中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
22期
36-38
,共3页
慢性心力衰竭%同型半胱氨酸%肾功能不全%脑钠肽
慢性心力衰竭%同型半胱氨痠%腎功能不全%腦鈉肽
만성심력쇠갈%동형반광안산%신공능불전%뇌납태
Chronic heart failure%Homocystein%Insufficient renal function%Brain natriuretic peptide
目的：探讨同型半胱氨酸(Hcy)在慢性心力衰竭并肾功能不全患者外周血中的表达。方法选取2013年6月~2014年6月本院心血管内科收治的58例慢性心力衰竭患者作为研究对象,根据患者病情分为慢性心力衰竭合并肾功能不全组(n=28)和慢性心力衰竭组(n=30)。分别予以心脏超声检测左室射血分数(LVEF),酶联免疫吸附法检测血浆脑钠肽(BNP)水平,酶法检测血浆肌酐水平。结果慢性心力衰竭并肾功能不全组的Ⅲ、Ⅳ级患者所占比例显著高于慢性心力衰竭组,LVEF水平显著低于慢性心力衰竭组,外周血Hcy、BNP水平显著高于慢性心力衰竭组,差异有统计学意义(P<0.05)。外周血的Hcy水平与BNP水平和肌酐水平呈明显正相关,与LVEF水平呈负相关。结论 Hcy参与了慢性心力衰竭并肾功能不全的发生、发展,可能是慢性心力衰竭并肾功能不全的潜在干预靶点。
目的：探討同型半胱氨痠(Hcy)在慢性心力衰竭併腎功能不全患者外週血中的錶達。方法選取2013年6月~2014年6月本院心血管內科收治的58例慢性心力衰竭患者作為研究對象,根據患者病情分為慢性心力衰竭閤併腎功能不全組(n=28)和慢性心力衰竭組(n=30)。分彆予以心髒超聲檢測左室射血分數(LVEF),酶聯免疫吸附法檢測血漿腦鈉肽(BNP)水平,酶法檢測血漿肌酐水平。結果慢性心力衰竭併腎功能不全組的Ⅲ、Ⅳ級患者所佔比例顯著高于慢性心力衰竭組,LVEF水平顯著低于慢性心力衰竭組,外週血Hcy、BNP水平顯著高于慢性心力衰竭組,差異有統計學意義(P<0.05)。外週血的Hcy水平與BNP水平和肌酐水平呈明顯正相關,與LVEF水平呈負相關。結論 Hcy參與瞭慢性心力衰竭併腎功能不全的髮生、髮展,可能是慢性心力衰竭併腎功能不全的潛在榦預靶點。
목적：탐토동형반광안산(Hcy)재만성심력쇠갈병신공능불전환자외주혈중적표체。방법선취2013년6월~2014년6월본원심혈관내과수치적58례만성심력쇠갈환자작위연구대상,근거환자병정분위만성심력쇠갈합병신공능불전조(n=28)화만성심력쇠갈조(n=30)。분별여이심장초성검측좌실사혈분수(LVEF),매련면역흡부법검측혈장뇌납태(BNP)수평,매법검측혈장기항수평。결과만성심력쇠갈병신공능불전조적Ⅲ、Ⅳ급환자소점비례현저고우만성심력쇠갈조,LVEF수평현저저우만성심력쇠갈조,외주혈Hcy、BNP수평현저고우만성심력쇠갈조,차이유통계학의의(P<0.05)。외주혈적Hcy수평여BNP수평화기항수평정명현정상관,여LVEF수평정부상관。결론 Hcy삼여료만성심력쇠갈병신공능불전적발생、발전,가능시만성심력쇠갈병신공능불전적잠재간예파점。
Objective To explore the levels of homocystein (Hcy) in patients with chronic heart failure combined insuf-ficient renal function. Methods 58 patients with chronic heart failure in our hospital from June 2013 to June 2014 were selected as the research object.According to patient’s condition,all patients were divided into the chronic heart failure combined insufficient renal function group (n=28) and the chronic heart failure group (n=30).The left ventricular ejec-tion fraction (LVEF) was determined by cardiac ultrasound,the levels of plasma BNP were determined enzyme-linked immuno sorbent assay,the levels of plasma creatine were determined by enzymatic method. Results The proportion of patients of gradeⅢ and gradeⅣ in chronic heart failure and renal insufficiency group was higher than that in chronic heart failure group,the level of LVEF in chronic heart failure and renal insufficiency group was lower than that in chronic heart failure group,the levels of BNP and Hcy in peripheral blood of chronic heart failure and renal insufficien-cy group was higher than that in chronic heart failure group,with significant difference (P<0.05).The levels of plasma Hcy was positively correlated with the levels of plasma BNP and creatine,but negatively correlated with LVEF. Con-clusion Hcy is participated in the development of chronic heart failure concurrence insufficient renal function,which may be a potential target for patients with chronic heart failure combined renal dysfunction.
