CAJ | 학술논문

目的：探讨不同超声测量指标计算孕龄对中孕期唐氏综合征(DS)筛查效率的影响。方法选择2012年1~12月在四川大学华西第二医院产前诊断中心于中孕期抽血行 DS 筛查的5934例孕妇为研究对象,按照不同孕龄计算方法,将其分为顶臀长组(n=2967,采用早孕期胎儿顶臀长计算孕龄)和双顶径组(n=2967,采用中孕期胎儿双顶径计算孕龄)。对两组 DS 筛查阳性率及 DS 筛查效率进行对比分析。两组孕妇的年龄、体质量等一般临床资料比较,差异无统计学意义(P >0.05)。结果①顶臀长组孕妇接受 DS 筛查主要集中于孕龄为15~17孕周,而双顶径组孕妇接受 DS 筛查的孕龄为15 ~20孕周。②双顶径组的 DS 筛查阳性率(9.80%)高于顶臀长组(6.20%),两组比较,差异有统计学意义(χ2=26.641,P <0.0001)；双顶径组的 DS 筛查效率(1.03%)低于顶臀长组(2.17%),但两组比较,差异无统计学意义(χ2=0.386,P >0.05)。结论早孕期超声检查测量胎儿顶臀长计算孕龄用于中孕期 DS 筛查可能优于中孕期超声检查测量胎儿双顶径计算孕龄方法。
목적：탐토불동초성측량지표계산잉령대중잉기당씨종합정(DS)사사효솔적영향。방법선택2012년1~12월재사천대학화서제이의원산전진단중심우중잉기추혈행 DS 사사적5934례잉부위연구대상,안조불동잉령계산방법,장기분위정둔장조(n=2967,채용조잉기태인정둔장계산잉령)화쌍정경조(n=2967,채용중잉기태인쌍정경계산잉령)。대량조 DS 사사양성솔급 DS 사사효솔진행대비분석。량조잉부적년령、체질량등일반림상자료비교,차이무통계학의의(P >0.05)。결과①정둔장조잉부접수 DS 사사주요집중우잉령위15~17잉주,이쌍정경조잉부접수 DS 사사적잉령위15 ~20잉주。②쌍정경조적 DS 사사양성솔(9.80%)고우정둔장조(6.20%),량조비교,차이유통계학의의(χ2=26.641,P <0.0001)；쌍정경조적 DS 사사효솔(1.03%)저우정둔장조(2.17%),단량조비교,차이무통계학의의(χ2=0.386,P >0.05)。결론조잉기초성검사측량태인정둔장계산잉령용우중잉기 DS 사사가능우우중잉기초성검사측량태인쌍정경계산잉령방법。
Objective To evaluate the influence of gestational age by using different ultrasound examination during second pregnancy trimester for Down syndrome (DS)screening.Methods A total of 5 934 second trimester pregnancies who received DS screening between January and December 2012 at prenatal diagnosis center of West China Second University Hospital,Sichuan University were included into this study.They were divided into two groups according to different methods of estimation of gestational age,crown-rump length group (n=2 967,received ultrasound at 8-14 weeks)and biparietal diameter group (n=2 967,received ultrasound at 14-20 weeks).The positive rate and screening efficiency of DS screening were compared between biparietal diameter group and crown-rump length group.There were no significant differences between two groups in the aspects of age and weight (P >0.05).Results ①Crown-rump length group received DS screening mainly at 1 5-1 7 weeks,and biparietal diameter group received DS screening mainly at 1 5-20 weeks.②The positive rate of biparietal diameter group was significantly higher than that in crown-rump length group (9.8% vs 6.2%),with significant difference (χ2 = 26.641,P < 0.000 1).The screening efficiency of DS screening of biparietal diameter was lower than that in crown-rump length group (1.03% vs 2.1 7%),but there was no significant difference bwteen two groups (χ2 =0.386,P >0.05 ). Conclusions The estimation of gestation age for DS screening using crown-rump length at 8-14 weeks of pregnancy was better than the estimation of gestation age by biparietal diameter at 14-20 weeks.