CAJ | 학술논문

目的：探讨盐酸替罗非班对急性心肌梗死患者冠状动脉介入治疗的效果。方法选取本院2013年10月~2014年12月收治的120例急性心肌梗死患者作为研究对象，随机分为对照组、实验1组及实验2组，各40例，分别给予不同的治疗方法。比较3组PCI术中的梗死相关侵犯血管血流复流情况、心肌标志物检测情况以及主要心脏不良事件(MACE)发生情况。结果实验2组的TIMI3、TMPG3所占比例显著高于对照组和实验1组，差异有统计学意义(P<0.05)。实验2组的血小板活化度和MACE发生率显著低于对照组和实验1组，差异有统计学意义(P<0.05)。结论盐酸替罗非班在冠心病介入治疗中能够起到积极的治疗效果，并且临床效果与给药量有关，高剂量应用不但没有起到治疗作用，反而增加出血风险，甚至血小板激活。因此，盐酸替罗非班适时适量的使用能够提高临床治疗效果，值得临床推广应用。
목적：탐토염산체라비반대급성심기경사환자관상동맥개입치료적효과。방법선취본원2013년10월~2014년12월수치적120례급성심기경사환자작위연구대상，수궤분위대조조、실험1조급실험2조，각40례，분별급여불동적치료방법。비교3조PCI술중적경사상관침범혈관혈류복류정황、심기표지물검측정황이급주요심장불량사건(MACE)발생정황。결과실험2조적TIMI3、TMPG3소점비례현저고우대조조화실험1조，차이유통계학의의(P<0.05)。실험2조적혈소판활화도화MACE발생솔현저저우대조조화실험1조，차이유통계학의의(P<0.05)。결론염산체라비반재관심병개입치료중능구기도적겁적치료효과，병차림상효과여급약량유관，고제량응용불단몰유기도치료작용，반이증가출혈풍험，심지혈소판격활。인차，염산체라비반괄시괄량적사용능구제고림상치료효과，치득림상추엄응용。
Objective To explore the effect of tirofiban hydrochloride on percutaneous coronary intervention in patients with acute myocardial infarction (AMI). Methods 120 AMI patients from October 2013 to December 2014 in our hos-pital were selected and randomly divided into the control group,the experimental group one and the experimental group two.Different treatment methods was given reapectively.The clinical manifestations of re-flow of vascular blood flow be-ing invaded by infarction during PCI,detection of myocardial marker and occurrence of major adverse cardiovascular events (MACE) among three groups was compared. Results The proportion of TMPG3 and TIMI3 in the experimental group was higher than that in the control group and the experimental group one,with significant difference (P<0.05).The activity of blood platelets and the incidence rate of MACE in the experimental group two was lower than that in the control group and the experimental group one,with significant difference (P<0.05). Conclusion Tirofiban hydrochloride exerts a positive therapeutic effect in PCI,and its effect is related with the dosage.High-dose of tirofiban hydrochloride not only doesn’t take effect,but increases the risk of hemorrhage,even platelet activation.Therefore,appropriate dose of tirofiban hydrochloride can improve the clinical therapeutic effect,it is worthy of clinical promotion and application.