CAJ | 학술논문

目的：制备甘草酸脂质体，评价其在小鼠肝脏中的靶向性。方法以薄膜分散-超声法制备甘草酸脂质体，于小鼠尾静脉给药，RP-HPLC法测定肝脏和血液中不同时间的药物浓度。以甘草酸注射剂为对照，通过相对摄取率（re）、靶向效率（te）和峰浓度比（Ce）3个参数来评价脂质体的肝靶向效率。结果甘草酸脂质体肝脏相对摄取率re ＝1.4；甘草酸脂质体肝靶向效率te ＝0.092；甘草酸注射液te ＝0.059，肝脏中Ce ＝1.59，血液中Ce ＝0.99。结论与甘草酸注射剂相比，甘草酸脂质体有明显的肝靶向性。
목적：제비감초산지질체，평개기재소서간장중적파향성。방법이박막분산-초성법제비감초산지질체，우소서미정맥급약，RP-HPLC법측정간장화혈액중불동시간적약물농도。이감초산주사제위대조，통과상대섭취솔（re）、파향효솔（te）화봉농도비（Ce）3개삼수래평개지질체적간파향효솔。결과감초산지질체간장상대섭취솔re ＝1.4；감초산지질체간파향효솔te ＝0.092；감초산주사액te ＝0.059，간장중Ce ＝1.59，혈액중Ce ＝0.99。결론여감초산주사제상비，감초산지질체유명현적간파향성。
Objective To prepare liposomes of glycyrrhizic acid, and evaluate its liver targeting property in mice. Methods The liposomes were prepared with conventional rotary-evaporated film-ultrasonication method.The liposomes were injected into the mouse tail vein, and the concentration of glycyrrhizic acid was detected by RP-HPLC.The glycyrrhiz-ic acid injection was taken as control.The targeted indicators, including the relative tissue exposure ( re ) , targeting effi-ciency (te), and index of peak concentration ratio (Ce), were used to evaluate the liver targeting property.Results The re was 1.4, Te of the liposomes was 0.092, and te of the injection was 0.059.The Ce of the liver was 1.59, and the Ce of the blood was 0.99.Conclusion Compared with glycyrrhizic acid injection, the glycyrrhizic acid liposomes show good liv-er-targeting property.