心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
JOURNAL OF CARDIOVASCULAR REHABILITATION MEDICINE
2015年
4期
369-372
,共4页
老年人%高同种半胱氨酸血症%心绞痛,不稳定型
老年人%高同種半胱氨痠血癥%心絞痛,不穩定型
노년인%고동충반광안산혈증%심교통,불은정형
Aged%Hyperhomocysteinemia%Angina,unstable
目的:探讨高同型半胱氨酸(Hcy)与高龄高血压及不稳定型心绞痛(UAP)的关系。方法:选择于我院心内科诊治的208例高龄高血压伴有心绞痛患者,分为 H 型高血压组(102例)和一般高血压组(106例),各组又分为 UAP 和稳定型心绞痛(SAP)两亚组,检测患者 Hcy、血糖、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)水平;通过 Gensini 评分系统对患者冠状动脉病变程度进行评分。结果:与一般高血压组比较,H 型高血压组 UAP 发病率(25.47%比46.08%)、Gensini 评分[(30.2±15.6)分比(46.1±18.7)分]显著升高(P <0.05);H 型高血压组中,UAP 组 Hcy 水平明显高于 SAP 组[(22.8±7.2)μmol/L 比(13.1±2.7)μmol/L],且 UAP 组高水平 Hcy 患者比例显著高于 SAP 组的(P 均<0.05);一般高血压组患者中,与 SAP 组比较,UAP 组 Hcy [(7.1±1.5)μmol/L 比(9.2±2.8)μmol/L]水平显著升高(P <0.05);Logisitic 回归分析表明对于高龄 UAP 患者,Hcy 是 UAP 的独立性危险因素(OR=1.9,95%CI:1.1~3.0,P =0.03)。结论:高龄H 型高血压患者的 UAP 发病率显著高于一般高血压患者,Hcy 是 UAP 的独立危险因素。
目的:探討高同型半胱氨痠(Hcy)與高齡高血壓及不穩定型心絞痛(UAP)的關繫。方法:選擇于我院心內科診治的208例高齡高血壓伴有心絞痛患者,分為 H 型高血壓組(102例)和一般高血壓組(106例),各組又分為 UAP 和穩定型心絞痛(SAP)兩亞組,檢測患者 Hcy、血糖、總膽固醇(TC)、高密度脂蛋白膽固醇(HDL-C)、甘油三酯(TG)水平;通過 Gensini 評分繫統對患者冠狀動脈病變程度進行評分。結果:與一般高血壓組比較,H 型高血壓組 UAP 髮病率(25.47%比46.08%)、Gensini 評分[(30.2±15.6)分比(46.1±18.7)分]顯著升高(P <0.05);H 型高血壓組中,UAP 組 Hcy 水平明顯高于 SAP 組[(22.8±7.2)μmol/L 比(13.1±2.7)μmol/L],且 UAP 組高水平 Hcy 患者比例顯著高于 SAP 組的(P 均<0.05);一般高血壓組患者中,與 SAP 組比較,UAP 組 Hcy [(7.1±1.5)μmol/L 比(9.2±2.8)μmol/L]水平顯著升高(P <0.05);Logisitic 迴歸分析錶明對于高齡 UAP 患者,Hcy 是 UAP 的獨立性危險因素(OR=1.9,95%CI:1.1~3.0,P =0.03)。結論:高齡H 型高血壓患者的 UAP 髮病率顯著高于一般高血壓患者,Hcy 是 UAP 的獨立危險因素。
목적:탐토고동형반광안산(Hcy)여고령고혈압급불은정형심교통(UAP)적관계。방법:선택우아원심내과진치적208례고령고혈압반유심교통환자,분위 H 형고혈압조(102례)화일반고혈압조(106례),각조우분위 UAP 화은정형심교통(SAP)량아조,검측환자 Hcy、혈당、총담고순(TC)、고밀도지단백담고순(HDL-C)、감유삼지(TG)수평;통과 Gensini 평분계통대환자관상동맥병변정도진행평분。결과:여일반고혈압조비교,H 형고혈압조 UAP 발병솔(25.47%비46.08%)、Gensini 평분[(30.2±15.6)분비(46.1±18.7)분]현저승고(P <0.05);H 형고혈압조중,UAP 조 Hcy 수평명현고우 SAP 조[(22.8±7.2)μmol/L 비(13.1±2.7)μmol/L],차 UAP 조고수평 Hcy 환자비례현저고우 SAP 조적(P 균<0.05);일반고혈압조환자중,여 SAP 조비교,UAP 조 Hcy [(7.1±1.5)μmol/L 비(9.2±2.8)μmol/L]수평현저승고(P <0.05);Logisitic 회귀분석표명대우고령 UAP 환자,Hcy 시 UAP 적독립성위험인소(OR=1.9,95%CI:1.1~3.0,P =0.03)。결론:고령H 형고혈압환자적 UAP 발병솔현저고우일반고혈압환자,Hcy 시 UAP 적독립위험인소。
Objective: To explore the relationship among advancod aged hypertension,unstable angina pectoris (UAP)and high homocysteine (Hcy)level.Methods:A total of 208 advanced aged patients with hypertension and angina pectoris,who were diagnosed and treated in our department of cardiology,were divided into H-type hyper-tension group (n=102)and general hypertension group (n=106).Each group was further divided into UAP sub-group and stable angina pectoris (SAP)subgroup.Levels of Hcy,blood glucose,total cholesterol (TC),high densi-ty lipoprotein cholesterol (HDL-C)and triglyceride (TG)were measured;Gensini scoring system was used to score extent of coronary artery lesion in these patients.Results:Compared with general hypertension group,there were significant rise in incidence rate of UAP (25.47% vs.46.08%)and Gensini score [(30.2±15.6)scores vs.(46.1 ±18.7)scores]in H-type hypertension group,P <0.05;in H-type hypertension group,Hcy level in UAP subgroup was significantly higher than that of SAP subgroup [(22.8±7.2)μmol/L vs.(13.1±2.7)μmol/L],and percent-age of paitents with high Hcy level in UAP group was significantly higher than that of SAP group,P <0.05 all;in general hypertension group,compared with SAP group,there were significant rise in levels of Hcy [(7.1 ± 1.5)μmol/L vs.(9.2±2.8)μmol/L]in UAP group,P <0.05 ;Logistic regression analysis indicated that for advanced aged UAP patients,Hcy is an independent risk factor of UAP (OR=1.9,95%CI:1.1~3.0,P =0.03).Conclu-sion:UAP incidence rate of H-type hypertension patients significantly rises than that of general hypertension pa-tients,Hcy is an independent risk factor of UAP.