心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
JOURNAL OF CARDIOVASCULAR REHABILITATION MEDICINE
2015年
4期
353-355,356
,共4页
杨禹娟%李喆%张炜%邢坤%田刚
楊禹娟%李喆%張煒%邢坤%田剛
양우연%리철%장위%형곤%전강
老年人%高同种半胱氨酸血症%急性冠状动脉综合征
老年人%高同種半胱氨痠血癥%急性冠狀動脈綜閤徵
노년인%고동충반광안산혈증%급성관상동맥종합정
Aged%Hyperhomocysteinemia%Acute coronary syndrome
目的:探讨老年急性冠脉综合征(ACS)伴高同型半胱氨酸血症(HHCY)患者血清基质金属蛋白酶(MMP-2)水平与冠脉病变严重程度的相关性。方法:收集老年 ACS 患者105例,依据血清同型半胱氨酸(Hcy)水平分为 ACS 伴 HHCY 组(56例)与单纯 ACS 组(49例),选择65例健康体检者作为健康对照组。以 Gensini积分表示冠状动脉病变严重程度;采用酶联免疫吸附试验法检测各组血清 MMP-2水平。结果:与健康对照组比较,HHCY 伴 ACS 组和单纯 ACS 组 MMP-2水平均显著升高[(140.8±50.1)ng/ml 比(442.5±98.2)ng/ml、(297.9±86.3)ng/ml,P 均<0.01]。ACS 伴 HHCY 组 Gensini 积分明显高于单纯 ACS 组[(1.9±0.2)分比(1.1±0.3)分,P <0.01]。Pearson 相关分析显示,ACS 伴 HHCY 组 Gensini 积分与 MMP-2水平呈正相关(r =0.424,P <0.05)。结论:在老年人群中,急性冠脉综合征伴高同型半胱氨酸血症患者的血清基质金属蛋白酶2水平与冠脉病变严重程度呈显著正相关。
目的:探討老年急性冠脈綜閤徵(ACS)伴高同型半胱氨痠血癥(HHCY)患者血清基質金屬蛋白酶(MMP-2)水平與冠脈病變嚴重程度的相關性。方法:收集老年 ACS 患者105例,依據血清同型半胱氨痠(Hcy)水平分為 ACS 伴 HHCY 組(56例)與單純 ACS 組(49例),選擇65例健康體檢者作為健康對照組。以 Gensini積分錶示冠狀動脈病變嚴重程度;採用酶聯免疫吸附試驗法檢測各組血清 MMP-2水平。結果:與健康對照組比較,HHCY 伴 ACS 組和單純 ACS 組 MMP-2水平均顯著升高[(140.8±50.1)ng/ml 比(442.5±98.2)ng/ml、(297.9±86.3)ng/ml,P 均<0.01]。ACS 伴 HHCY 組 Gensini 積分明顯高于單純 ACS 組[(1.9±0.2)分比(1.1±0.3)分,P <0.01]。Pearson 相關分析顯示,ACS 伴 HHCY 組 Gensini 積分與 MMP-2水平呈正相關(r =0.424,P <0.05)。結論:在老年人群中,急性冠脈綜閤徵伴高同型半胱氨痠血癥患者的血清基質金屬蛋白酶2水平與冠脈病變嚴重程度呈顯著正相關。
목적:탐토노년급성관맥종합정(ACS)반고동형반광안산혈증(HHCY)환자혈청기질금속단백매(MMP-2)수평여관맥병변엄중정도적상관성。방법:수집노년 ACS 환자105례,의거혈청동형반광안산(Hcy)수평분위 ACS 반 HHCY 조(56례)여단순 ACS 조(49례),선택65례건강체검자작위건강대조조。이 Gensini적분표시관상동맥병변엄중정도;채용매련면역흡부시험법검측각조혈청 MMP-2수평。결과:여건강대조조비교,HHCY 반 ACS 조화단순 ACS 조 MMP-2수평균현저승고[(140.8±50.1)ng/ml 비(442.5±98.2)ng/ml、(297.9±86.3)ng/ml,P 균<0.01]。ACS 반 HHCY 조 Gensini 적분명현고우단순 ACS 조[(1.9±0.2)분비(1.1±0.3)분,P <0.01]。Pearson 상관분석현시,ACS 반 HHCY 조 Gensini 적분여 MMP-2수평정정상관(r =0.424,P <0.05)。결론:재노년인군중,급성관맥종합정반고동형반광안산혈증환자적혈청기질금속단백매2수평여관맥병변엄중정도정현저정상관。
Objective:To explore the correlation between serum level of matrix metalloproteinase 2 (MMP-2)and se-verity of coronary artery disease in aged patients with acute coronary syndrome (ACS)complicated hyperhomocys-teinemia (HHCY).Methods:According to serum level of homocysteine (Hcy),a total of 105 aged ACS patients were selected and divided into ACS+HHCY group (n=56)and pure ACS patients (n=49),another 65 healthy in-dividuals were enrolled as healthy control group.The severity of coronary artery disease was showed by Gensini score ;enzyme linked immunosorbent assay was used to measure serum MMP-2 level in each group.Results:Com-pared with healthy control group,there were significant rise in MMP-2 level [(140.8±50.1)ng/ml vs.(442.5± 98.2)ng/ml,(297.9±86.3)ng/ml]in ACS+HHCY group and pure ACS group,P <0.01. Gensini score in ACS+HHCY group was significantly higher than that of pure ACS group [(1.9±0.2)scores vs.(1.1±0.3)scores,P<0.01].Pearson correlation analysis indicated that Gensini score was positively correlated with MMP-2 level in ACS+HHCY group (r =0.424,P <0.05).Conclusion:The serum MMP-2 level is significantly positively correla-ted with severity of coronary artery disease in aged patients with ACS complicated HHCY.