CAJ | 학술논문

目的：探讨老年2型糖尿病患者中性粒细胞／淋巴细胞比率（ NLR）水平与骨质疏松症的关系。方法收集203例老年2型糖尿病患者，其中骨质疏松症80例，记录患者一般资料，包括性别、年龄，体重指数，检测空腹血糖（ FBG）、总胆固醇（ TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）等生化指标及超敏C反应蛋白（hs－CRP），测定全血细胞计数（ CBC），进行白细胞分类计数，采用双能X线骨密度测量腰椎、股骨颈骨密度（ BMD），分析NLR水平与骨质疏松症的关系。结果骨质疏松症组年龄、性别、TG、BMD与无骨质疏松组比较有显著差异，及NLR水平明显高于无骨质疏松症组（ P＜0．05）。骨密度（ BMD）与炎症标记物（ NLR，hs－CRP）的相关性分析发现，腰椎、股骨颈BMD值和NLR有显著相关性（分别r＝0．348， P＜0．001；r＝0．264，P＝0．04），Logistic回归分析结果显示，在老年2型糖尿病患者中，高龄、女性、NLR和总甘油三酯水平是骨质疏松症的危险因素。结论老年2型糖尿病骨质疏松症患者NLR水平升高，与骨密度相关，表明炎症可能在骨重建中发挥着重要的作用。
목적：탐토노년2형당뇨병환자중성립세포／림파세포비솔（ NLR）수평여골질소송증적관계。방법수집203례노년2형당뇨병환자，기중골질소송증80례，기록환자일반자료，포괄성별、년령，체중지수，검측공복혈당（ FBG）、총담고순（ TC）、감유삼지（TG）、저밀도지단백（LDL）、고밀도지단백（HDL）등생화지표급초민C반응단백（hs－CRP），측정전혈세포계수（ CBC），진행백세포분류계수，채용쌍능X선골밀도측량요추、고골경골밀도（ BMD），분석NLR수평여골질소송증적관계。결과골질소송증조년령、성별、TG、BMD여무골질소송조비교유현저차이，급NLR수평명현고우무골질소송증조（ P＜0．05）。골밀도（ BMD）여염증표기물（ NLR，hs－CRP）적상관성분석발현，요추、고골경BMD치화NLR유현저상관성（분별r＝0．348， P＜0．001；r＝0．264，P＝0．04），Logistic회귀분석결과현시，재노년2형당뇨병환자중，고령、녀성、NLR화총감유삼지수평시골질소송증적위험인소。결론노년2형당뇨병골질소송증환자NLR수평승고，여골밀도상관，표명염증가능재골중건중발휘착중요적작용。
Objective To investigate the relationship between blood neutrophil lymphocyte ratio ( NLR ) and osteoporosis in elderly patients with type 2 diabetes mellitus ( T2DM).Methods Two hundred and three T2DM elderly patients including 80 osteoporosis patients were collected.The clinical data of patients including sex, age, and body mass index ( BMI) were recorded. Biochemical parameters including fasting blood glucose, total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein ( HDL) , whole blood cell count and leukocyte classification, and high sensitivity C reactive protein ( hs-CRP) were detected.Bone mineral density ( BMD) of the lumbar vertebrae and the femoral neck was measured.The relationship between NLR and osteoporosis statistical methods was analyzed.Results Sex ratio, age, TG, and BMD were different between the two groups, and the NLR level was higher in the osteoporosis group (P<0.05).There were significant correlation between the BMD of the lumbar vertebrae and the femoral neck and NLR (r=-0.348, P<0.001;r=-0.264, P=0.04).Logistic regression analysis showed that age, female gender, and TG level were risk factors for osteoporosis.Conclusion NLR level increases in the elderly type 2 diabetes mellitus patients with osteoporosis and it is correlated with BMD, suggesting that inflammation may play an important role in bone remodeling.