CAJ | 학술논문

目的： HGF及其受体c-met是很多系统中间充质-上皮互相作用的主要的介导者，毛囊周期性生长是典型的间充质-上皮互作模型，为证实HGF／c-met信号在小鼠毛囊周期生长过程中是否发挥作用。方法本实验运用免疫组织化学的方法对HGF／c-met在ICR小鼠毛囊生长期、退化期和休止期进行组织定位。结果 HGF主要位于真毛乳头和皮脂腺，c-met主要位于毛基质、根鞘部和表皮。 HGF及其受体在小鼠毛囊生长期表达量达到最高值，在退化期基本不表达，在休止期-生长期过渡时HGF及其受体表达量均上升。结论 HGF／c-met信号在ICR小鼠毛囊生长过程中起调控作用。
목적： HGF급기수체c-met시흔다계통중간충질-상피호상작용적주요적개도자，모낭주기성생장시전형적간충질-상피호작모형，위증실HGF／c-met신호재소서모낭주기생장과정중시부발휘작용。방법본실험운용면역조직화학적방법대HGF／c-met재ICR소서모낭생장기、퇴화기화휴지기진행조직정위。결과 HGF주요위우진모유두화피지선，c-met주요위우모기질、근초부화표피。 HGF급기수체재소서모낭생장기표체량체도최고치，재퇴화기기본불표체，재휴지기-생장기과도시HGF급기수체표체량균상승。결론 HGF／c-met신호재ICR소서모낭생장과정중기조공작용。
Objective HGF and its receptor ( c-met) are principal mediators of mesenchymal-epithelial interac-tion in several different systems.Moreover, hair follicle is a model of mesenchymal-epithelial interaction.The aim of this study was to explore whether HGF/c-met signal plays a role in the control of hair follicle growth cycle.Methods To ex-amine the localization of HGF/c-met in anagen, catagen and telogen in the hair follicle of ICR mice.Results HGF was mainly located in the dermal papilla and sebaceous gland, and c-Met in the hair matrix, root sheath and epidermis.Both HGF and c-met expressions peaked during anagen, not found in catagen, and increased during telogen-anagen phase.Con-clusions Our results demonstrate a regulatory role of HGF and c-met in the control of hair follicle growth in ICR mice.