CAJ | 학술논문

体外循环是心内直视手术重要的辅助手段，非外科性出血是体外循环心内直视手术后的常见并发症，可危及患者生命。体外循环造成的血小板功能损伤被认为是体外循环心内直视手术后非外科性出血的主要原因。体外循环引起血小板损伤的因素主要包括低温、血液与气体接触、生物相容性、剪切力、鱼精蛋白、肝素、麻醉药物的使用、机血回输、血液稀释、体外循环流转时间等。
체외순배시심내직시수술중요적보조수단，비외과성출혈시체외순배심내직시수술후적상견병발증，가위급환자생명。체외순배조성적혈소판공능손상피인위시체외순배심내직시수술후비외과성출혈적주요원인。체외순배인기혈소판손상적인소주요포괄저온、혈액여기체접촉、생물상용성、전절력、어정단백、간소、마취약물적사용、궤혈회수、혈액희석、체외순배류전시간등。
Cardiopulmonary bypass( CPB) is important to support the circulation during cardiac surgery . Postoperative nonsurgical bleeding of patients undergoing cardiac surgery with CPB is a common complica-tion,which sometimes endangers patient′s life.Platelet dysfunction is considered to be one of the main con-tributors to nonsurgical bleeding after CPB .Contributing factors to platelet dysfunction during CPB include hypothermia,blood-air interaction,biocompatibility,shear stress,protamine,heparin,anaesthetic,hemodilu-tion,duration of operation and shed blood retransfusion.