CAJ | 학술논문

目的：观察机体白三烯水平与成人支气管哮喘慢性持续期肺功能指标第1秒用力呼气容积(forced expiratory volume in one second，FEV1)/用力肺活量(forced vital capacity，FVC)比值及FEV1值的相关性，探讨白三烯水平对慢性持续期哮喘患者肺功能的影响。方法：募集成人慢性持续期哮喘患者96例，所有患者均按常规吸入福莫特罗/布地奈德进行基础治疗。治疗前及治疗后8周用ELISA检测尿白三烯E4(leukotriene E4，LTE4)浓度，用肺功能仪检测患者FVC值及FEV1值。同时募集健康对照者40例，检测尿LTE4水平。比较健康对照者与不同病情严重程度哮喘患者尿LTE4水平的差异，以及FEV1/FVC及FEV1值与尿LTE4水平的相关关系。结果：1)轻度持续、中度持续及重度持续期哮喘患者尿LTE4浓度均高于健康对照组(P<0.05)，且随着病情严重度增加尿LTE4浓度也升高。2)初始治疗前中度持续期患者FEV1/FVC及FEV1值与尿LTE4浓度均呈负相关(P<0.05)。结论：中度持续的哮喘患者肺功能与体内白三烯水平关系更为密切，中、重度持续的哮喘患者初始治疗时加用白三烯受体拮抗剂可能会更快改善肺功能。
목적：관찰궤체백삼희수평여성인지기관효천만성지속기폐공능지표제1초용력호기용적(forced expiratory volume in one second，FEV1)/용력폐활량(forced vital capacity，FVC)비치급FEV1치적상관성，탐토백삼희수평대만성지속기효천환자폐공능적영향。방법：모집성인만성지속기효천환자96례，소유환자균안상규흡입복막특라/포지내덕진행기출치료。치료전급치료후8주용ELISA검측뇨백삼희E4(leukotriene E4，LTE4)농도，용폐공능의검측환자FVC치급FEV1치。동시모집건강대조자40례，검측뇨LTE4수평。비교건강대조자여불동병정엄중정도효천환자뇨LTE4수평적차이，이급FEV1/FVC급FEV1치여뇨LTE4수평적상관관계。결과：1)경도지속、중도지속급중도지속기효천환자뇨LTE4농도균고우건강대조조(P<0.05)，차수착병정엄중도증가뇨LTE4농도야승고。2)초시치료전중도지속기환자FEV1/FVC급FEV1치여뇨LTE4농도균정부상관(P<0.05)。결론：중도지속적효천환자폐공능여체내백삼희수평관계경위밀절，중、중도지속적효천환자초시치료시가용백삼희수체길항제가능회경쾌개선폐공능。
Objective: To investigate the effect of leukotriene levels on the pulmonary function of patients with chronic persistent asthma, and to observe the correlation between concentration of leukotriene E4 (LTE4) in urine and the patients forced expiratory volume in the ifrst second (FEV1)/forced vital capacity (FVC) and FEV1 value. Methods: Ninety-six patients of asthma were studied and classified into three groups based on the severity of expiratory airlfow limitation: 1) mild persistent asthmatic group (FEV1 >80% predicted) included 40 patients; 2) moderate persistent asthmatic group (FEV1 of 60% to 80% predicted) included 48 patients; and 3) severe persistent asthmatic group (FEV1 <60% predicted) included 8 patients. All patients were used budesonide and <br> formoterol fumarate powder for inhalation. Before treatment and atfer treatment for 8 weeks, the concentration of urinary LTE4 were detected by ELISA, FEV1/FVC and FEV1 measured by pulmonary function instrument. At the same time, 40 cases of healthy controls were collected to detect the urinary LTE4.Results: 1) urinary LTE4 concentrations in mild, moderate and severe persistent patients were higher than those in healthy control group (P<0.05), and with the severity of the disease, the urinary LTE4 concentration was increased; 2) FEV1/FVC and FEV1 values were negatively correlated (P<0.05) in patients with moderate persistent asthma before budesonide and formoterol fumarate powder for inhalation treatment.Conclusion:The correlation between pulmonary function and leukotriene levels in moderate persistent asthmatic patients was more closely, moderate persistent and severe persistent asthmatic patients would beneift from administrated leukotriene receptor antagonist agents.