CAJ | 학술논문

目的：探讨儿童喘息性疾病的药物联合治疗效果。方法选择2012年1月~2013年12月在本院住院治疗并符合本研究纳入标准的152例喘息性疾病患儿作为研究对象，将其按照随机数字表法分为A组(n=52)、B组(n=49)及C组(n=51)。 A组行雾化吸入高渗盐水联合布地奈德、小剂量肝素治疗；B组行雾化吸入高渗盐水联合布地奈德治疗；C组行单纯雾化吸入高渗盐水治疗。记录3组患儿的临床症状消失时间、住院时间以及治疗有效率。结果 A、B组临床症状消失时间和住院时间均显著短于C组(P<0.05)，且A组哮鸣音消失时间显著短于B组(P<0.05)，但A、B两组的气促、湿啰音消失时间和住院时间差异无统计学意义(P跃0.05)。 A、B组的治疗总有效率均显著高于C组(P<0.05)，且A组高于B组，但差异无统计学意义(P跃0.05)。结论雾化吸入高渗盐水联合布地奈德、小剂量肝素治疗儿童喘息性疾病安全有效。
목적：탐토인동천식성질병적약물연합치료효과。방법선택2012년1월~2013년12월재본원주원치료병부합본연구납입표준적152례천식성질병환인작위연구대상，장기안조수궤수자표법분위A조(n=52)、B조(n=49)급C조(n=51)。 A조행무화흡입고삼염수연합포지내덕、소제량간소치료；B조행무화흡입고삼염수연합포지내덕치료；C조행단순무화흡입고삼염수치료。기록3조환인적림상증상소실시간、주원시간이급치료유효솔。결과 A、B조림상증상소실시간화주원시간균현저단우C조(P<0.05)，차A조효명음소실시간현저단우B조(P<0.05)，단A、B량조적기촉、습라음소실시간화주원시간차이무통계학의의(P약0.05)。 A、B조적치료총유효솔균현저고우C조(P<0.05)，차A조고우B조，단차이무통계학의의(P약0.05)。결론무화흡입고삼염수연합포지내덕、소제량간소치료인동천식성질병안전유효。
Objective To investigate the effect of drug combination therapy for children with asthmatic disease. Meth-ods 152 cases of children with asthmatic diseases hospitalized in our hospital and met the inclusion criteria from Jan-uary 2012 to December 2013 were selected as research object.They were divided into group A(n=52),group B(n=49) and group C (n=51) according to random number table method.Group A was treated with hypertonic saline,budesonide and low-dose heparin,group B was treated with hypertonic saline and budesonide,group C was treated with hypertonic saline.The clinical symptoms disappear time,hospital stays and effective rate was retrospectively analyzed. Results The clinical symptoms disappear time,hospital stays in group A and B was significantly shorter than those in group C (P<0.05).The time of anhelation and moist rales disappear in group A was shorter than that in group B,but there was no statistically significant difference (P>0.05).The effective rate in group A and B was significantly higher than that in group C (P<0.05).In addition,the effective rate in group A was higher than that in group B,but there was no statistically significant difference(P>0.05). Conclusion It was effective and safety for the treatment of children asthmatic disease by using the application of atomization inhalation hypertonic saline,budesonide and low-dose heparin.