化学与生物工程
化學與生物工程
화학여생물공정
CHEMISTRY & BIOENGINEERING
2015年
8期
23-27
,共5页
纳米脂质体%乳腺癌%核酸适配体%靶向载药体系
納米脂質體%乳腺癌%覈痠適配體%靶嚮載藥體繫
납미지질체%유선암%핵산괄배체%파향재약체계
liposome nanocarrier%breast cancer%aptamer%target drug delivery system
将核酸适配体修饰的 DSPE-PEG5000（DSPE-PEG5000-Aptamer）和 DSPE-PEG2000自组装构建纳米脂质体靶向载药体系，使核酸适配体充分暴露在载体表面，提高了癌细胞对药物的摄取能力，并考察了载药体系对乳腺癌细胞 MCF-7的靶向毒性。结果表明，构建的纳米脂质体靶向载药体系能选择性进入癌细胞，增强药物的抗癌能力。
將覈痠適配體脩飾的 DSPE-PEG5000（DSPE-PEG5000-Aptamer）和 DSPE-PEG2000自組裝構建納米脂質體靶嚮載藥體繫，使覈痠適配體充分暴露在載體錶麵，提高瞭癌細胞對藥物的攝取能力，併攷察瞭載藥體繫對乳腺癌細胞 MCF-7的靶嚮毒性。結果錶明，構建的納米脂質體靶嚮載藥體繫能選擇性進入癌細胞，增彊藥物的抗癌能力。
장핵산괄배체수식적 DSPE-PEG5000（DSPE-PEG5000-Aptamer）화 DSPE-PEG2000자조장구건납미지질체파향재약체계，사핵산괄배체충분폭로재재체표면，제고료암세포대약물적섭취능력，병고찰료재약체계대유선암세포 MCF-7적파향독성。결과표명，구건적납미지질체파향재약체계능선택성진입암세포，증강약물적항암능력。
Liposome nanocarrier target drug delivery system was constructed by self-assembly of DSPE-PEG5000-Aptamer and DSPE-PEG2000.And the aptamer was exposed on the surface of the carrier.Cellular up-take capacity of cancer cells was enhanced.Target toxicity against breast cancer cell MCF-7 was investigated. Results showed that liposome nanocarrier target drug delivery system could enhance the cancer cells specific in-ternalization and improved anti-cancer efficacy.
