CAJ | 학술논문

目的：探讨老年急性冠脉综合征（ACS）伴高同型半胱氨酸血症（HHCY）患者血清基质金属蛋白酶（MMP-2）水平与冠脉病变严重程度的相关性。方法：收集老年 ACS 患者105例，依据血清同型半胱氨酸（Hcy）水平分为 ACS 伴 HHCY 组（56例）与单纯 ACS 组（49例），选择65例健康体检者作为健康对照组。以 Gensini积分表示冠状动脉病变严重程度；采用酶联免疫吸附试验法检测各组血清 MMP-2水平。结果：与健康对照组比较，HHCY 伴 ACS 组和单纯 ACS 组 MMP-2水平均显著升高[（140.8±50.1）ng／ml 比（442.5±98.2）ng／ml、（297.9±86.3）ng／ml，P 均＜0.01]。ACS 伴 HHCY 组 Gensini 积分明显高于单纯 ACS 组[（1.9±0.2）分比（1.1±0.3）分，P ＜0.01]。Pearson 相关分析显示，ACS 伴 HHCY 组 Gensini 积分与 MMP-2水平呈正相关（r ＝0.424，P ＜0.05）。结论：在老年人群中，急性冠脉综合征伴高同型半胱氨酸血症患者的血清基质金属蛋白酶2水平与冠脉病变严重程度呈显著正相关。
목적：탐토노년급성관맥종합정（ACS）반고동형반광안산혈증（HHCY）환자혈청기질금속단백매（MMP-2）수평여관맥병변엄중정도적상관성。방법：수집노년 ACS 환자105례，의거혈청동형반광안산（Hcy）수평분위 ACS 반 HHCY 조（56례）여단순 ACS 조（49례），선택65례건강체검자작위건강대조조。이 Gensini적분표시관상동맥병변엄중정도；채용매련면역흡부시험법검측각조혈청 MMP-2수평。결과：여건강대조조비교，HHCY 반 ACS 조화단순 ACS 조 MMP-2수평균현저승고[（140.8±50.1）ng／ml 비（442.5±98.2）ng／ml、（297.9±86.3）ng／ml，P 균＜0.01]。ACS 반 HHCY 조 Gensini 적분명현고우단순 ACS 조[（1.9±0.2）분비（1.1±0.3）분，P ＜0.01]。Pearson 상관분석현시，ACS 반 HHCY 조 Gensini 적분여 MMP-2수평정정상관（r ＝0.424，P ＜0.05）。결론：재노년인군중，급성관맥종합정반고동형반광안산혈증환자적혈청기질금속단백매2수평여관맥병변엄중정도정현저정상관。
Objective:To explore the correlation between serum level of matrix metalloproteinase 2 (MMP-2)and se-verity of coronary artery disease in aged patients with acute coronary syndrome (ACS)complicated hyperhomocys-teinemia (HHCY).Methods:According to serum level of homocysteine (Hcy),a total of 105 aged ACS patients were selected and divided into ACS+HHCY group (n=56)and pure ACS patients (n=49),another 65 healthy in-dividuals were enrolled as healthy control group.The severity of coronary artery disease was showed by Gensini score ;enzyme linked immunosorbent assay was used to measure serum MMP-2 level in each group.Results:Com-pared with healthy control group,there were significant rise in MMP-2 level [(140.8±50.1)ng/ml vs.(442.5± 98.2)ng/ml,(297.9±86.3)ng/ml]in ACS+HHCY group and pure ACS group,P <0.01. Gensini score in ACS+HHCY group was significantly higher than that of pure ACS group [(1.9±0.2)scores vs.(1.1±0.3)scores,P<0.01].Pearson correlation analysis indicated that Gensini score was positively correlated with MMP-2 level in ACS+HHCY group (r =0.424,P <0.05).Conclusion:The serum MMP-2 level is significantly positively correla-ted with severity of coronary artery disease in aged patients with ACS complicated HHCY.