中国骨质疏松杂志
中國骨質疏鬆雜誌
중국골질소송잡지
CHINESE JOURNAL OF OSTEOPOROSIS
2015年
7期
855-857,865
,共4页
糖尿病肾病%N端骨钙素%I型胶原氨基端延长肽%β-胶原降解产物
糖尿病腎病%N耑骨鈣素%I型膠原氨基耑延長肽%β-膠原降解產物
당뇨병신병%N단골개소%I형효원안기단연장태%β-효원강해산물
Diabetic nephropathy%N-bone-gamma-carboxyglutamic-acid-containing proteins%Total N-terminal propeptide of type I collagen%β-C-terminal telopeptides of type I collagen
目的:观察2型糖尿病肾病不同分期血清N端骨钙素( N-MID)、I型胶原氨基端延长肽( PINP)、β-胶原降解产物(β-CTX)水平的变化。方法收集2型糖尿病患者108例,根据尿微量白蛋白/肌酐比值及血清肌酐水平分为无微量蛋白尿组,微量白蛋白尿组,临床蛋白尿组,肾功能不全代偿组和肾功能不全失代偿组。记录其年龄、性别、病程、身高、体重、腰围、体重指数( BMI),测定血清N-MID、PINP、β-CTX水平。结果糖尿病肾病组的年龄、性别构成、腰围、臀围及BMI与无糖尿病肾病组比较,差别无统计学意义(P>0.05),而病程在各组间差别有统计学意义(P<0.05),其中微量白蛋白尿组病程最短为(8.3±3.5)年,肾功能不全失代偿组最长为(18.9±7.4)年。糖尿病肾病组的血清N-MID和PINP水平降低(P<0.05),随着糖尿病肾病分期的进展,血清N-MID和PINP水平有逐渐降低的趋势,但差别无统计学意义( P>0.05)。糖尿病肾病组的血清β-CTX较无糖尿病肾病组增高,差别有统计学意义(P<0.05),肾功能不全失代偿期时进一步明显增高,为(519.49±89.65)pg/ml。结论糖尿病肾病可引起骨的吸收增加,形成减少,通过监测骨代谢指标,有助于糖尿病肾病患者骨质疏松的早期诊断和干预,减少发生骨质疏松骨折的风险。
目的:觀察2型糖尿病腎病不同分期血清N耑骨鈣素( N-MID)、I型膠原氨基耑延長肽( PINP)、β-膠原降解產物(β-CTX)水平的變化。方法收集2型糖尿病患者108例,根據尿微量白蛋白/肌酐比值及血清肌酐水平分為無微量蛋白尿組,微量白蛋白尿組,臨床蛋白尿組,腎功能不全代償組和腎功能不全失代償組。記錄其年齡、性彆、病程、身高、體重、腰圍、體重指數( BMI),測定血清N-MID、PINP、β-CTX水平。結果糖尿病腎病組的年齡、性彆構成、腰圍、臀圍及BMI與無糖尿病腎病組比較,差彆無統計學意義(P>0.05),而病程在各組間差彆有統計學意義(P<0.05),其中微量白蛋白尿組病程最短為(8.3±3.5)年,腎功能不全失代償組最長為(18.9±7.4)年。糖尿病腎病組的血清N-MID和PINP水平降低(P<0.05),隨著糖尿病腎病分期的進展,血清N-MID和PINP水平有逐漸降低的趨勢,但差彆無統計學意義( P>0.05)。糖尿病腎病組的血清β-CTX較無糖尿病腎病組增高,差彆有統計學意義(P<0.05),腎功能不全失代償期時進一步明顯增高,為(519.49±89.65)pg/ml。結論糖尿病腎病可引起骨的吸收增加,形成減少,通過鑑測骨代謝指標,有助于糖尿病腎病患者骨質疏鬆的早期診斷和榦預,減少髮生骨質疏鬆骨摺的風險。
목적:관찰2형당뇨병신병불동분기혈청N단골개소( N-MID)、I형효원안기단연장태( PINP)、β-효원강해산물(β-CTX)수평적변화。방법수집2형당뇨병환자108례,근거뇨미량백단백/기항비치급혈청기항수평분위무미량단백뇨조,미량백단백뇨조,림상단백뇨조,신공능불전대상조화신공능불전실대상조。기록기년령、성별、병정、신고、체중、요위、체중지수( BMI),측정혈청N-MID、PINP、β-CTX수평。결과당뇨병신병조적년령、성별구성、요위、둔위급BMI여무당뇨병신병조비교,차별무통계학의의(P>0.05),이병정재각조간차별유통계학의의(P<0.05),기중미량백단백뇨조병정최단위(8.3±3.5)년,신공능불전실대상조최장위(18.9±7.4)년。당뇨병신병조적혈청N-MID화PINP수평강저(P<0.05),수착당뇨병신병분기적진전,혈청N-MID화PINP수평유축점강저적추세,단차별무통계학의의( P>0.05)。당뇨병신병조적혈청β-CTX교무당뇨병신병조증고,차별유통계학의의(P<0.05),신공능불전실대상기시진일보명현증고,위(519.49±89.65)pg/ml。결론당뇨병신병가인기골적흡수증가,형성감소,통과감측골대사지표,유조우당뇨병신병환자골질소송적조기진단화간예,감소발생골질소송골절적풍험。
Objective To investigate the levels of N-bone-gamma-carboxyglutamic-acid-containing proteins (N-MID), total N-terminal propeptide of type I collagen ( PINP) , andβ-C-terminal telopeptides of type I collagen (β-CTX) in patients with different stage of diabetic nephropathy.Methods A total of 108 patients with type 2 diabetes were collected.They were divided into no proteinuria group, trace proteinuria group, proteinuria group, compensatory renal insufficiency group, and incomplete compensation of renal function group, according to urinary albumin creatinine ratio and levels of serum creatinine.Their age, sex, duration of diabetes, height, weight, waistline, hipline, and BMI were recorded.The levels of N-MID, PINP, andβ-CTX in their serum were detected.Results The age, sex, waistline, hipline, and BMI showed no significant difference between patients with and without diabetic nephropathy ( P>0.05 ) .The duration of diabetes was different among the groups ( P<0.05 ) , which was the shortest (8.3 ±3.5 years) in trace proteinuria group and the longest (18.9 ±7.4 years) in incomplete compensation of renal function group.The levels of N-MID and PINP decreased in patients with diabetic nephropathy.With the development of the disease, they decreased continuously, but with no statistical significance ( P>0.05) .The serum level ofβ-CTX in diabetic nephropathy patients was higher than that in non nephropathy patients (P<0.05).It increased further in the stage of incomplete compensation of renal function.Conclusion Diabetic nephropathy causes increase of bone resorption and decrease of bone formation.Monitoring of bone metabolic markers may contribute to the early diagnose and treatment of osteoporosis in diabetic nephropathy patients, and may decrease the risk of osteoporotic fractures.