CAJ | 학술논문

晚期糖基化终产物受体（ RAGE）是细胞表面分子免疫球蛋白超家族受体成员之一，作为一种细胞信号转导受体，与多种配体结合后，激活多种细胞信号转导通路，引起氧化应激和炎症反应等，参与动脉粥样硬化的形成，与2型糖尿病、冠状动脉粥样硬化性心脏病密切相关；可溶性 RAGE是游离的RAGE胞外段，可与 RAGE 配体竞争性的结合，抑制 RAGE 介导的信号传递，拮抗配体－RAGE轴过度活化所致的生物学效应，起保护作用。
만기당기화종산물수체（ RAGE）시세포표면분자면역구단백초가족수체성원지일，작위일충세포신호전도수체，여다충배체결합후，격활다충세포신호전도통로，인기양화응격화염증반응등，삼여동맥죽양경화적형성，여2형당뇨병、관상동맥죽양경화성심장병밀절상관；가용성 RAGE시유리적RAGE포외단，가여 RAGE 배체경쟁성적결합，억제 RAGE 개도적신호전체，길항배체－RAGE축과도활화소치적생물학효응，기보호작용。
The receptor for advanced glycation endproducts(RAGE) is one of the cell surface molecules belonging to the immunoglobulin receptor superfamily.As a signal transduction cell receptor,it activates many cellular signal transduction pathways after binding a variety of ligands ,and then causes oxidative stress and inflammation,which are involved in the formation of atherosclerosis,and closely related with type 2 diabetes mellitus and coronary heart disease.Soluble RAGE,which is the circulating extracellular domain of RAGE may competitively bind the ligands of RAGE,inhibiting the signal transduction mediated by RAGE,reverse the biological effects by the excessive activation of ligand-RAGE axis,playing a protective role.