were patients who did not will to accept treatment.The efficacy of the anti-OP medicines was observed in 2 years.Results The incidence of LDH in the treatment group A and B was significantly lower than that in the treatment group C and the control group A (P<0.05). After treatment, the lower back pain score in the treatment group D, E, and F increased significantly, and the attack frequency of LDH decreased significantly ( P<0.05 ) .In the CT scans of the treatment group D and E, there was no significant difference between pre-treatment and after treatment (P>0.05).The CT images of the treatment group F and the control B were more severe than those in the beginning of the study (P<0.05).And there was no significant difference between the treatment group D and E, and the treatment group F and the control B (P>0.05).Conclusion The standardized anti-osteoporosis treatment can effectively prevent and treat LDH combined with OP.