CAJ | 학술논문

目的：探讨磁共振成像(MRI)采用 T1加权反转恢复(T1WIR)序列在评价婴儿颅脑发育中的应用。方法选择2014年3月~6月在四川大学华西第二医院行颅脑 MRI 检查的28例婴儿为研究对象,对其采用 T1WIR 序列和 T1加权自旋回波(T1WSE)序列进行颅脑轴位扫描(横断层扫描),评价婴儿颅脑发育情况。由2位放射科医师独立对所有 MRI 图像进行髓鞘形成清晰显示情况评分(0~3分),3分为能清晰显示髓鞘形成者。对评分结果进行一致性检验,计算 Kappa 值,并对评分结果进行秩和检验；计算2种序列灰白质对比率(CR)及相对于 T1WSE 序列的 T1WIR 序列灰、白质信号降低率；分别对2种序列 CR 及灰、白质信号降低率进行配对 t 检验。结果①2位放射科医师对 MRI 图像的髓鞘形成清晰显示情况评分结果存在一致性(u=7.887,P =0.000),并且具有相当满意的一致程度(Kappa 值=0.792)；本组28例婴儿采用 T1WIR 序列 MRI 图像的髓鞘形成清晰显示情况评分结果高于 T1WSE 序列,且差异有统计学意义(3分 vs 2分,Z =-3.64,P =0.000)。②T1WIR 序列灰白质 CR 较 T1WSE 序列灰白质 CR 高,且差异有统计学意义[(0.26±0.06)vs (0.05±0.02),t =16.544,P =0.000]；对 T1WSE 序列而言, T1WIR 序列的灰质信号降低率较白质信号降低率低,且差异有统计学意义[(2.03±0.83)vs (2.25±1.26),t=-2.616,P =0.014]。结论采用 T1WIR 序列可取代常规 T1WSE 序列进行 MRI 成像,用于评价婴儿颅脑发育。
목적：탐토자공진성상(MRI)채용 T1가권반전회복(T1WIR)서렬재평개영인로뇌발육중적응용。방법선택2014년3월~6월재사천대학화서제이의원행로뇌 MRI 검사적28례영인위연구대상,대기채용 T1WIR 서렬화 T1가권자선회파(T1WSE)서렬진행로뇌축위소묘(횡단층소묘),평개영인로뇌발육정황。유2위방사과의사독립대소유 MRI 도상진행수초형성청석현시정황평분(0~3분),3분위능청석현시수초형성자。대평분결과진행일치성검험,계산 Kappa 치,병대평분결과진행질화검험；계산2충서렬회백질대비솔(CR)급상대우 T1WSE 서렬적 T1WIR 서렬회、백질신호강저솔；분별대2충서렬 CR 급회、백질신호강저솔진행배대 t 검험。결과①2위방사과의사대 MRI 도상적수초형성청석현시정황평분결과존재일치성(u=7.887,P =0.000),병차구유상당만의적일치정도(Kappa 치=0.792)；본조28례영인채용 T1WIR 서렬 MRI 도상적수초형성청석현시정황평분결과고우 T1WSE 서렬,차차이유통계학의의(3분 vs 2분,Z =-3.64,P =0.000)。②T1WIR 서렬회백질 CR 교 T1WSE 서렬회백질 CR 고,차차이유통계학의의[(0.26±0.06)vs (0.05±0.02),t =16.544,P =0.000]；대 T1WSE 서렬이언, T1WIR 서렬적회질신호강저솔교백질신호강저솔저,차 차 이 유 통 계 학의의[(2.03±0.83)vs (2.25±1.26),t=-2.616,P =0.014]。결론채용 T1WIR 서렬가취대상규 T1WSE 서렬진행 MRI 성상,용우평개영인로뇌발육。
Objective To explore the application of Magnetic Resonance Imaging(MRI)T1 weighted inversion recovery(T1WIR)sequence in evaluation of brain development in infants.Methods A total of 28 infants who accepted MRI examination of brain in West China Second University Hospital,Sichuan University from March to June 2014 were chosen as study subjects.Every infant was underwent both T1WIR and T1 weighted spin echo (T1WSE)sequence in brain transverse axial scanning to evaluate brain development.All MR images were evaluated and scored (0-3 )about myelination by two roentgenologists independently.Images with score of 3 can clearly display myelination.Consistency test was made for the scores between these two roentgenologists.Kappa value was calculated and all scores were underwent rank sum test.Contrast ratio (CR)of grey matter-to-white matter was calculated in both T1WIR and T1WSE sequence.Intensity decreased ratio of T1WIR-to-T1WSE was also calculated in both grey matter and white matter.CR of the two sequences,intensity decreased ratios of grey matter and white matter were all underwent paired t-test.Results ① MR image scores about myelination between the two doctors was consistent(u= 7.887,P = 0.000 )and with a comparatively satisfactory consistent degree (Kappa value =0.792).MR image score about myelination of T1WIR sequence in 28 infants was higher than that of T1WSE sequence,and the difference was significantly (3 points vs 2 points,Z =3.64,P =0.000).② CR of T1WIR sequence was higher than that of T1WSE sequence,and the difference was significantly[(0.26 ±0.06 )vs (0.05 ± 0.02 ),t = 1 6.544,P = 0.000].According to T1WSE sequence,intensity decreased ratio of grey matter in T1WIR sequence was lower than that of white matter,and the difference was significantly[(2.03± 0.83)vs (2.25±1.26),t=2.61 6,P =0.014].Conclusion T1WIR sequence of MRI can substitute T1WSE sequence in evaluation of brain development in infants.