中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
22期
136-138,144
,共4页
蛛网膜下隙出血%脑血管痉挛%盐酸法舒地尔%尼莫地平
蛛網膜下隙齣血%腦血管痙攣%鹽痠法舒地爾%尼莫地平
주망막하극출혈%뇌혈관경련%염산법서지이%니막지평
Subarachnoid hemorrhage%Cerebral vasospasm%Fasudil hydrochloride%Nimodipine
目的：探讨盐酸法舒地尔治疗蛛网膜下隙出血(SAH)后并发迟发脑血管痉挛的临床效果。方法选取2010年6月~2012年5月在本院神经内科住院的52例SAH患者作为研究对象，按照住院就诊先后顺序随机分成对照组(27例)和治疗组(25例)。两组均进行常规治疗，治疗组加用法舒地尔治疗，对照组加用尼莫地平治疗，疗程均为2周。观察两组的总有效率及脑血管痉挛情况。结果治疗组的总有效率为88.0%，明显高于对照组的70.4%(P<0.05)；治疗后，两组的脑血管痉挛指数均较治疗前显著降低(P<0.05)，且治疗组脑血管痉挛指数低于对照组(P<0.05)。结论盐酸法舒地尔治疗SAH后并发迟发脑血管痉挛的效果显著，是一种较尼莫地平同样安全但疗效更好的药物。
目的：探討鹽痠法舒地爾治療蛛網膜下隙齣血(SAH)後併髮遲髮腦血管痙攣的臨床效果。方法選取2010年6月~2012年5月在本院神經內科住院的52例SAH患者作為研究對象，按照住院就診先後順序隨機分成對照組(27例)和治療組(25例)。兩組均進行常規治療，治療組加用法舒地爾治療，對照組加用尼莫地平治療，療程均為2週。觀察兩組的總有效率及腦血管痙攣情況。結果治療組的總有效率為88.0%，明顯高于對照組的70.4%(P<0.05)；治療後，兩組的腦血管痙攣指數均較治療前顯著降低(P<0.05)，且治療組腦血管痙攣指數低于對照組(P<0.05)。結論鹽痠法舒地爾治療SAH後併髮遲髮腦血管痙攣的效果顯著，是一種較尼莫地平同樣安全但療效更好的藥物。
목적：탐토염산법서지이치료주망막하극출혈(SAH)후병발지발뇌혈관경련적림상효과。방법선취2010년6월~2012년5월재본원신경내과주원적52례SAH환자작위연구대상，안조주원취진선후순서수궤분성대조조(27례)화치료조(25례)。량조균진행상규치료，치료조가용법서지이치료，대조조가용니막지평치료，료정균위2주。관찰량조적총유효솔급뇌혈관경련정황。결과치료조적총유효솔위88.0%，명현고우대조조적70.4%(P<0.05)；치료후，량조적뇌혈관경련지수균교치료전현저강저(P<0.05)，차치료조뇌혈관경련지수저우대조조(P<0.05)。결론염산법서지이치료SAH후병발지발뇌혈관경련적효과현저，시일충교니막지평동양안전단료효경호적약물。
Objective To explore the clinical effect of fasudil hydrochloride in the treatment of delayed cerebral va-sospasm after subarachnoid hemorrhage (SAH). Methods 52 patients with SAH from June 2010 to May 2012 in depart-ment of neurology of our hospital were selected as research object,and they were randomly divided into the control group (27 cases) and treatment group (25 cases) according to the order of visiting the hospital.The treatment group was treated with fasudil hydrochloride,the control group was treated with nimodipine on the basis of the conventional thera-py respectively.The treatment course was 2 weeks.The total effective rate and the condition of cerebral vasospasm in two groups was observed. Results The total effective rate of the treatment group was 88.0%,which was significantly higher than 70.4% of the control group (P<0.05).After treatment,The index number of cerebral vasospasm in two groups was significantly lower than that before treatment (P<0.05),and the index number of cerebral vasospasm in treatment group was lower than that of control group (P<0.05). Conclusion The effect of asudil hydrochloride in the treatment of delayed cerebral vasospasm after SAH is significant,and which is a relatively safe drug and even much better in cura-tive effect compared with nimodipine.
