CAJ | 학술논문

目的：观察红细胞分布宽度(RDW)与频发室性期前收缩(FPVC)患者左心室肥厚(LVH)的相关性,探讨可能影响FPVC发生LVH的因素。方法连续入选2014年3月~2015年3月于首都医科大学宣武医院心脏科门诊122例明确诊断为FPVC患者,平均年龄(57.00±13.16)岁。所有患者均检测生化指标及血常规指标,行超声心动图检查并计算左室心肌质量指数(LVMI)。定义LVH为院女性患者LVMI≥110 g/m2,男性患者LVMI≥135 g/m2。根据LVMI将患者分为FPVC合并LVH组(观察组,n越66)与FPVC无LVH组(对照组,n越56)。应用多元线性回归及Logistic回归分析RDW与FPVC患者LVH的相关性。结果两组间性别、红细胞计数(RBC)、血红蛋白(Hb)、空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)以及合并疾病情况差异均无统计学意义(P跃0.05)；观察组年龄、室早负荷(PVC burden)及RDW水平均高于对照组,差异有统计学意义(P<0.05)。Pearson相关分析显示,RDW与LVMI呈正相关(r=0.259,P=0.004)。多元线性回归分析结果显示,年龄、RDW、室早负荷与LVMI呈线性正相关(P<0.05)。在校正了混杂因素后Logistic回归分析显示,RDW仍是PVC合并LVH的独立预测因素(OR =0.455,95%CI院0.224~0.922,P=0.029)。结论FPVC患者的RDW与LVMI呈正相关,RDW可能是FPVC患者发生LVH的预测因素。
목적：관찰홍세포분포관도(RDW)여빈발실성기전수축(FPVC)환자좌심실비후(LVH)적상관성,탐토가능영향FPVC발생LVH적인소。방법련속입선2014년3월~2015년3월우수도의과대학선무의원심장과문진122례명학진단위FPVC환자,평균년령(57.00±13.16)세。소유환자균검측생화지표급혈상규지표,행초성심동도검사병계산좌실심기질량지수(LVMI)。정의LVH위원녀성환자LVMI≥110 g/m2,남성환자LVMI≥135 g/m2。근거LVMI장환자분위FPVC합병LVH조(관찰조,n월66)여FPVC무LVH조(대조조,n월56)。응용다원선성회귀급Logistic회귀분석RDW여FPVC환자LVH적상관성。결과량조간성별、홍세포계수(RBC)、혈홍단백(Hb)、공복혈당(FBG)、총담고순(TC)、삼선감유(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)이급합병질병정황차이균무통계학의의(P약0.05)；관찰조년령、실조부하(PVC burden)급RDW수평균고우대조조,차이유통계학의의(P<0.05)。Pearson상관분석현시,RDW여LVMI정정상관(r=0.259,P=0.004)。다원선성회귀분석결과현시,년령、RDW、실조부하여LVMI정선성정상관(P<0.05)。재교정료혼잡인소후Logistic회귀분석현시,RDW잉시PVC합병LVH적독립예측인소(OR =0.455,95%CI원0.224~0.922,P=0.029)。결론FPVC환자적RDW여LVMI정정상관,RDW가능시FPVC환자발생LVH적예측인소。
Objective To investigate the relationship between the red blood cell distribution width (RDW) and left ven-tricular hypertrophy (LVH), study the predictors of LVH in patients with frequent premature ventricular contraction (FPVC). Methods 122 patients with FPVC from March 2014 to March 2015 were selected from Department of Cardiol-ogy, Xuanwu Hospital, Capital Medical University, average age of (57.00±13.16) years. The biochemical indexes, blood routine index and echocardiography were detected, the left ventricular myocardial mass index (LVMI) was calculated. Definition of left ventricular hypertrophy:women with LVMI≥110 g/m2 or men with LVMI≥135 g/m2. All patients were divided into 2 groups according to the LVMI:observation group (FPVC combined with LVH, n=66) and control group (only FPVC, n = 56). The correlation between RDW and LVH of patients with FPVC was analyzed by multivariate lin-ear regression and Logistic regression. Results There were no significant differences in sex, red blood cell count (RBC), hemoglobin (Hb), fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), high density lipoprotein choles-terol (HDL-C), low density lipoprotein cholesterol (LDL-C) and comorbidities between the two groups (P>0.05). The levels of age, RDW and PVC burden in observation group were significantly higher than those in control group (P<0.05). Pearson correlation analysis showed that RDW was significantly correlated with LV-MI (r = 0.259, P= 0.004). Multivariate linear regres-sion analysis showed, age, RDW, PVC burden and LVMI had linear positve correlation. After correction for confounding factors, Logistic regression showed that RDW was an in-dependent predictor of LVH in patients with FPVC (OR =0.455, 95%CI: 0.224-0.922, P= 0.029). Conclusion RDW and LVMI is positively correlated in patients with FPVC, and RDW is an independent predictor for FPVC with LVH.