CAJ | 학술논문

目的：分析心力衰竭患者血浆细胞因子变化与心功能的关系。方法：选择2011年8月至2013年8月我院收治的58例心力衰竭患者为心衰组，另选同期来我院进行体检的58名健康人群作为健康对照组，运用酶联免疫吸附试验（ELISA）检测其 C 反应蛋白（CRP）、白介素-6（IL-6）、肿瘤坏死因子－α（TNF-α）、Th1／Th2细胞因子干扰素-γ（IFN-γ）、白介素-4（IL-4）水平，并进行比较。结果：与健康对照组比较，心衰组 NYHAⅡ级、NYHAⅢ级、Ⅳ级患者的 CRP [（3.57±1.15）mg／L 比（6.21±1.89）mg／L、（6.89±2.02）mg／L、（7.57±2.11）mg／L]、TNF-α[（4.31±2.09）ng／L 比（13.97±3.24）ng／L、（16.23±3.59）ng／L、（18.55±3.61）ng／L]、IL-6[（8.25±1.2）ng／L 比（19.27±4.26）ng／L、（25.78±4.89）ng／L、（34.44±6.12）ng／L]水平均明显升高；外周血IFN-γ水平[（48.21±7.52）pg／ml 比（68.63±8.24）pg／ml、（73.91±10.14）pg／ml、（82.44±11.58）pg／ml]、IFN-γ／ IL-4[（1.07±0.12）比（1.73±1.26）、（2.09±1.31）、（2.38±1.40）]均显著升高（P 均＜0.05）；NY-HAⅢ级、Ⅳ级患者的外周血 IL-4[（45.11±6.97）pgl／ml 比（35.31±5.47）pgl／ml、（34.56±4.92）pgl／ml]水平显著降低（P 均＜0.05）。NYHAⅢ级、Ⅳ级患者的外周血 IFN-γ、IFN-γ／IL-4显著高于 NYHAⅡ级组患者，且NYHAⅣ级组患者又显著高于Ⅲ级组的（P 均＜0.05）。结论：心力衰竭患者血浆细胞因子与心功能密切相关。
목적：분석심력쇠갈환자혈장세포인자변화여심공능적관계。방법：선택2011년8월지2013년8월아원수치적58례심력쇠갈환자위심쇠조，령선동기래아원진행체검적58명건강인군작위건강대조조，운용매련면역흡부시험（ELISA）검측기 C 반응단백（CRP）、백개소-6（IL-6）、종류배사인자－α（TNF-α）、Th1／Th2세포인자간우소-γ（IFN-γ）、백개소-4（IL-4）수평，병진행비교。결과：여건강대조조비교，심쇠조 NYHAⅡ급、NYHAⅢ급、Ⅳ급환자적 CRP [（3.57±1.15）mg／L 비（6.21±1.89）mg／L、（6.89±2.02）mg／L、（7.57±2.11）mg／L]、TNF-α[（4.31±2.09）ng／L 비（13.97±3.24）ng／L、（16.23±3.59）ng／L、（18.55±3.61）ng／L]、IL-6[（8.25±1.2）ng／L 비（19.27±4.26）ng／L、（25.78±4.89）ng／L、（34.44±6.12）ng／L]수평균명현승고；외주혈IFN-γ수평[（48.21±7.52）pg／ml 비（68.63±8.24）pg／ml、（73.91±10.14）pg／ml、（82.44±11.58）pg／ml]、IFN-γ／ IL-4[（1.07±0.12）비（1.73±1.26）、（2.09±1.31）、（2.38±1.40）]균현저승고（P 균＜0.05）；NY-HAⅢ급、Ⅳ급환자적외주혈 IL-4[（45.11±6.97）pgl／ml 비（35.31±5.47）pgl／ml、（34.56±4.92）pgl／ml]수평현저강저（P 균＜0.05）。NYHAⅢ급、Ⅳ급환자적외주혈 IFN-γ、IFN-γ／IL-4현저고우 NYHAⅡ급조환자，차NYHAⅣ급조환자우현저고우Ⅲ급조적（P 균＜0.05）。결론：심력쇠갈환자혈장세포인자여심공능밀절상관。
Objective:To analyze the relationship between plasma cytokine changes and cardiac function in patients with heart failure.Methods:A total of 58 patients with heart failure treated in our hospital from Aug 2011 to Aug 2013 were selected as heart failure group,another 58 healthy people undergoing physical examination in our hospital during the same period were regarded as healthy control group.Enzyme linked immunosorbent assay (ELISA)was used to measure levels of C reactive protein (CRP),interleukin- 6 (IL-6),tumor necrosis factor-α (TNF-α), Th1/Th2 cytokine interferon-γ(IFN-γ)and interleukin-4 (IL-4),and the results were compared between two groups.Results:Compared with healthy control group,there were significant rise in levels of CRP [(3.57±1.15) mg/L vs.(6.21 ± 1.89)mg/L,(6.89 ± 2.02)mg/L,(7.57 ± 2.11)mg/L],TNF-α [(4.31 ± 2.09)ng/L vs. (13.97±3.24)ng/L,(16.23±3.59)ng/L,(18.55±3.61)ng/L]and IL-6 [(8.25±1.2)ng/L vs.(19.27±4.26) ng/L,(25.78±4.89)ng/L,(34.44± 6.12)ng/L];and significant increase in peripheral blood levels of IFN-γ[(48.21±7.52)pg/ml vs.(68.63±8.24)pg/ml,(73.91±10.14)pg/ml,(82.44±11.58)pg/ml]and IFN-γ/IL-4 [(1.07±0.12)vs.(1.73±1.26),(2.09± 1.31),(2.38± 1.40)]in patients with NYHA class Ⅱ,Ⅲ and Ⅳfrom heart failure group (P <0.05 all);and significant reduction in peripheral level of IL-4 [(45.11±6.97)pgl/ml vs.(35.31±5.47)pgl/ml,(34.56±4.92)pgl/ml]in patients with NYHA class Ⅲ and Ⅳ,P <0.05 both.The IFN-γand IFN-γ/IL-4 levels in patients with NYHA class Ⅲ and Ⅳ were significant higher than those of NYHA class Ⅱ,and those of NYHA class Ⅳ group were significant higher than those of NYHA class Ⅲ group,P <0.05 all.Conclusion:Plasma cytokine levels are closely related to cardiac function in patients with heart failure.