中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
22期
112-114
,共3页
阿卡波糖%二甲双胍%胰岛素类似物%肥胖2型糖尿病%短期效果
阿卡波糖%二甲雙胍%胰島素類似物%肥胖2型糖尿病%短期效果
아잡파당%이갑쌍고%이도소유사물%비반2형당뇨병%단기효과
Acarbose%Metformin%Insulin analogue%Obesity type 2 diabetes%Short-term effect
目的：探讨阿卡波糖、二甲双胍联合胰岛素类似物治疗肥胖2型糖尿病的短期效果。方法选取2013年6月~2014年3月在本院就诊的65例肥胖2型糖尿病患者，将其随机分为观察组(n=33)和对照组(n=32)。对照组在常规处理基础上给予甘精胰岛素与赖脯胰岛素，观察组在对照组基础上给予二甲双胍缓释片与阿卡波糖治疗。测定两组治疗前后空腹血糖(FPG)、空腹血胰岛素(FINS)、餐后2 h血糖(2 h PG)、胰岛素抵抗指数(IR)、胰岛素抵抗指数(IR)等指标，并观察两组的临床疗效、餐时胰岛素停用率、低血糖发生率。结果观察组的临床疗效总有效率为90.91%，显著高于对照组的81.25%，两组差异有统计学意义(P<0.05)。两组治疗前后FPG、2 h PG、FINS、IR、IS等比较，差异有统计学意义(P<0.05)，且治疗后观察组的FINS、IR指标显著低于对照组(P<0.05)，但两组治疗后的FPG、2 h PG、IS各指标差异无统计学意义(P跃0.05)。观察组的餐时胰岛素停用率为75.26%，显著高于对照组的59.38(P<0.05)。观察组的低血糖发生率为12.12%，显著低于对照组的25.00%(P<0.05)。结论对肥胖2型糖尿病患者采用阿卡波糖、二甲双胍联合胰岛素类似物治疗，临床疗效显著，值得推广应用。
目的：探討阿卡波糖、二甲雙胍聯閤胰島素類似物治療肥胖2型糖尿病的短期效果。方法選取2013年6月~2014年3月在本院就診的65例肥胖2型糖尿病患者，將其隨機分為觀察組(n=33)和對照組(n=32)。對照組在常規處理基礎上給予甘精胰島素與賴脯胰島素，觀察組在對照組基礎上給予二甲雙胍緩釋片與阿卡波糖治療。測定兩組治療前後空腹血糖(FPG)、空腹血胰島素(FINS)、餐後2 h血糖(2 h PG)、胰島素牴抗指數(IR)、胰島素牴抗指數(IR)等指標，併觀察兩組的臨床療效、餐時胰島素停用率、低血糖髮生率。結果觀察組的臨床療效總有效率為90.91%，顯著高于對照組的81.25%，兩組差異有統計學意義(P<0.05)。兩組治療前後FPG、2 h PG、FINS、IR、IS等比較，差異有統計學意義(P<0.05)，且治療後觀察組的FINS、IR指標顯著低于對照組(P<0.05)，但兩組治療後的FPG、2 h PG、IS各指標差異無統計學意義(P躍0.05)。觀察組的餐時胰島素停用率為75.26%，顯著高于對照組的59.38(P<0.05)。觀察組的低血糖髮生率為12.12%，顯著低于對照組的25.00%(P<0.05)。結論對肥胖2型糖尿病患者採用阿卡波糖、二甲雙胍聯閤胰島素類似物治療，臨床療效顯著，值得推廣應用。
목적：탐토아잡파당、이갑쌍고연합이도소유사물치료비반2형당뇨병적단기효과。방법선취2013년6월~2014년3월재본원취진적65례비반2형당뇨병환자，장기수궤분위관찰조(n=33)화대조조(n=32)。대조조재상규처리기출상급여감정이도소여뢰포이도소，관찰조재대조조기출상급여이갑쌍고완석편여아잡파당치료。측정량조치료전후공복혈당(FPG)、공복혈이도소(FINS)、찬후2 h혈당(2 h PG)、이도소저항지수(IR)、이도소저항지수(IR)등지표，병관찰량조적림상료효、찬시이도소정용솔、저혈당발생솔。결과관찰조적림상료효총유효솔위90.91%，현저고우대조조적81.25%，량조차이유통계학의의(P<0.05)。량조치료전후FPG、2 h PG、FINS、IR、IS등비교，차이유통계학의의(P<0.05)，차치료후관찰조적FINS、IR지표현저저우대조조(P<0.05)，단량조치료후적FPG、2 h PG、IS각지표차이무통계학의의(P약0.05)。관찰조적찬시이도소정용솔위75.26%，현저고우대조조적59.38(P<0.05)。관찰조적저혈당발생솔위12.12%，현저저우대조조적25.00%(P<0.05)。결론대비반2형당뇨병환자채용아잡파당、이갑쌍고연합이도소유사물치료，림상료효현저，치득추엄응용。
Objective To explore the short-term effect of acarbose and metformin combined with insulin analogues in the treatment of obese type 2 diabetes. Methods 65 patients with obese type 2 diabetes in our hospital from March 2013 to June 2014 were collected,and they were randomly divided into the observation group (n=33)and control group (n=32).The control group was given insulin glargine and insulin lispro on the basis of the conventional treatment.The observation group was given metformin and acarbose on the basis of the control group. Determination of The index of fasting plasma glucose(FPG),fasting blood insulin(FINS),2 h postprandial blood glucose (2 h PG),insulin resistance(IR) and insulin resistance index(IR) in two groups was measured before and after the treatment,and clinical curative effects, postprandial insulin withdrawal rate and incidence of hypoglycemia in two groups was observed. Results The total ef-fective rate in observation group was 90.91%,and significantly higher than that of the control group(81.25%).The differ-ence between the two groups had statistical significance (P<0.05).Before and after the treatment,the difference of FPG,2 h PG,FINS,IR and IS of two groups was significantly(P<0.05),and index of FINS,IR in observation group after treatment was significantly lower than that of control group (P<0.05),but there was no statistically significant difference in the in-dex of FPG,2 h PG、IS in two groups after treatment(P>0.05).The postprandial insulin discontinuation rate of observation group was 75.26%,significantly higher than that of the control group(59.38%)(P<0.05).The incidence of hypoglycemia in the observation group was 25.00%,which was significantly lower than that of the control group (12.12%)(P<0.05). Con-clusion The clinical curative effect of acarbose,metformin combined with insulin analogues in the treatment of obese type 2 diabetic patients is significant.It is worthy of application and application.
