现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2015年
16期
2415-2416,2420
,共3页
胃溃疡%植物提取物%中草药%模型,动物%大鼠
胃潰瘍%植物提取物%中草藥%模型,動物%大鼠
위궤양%식물제취물%중초약%모형,동물%대서
Stomach ulcer%Plant extracts%Chinese herbal%Models,animal%Rats
目的：通过幽门结扎性胃溃疡模型、醋酸性胃溃疡模型及乙醇致胃溃疡模型研究山橿提取物对溃疡面积的影响。方法选取中南大学湘雅医学院实验动物中心提供的清洁级SD大鼠50只，按随机数字表法分为五组：模型组（等体积蒸馏水）、奥美拉唑组（0.018 g/kg）和山橿提取物组（低、中、高剂量组，1.500、3.500、7.000 g/kg），每组10只，进行相应处理后，比较分析不同剂量山橿提取物对胃溃疡大鼠模型的影响。结果与模型组比较，山橿提取物中、高剂量组均能显著减少胃溃疡面积，其抑制率分别为35.20%和52.94%，且呈良好量效关系，差异均有统计学意义（P<0.01或P<0.05）。结论山橿提取物对大鼠胃溃疡有治疗作用，应对其治疗作用进行更深入的研究。
目的：通過幽門結扎性胃潰瘍模型、醋痠性胃潰瘍模型及乙醇緻胃潰瘍模型研究山橿提取物對潰瘍麵積的影響。方法選取中南大學湘雅醫學院實驗動物中心提供的清潔級SD大鼠50隻，按隨機數字錶法分為五組：模型組（等體積蒸餾水）、奧美拉唑組（0.018 g/kg）和山橿提取物組（低、中、高劑量組，1.500、3.500、7.000 g/kg），每組10隻，進行相應處理後，比較分析不同劑量山橿提取物對胃潰瘍大鼠模型的影響。結果與模型組比較，山橿提取物中、高劑量組均能顯著減少胃潰瘍麵積，其抑製率分彆為35.20%和52.94%，且呈良好量效關繫，差異均有統計學意義（P<0.01或P<0.05）。結論山橿提取物對大鼠胃潰瘍有治療作用，應對其治療作用進行更深入的研究。
목적：통과유문결찰성위궤양모형、작산성위궤양모형급을순치위궤양모형연구산강제취물대궤양면적적영향。방법선취중남대학상아의학원실험동물중심제공적청길급SD대서50지，안수궤수자표법분위오조：모형조（등체적증류수）、오미랍서조（0.018 g/kg）화산강제취물조（저、중、고제량조，1.500、3.500、7.000 g/kg），매조10지，진행상응처리후，비교분석불동제량산강제취물대위궤양대서모형적영향。결과여모형조비교，산강제취물중、고제량조균능현저감소위궤양면적，기억제솔분별위35.20%화52.94%，차정량호량효관계，차이균유통계학의의（P<0.01혹P<0.05）。결론산강제취물대대서위궤양유치료작용，응대기치료작용진행경심입적연구。
Objective To study the influence of extracts from Lindera reflexa Hemsl on the rat ulcer area by the pylorus ligation stomach ulcer model,acetic acid caused stomach ulcer model and ethanol caused stomach ulcer model. Methods Fifty clean grade SD rats provided by the experimental animal center of Xiangya Medical College of Central South University were se lected and randomly divided into 5 groups according to the random number table method:model group(isovolemic distilled water ) , omeprazole group(0.018 g/kg) and Lindera reflexa Hemsl extract group(low,middle and high dose groups,1.500,3.500,7.000 g/kg), 10 rats in each group. After the corresponding treatment ,the influences of different Lindera reflexa Hemsl extract on the stomach ulcer rat model were compared among the different doses. Results Compared with model group,the middle and high Lindera re-flexa Hemsl extract dose groups could significantly reduce the stomach ulcer area ,their inhibition rate on stomach ulcer were 35.20%and 52.94% respectively,moreover which showed a good does dependent manner,the differences were statistically sig nificant(P<0.05). Conclusion The Lindera reflexa Hemsl extract has a treatment effect on stomach ulcer in rats. So the research on its curative effect should be more deeply conducted.
