心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
JOURNAL OF CARDIOVASCULAR REHABILITATION MEDICINE
2015年
4期
382-385
,共4页
冠心病%半胱氨酸蛋白酶抑制物C%冠状动脉旁路移植术,非体外循环
冠心病%半胱氨痠蛋白酶抑製物C%冠狀動脈徬路移植術,非體外循環
관심병%반광안산단백매억제물C%관상동맥방로이식술,비체외순배
Coronary disease%Cystatin C%Coronary artery bypass,off-pump
目的：观察接受不停跳冠脉旁路分流术（OPCABG）患者术后血清胱抑素 C（Cys C）水平，探讨其与冠状动脉病变的关系。方法：选择2013年8月～2013年11月在我院心外科行 OPCABG 患者321例，按照病变支数分为单支组（11例）、双支组（33例）和多支组（277例），采用双抗酶联免疫吸附法（ELISA）测定术后患者血清 Cys C 水平。结果：冠脉病变单支组、双支组和多支组 CysC 水平：OPCABG 术前依次为（0.732±0.286）mg／L、（0.807±0.265）mg／L、（0.911±0.273）mg／L，3组间有显著差异（F ＝3.942，P ＝0.038）；术后依次为（0.616±0.198）mg／L、（0.607±0.201）mg／L、（0.646±0.166）mg／L 3组间无显著差异（F ＝0.493，P ＝0.617），说明原先冠状动脉病变的程度与OPCABG 术后 CysC 水平无明显关系（P ＞0.05）。结论：不停跳冠状动脉搭桥术患者术后血清胱抑素 C 水平与原先冠状动脉病变程度无明显关系，即不停跳冠状动脉搭桥术对于冠心病患者是一有效治疗手段。
目的：觀察接受不停跳冠脈徬路分流術（OPCABG）患者術後血清胱抑素 C（Cys C）水平，探討其與冠狀動脈病變的關繫。方法：選擇2013年8月～2013年11月在我院心外科行 OPCABG 患者321例，按照病變支數分為單支組（11例）、雙支組（33例）和多支組（277例），採用雙抗酶聯免疫吸附法（ELISA）測定術後患者血清 Cys C 水平。結果：冠脈病變單支組、雙支組和多支組 CysC 水平：OPCABG 術前依次為（0.732±0.286）mg／L、（0.807±0.265）mg／L、（0.911±0.273）mg／L，3組間有顯著差異（F ＝3.942，P ＝0.038）；術後依次為（0.616±0.198）mg／L、（0.607±0.201）mg／L、（0.646±0.166）mg／L 3組間無顯著差異（F ＝0.493，P ＝0.617），說明原先冠狀動脈病變的程度與OPCABG 術後 CysC 水平無明顯關繫（P ＞0.05）。結論：不停跳冠狀動脈搭橋術患者術後血清胱抑素 C 水平與原先冠狀動脈病變程度無明顯關繫，即不停跳冠狀動脈搭橋術對于冠心病患者是一有效治療手段。
목적：관찰접수불정도관맥방로분류술（OPCABG）환자술후혈청광억소 C（Cys C）수평，탐토기여관상동맥병변적관계。방법：선택2013년8월～2013년11월재아원심외과행 OPCABG 환자321례，안조병변지수분위단지조（11례）、쌍지조（33례）화다지조（277례），채용쌍항매련면역흡부법（ELISA）측정술후환자혈청 Cys C 수평。결과：관맥병변단지조、쌍지조화다지조 CysC 수평：OPCABG 술전의차위（0.732±0.286）mg／L、（0.807±0.265）mg／L、（0.911±0.273）mg／L，3조간유현저차이（F ＝3.942，P ＝0.038）；술후의차위（0.616±0.198）mg／L、（0.607±0.201）mg／L、（0.646±0.166）mg／L 3조간무현저차이（F ＝0.493，P ＝0.617），설명원선관상동맥병변적정도여OPCABG 술후 CysC 수평무명현관계（P ＞0.05）。결론：불정도관상동맥탑교술환자술후혈청광억소 C 수평여원선관상동맥병변정도무명현관계，즉불정도관상동맥탑교술대우관심병환자시일유효치료수단。
Objective:To observe serum cystatin C (Cys C)level in patients before and after off-pump coronary ar-tery bypass grafting (OPCABG),and explore its relationship with coronary artery lesion.Methods:A total of 321 patients,who received OPCABG in department of heart surgery of our hospital from Aug 2013 to Nov 2013,were selected.According to number of diseased coronary vessels,they were divided into single-vessel group (n= 11), double-vessel group (n=33)and multi-vessel group (n=277).Double antibody enzyme linked immunosorbent assay (ELISA)was used to measure serum Cys C level in all groups.Results:The Cys C levels in single-vessel group, double-vessel group,multi-vessel group before OPCABG were (0.732 ± 0.286)mg/L, (0.807 ± 0.265)mg/L, (0.911±0.273)mg/L respectively,there were significant difference (F=3.942,P =0.038);and after OPCABG were (0.616±0.198)mg/L,(0.607±0.201)mg/L, (0.646±0.166)mg/L respectively ,there were no signifi-cant difference (F=0.493,P =0.617),namely there was no significant relationship between coronary artery disease extent and Cys C level after OPCABG,P >0.05. Conclusion:There is no significant relationship between original coronary artery disease extent and serum cystatin C level after off-pump coronary artery bypass grafting,namely off-pump coronary artery bypass grafting is an effective therapeutic measure for patients with coronary heart disease.
