中华妇幼临床医学杂志（电子版）
中華婦幼臨床醫學雜誌（電子版）
중화부유림상의학잡지（전자판）
CHINESE JOURNAL OF OBSTETRICS & GYNECOLOGY AND PEDIATRICS(ELECTRONIC VERSION)
2015年
4期
521-526
,共6页
王卫凯%杨兰%蔺茹%吴珠明
王衛凱%楊蘭%藺茹%吳珠明
왕위개%양란%린여%오주명
低出生体质量儿%生育史%病例对照研究%logistic 回归
低齣生體質量兒%生育史%病例對照研究%logistic 迴歸
저출생체질량인%생육사%병례대조연구%logistic 회귀
Low birth weight infant%Reproductive history%Case-control studies%Logistic regression
目的：探讨母亲既往生育史对低出生体质量(LBW)儿发生的影响。方法选择2009年2月至2010年12月于甘肃省妇幼保健院产科娩出的375例 LBW 儿为研究对象,纳入 LBW 儿组(n =375)。选择同期于本院产科娩出的5157例正常出生体质量儿为对照组(n=5157)。本研究遵循的程序符合甘肃省妇幼保健院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象监护人的知情同意,并与之签署临床研究知情同意书。比较两组母亲既往生育史对 LBW 儿发生的影响。结果①既往有怀孕史(孕次≥1时 OR=1.46,95%CI ：1.18~1.81；孕次≥2时 OR =1.80,95%CI ：1.40~2.32)、生产史(产次=1时 OR=1.65,95%CI ：1.29~2.11；产次≥2时 OR=2.68,95%CI ：1.71~4.20)、多次(≥2次)自然流产史(OR=2.70,95%CI ：1.67~4.35)、既往分娩早产儿(OR =6.32,95%CI ：2.86~13.97)、分娩LBW 儿史(OR=4.62,95%CI ：1.48~14.40)及不良孕产史(OR=3.26,95%CI ：2.07~5.14)均是 LBW 儿发生的危险因素。而既往多次自然流产史(aOR=1.08；95%CI ：0.49~2.39)、分娩早产儿史(aOR =1.00,95%CI ：0.31~3.19)与不良孕产史(aOR =1.51,95%CI ：0.64~3.55)是 LBW 儿发生的独立危险因素。②孕次、产次、自然流产史、分娩早产儿史及不良孕产史均是早产 LBW 儿发生的危险因素(OR=1.72,95%CI ：1.34~2.20；OR =1.99,95%CI ：1.54~2.58；OR =1.80,95%CI ：1.30~ 2.50；OR =8.32,95%CI ：3.75~18.43；OR=3.57,95%CI ：2.18~5.85)。既往分娩 LBW 儿是足月 LBW 儿的独立危险因素(aOR =7.93,95%CI ：1.72~36.46)。结论LBW 儿的发生与母亲的孕次、产次、多次自然流产史、既往分娩 LBW儿等生育史有密切关系,而与既往分娩早产儿史、不良孕产史等相关性较小。对上述妇女再次怀孕时,应做好孕前、孕期保健服务,以有效减少 LBW 的发生。
目的：探討母親既往生育史對低齣生體質量(LBW)兒髮生的影響。方法選擇2009年2月至2010年12月于甘肅省婦幼保健院產科娩齣的375例 LBW 兒為研究對象,納入 LBW 兒組(n =375)。選擇同期于本院產科娩齣的5157例正常齣生體質量兒為對照組(n=5157)。本研究遵循的程序符閤甘肅省婦幼保健院人體試驗委員會所製定的倫理學標準,得到該委員會批準,分組徵得受試對象鑑護人的知情同意,併與之籤署臨床研究知情同意書。比較兩組母親既往生育史對 LBW 兒髮生的影響。結果①既往有懷孕史(孕次≥1時 OR=1.46,95%CI ：1.18~1.81；孕次≥2時 OR =1.80,95%CI ：1.40~2.32)、生產史(產次=1時 OR=1.65,95%CI ：1.29~2.11；產次≥2時 OR=2.68,95%CI ：1.71~4.20)、多次(≥2次)自然流產史(OR=2.70,95%CI ：1.67~4.35)、既往分娩早產兒(OR =6.32,95%CI ：2.86~13.97)、分娩LBW 兒史(OR=4.62,95%CI ：1.48~14.40)及不良孕產史(OR=3.26,95%CI ：2.07~5.14)均是 LBW 兒髮生的危險因素。而既往多次自然流產史(aOR=1.08；95%CI ：0.49~2.39)、分娩早產兒史(aOR =1.00,95%CI ：0.31~3.19)與不良孕產史(aOR =1.51,95%CI ：0.64~3.55)是 LBW 兒髮生的獨立危險因素。②孕次、產次、自然流產史、分娩早產兒史及不良孕產史均是早產 LBW 兒髮生的危險因素(OR=1.72,95%CI ：1.34~2.20；OR =1.99,95%CI ：1.54~2.58；OR =1.80,95%CI ：1.30~ 2.50；OR =8.32,95%CI ：3.75~18.43；OR=3.57,95%CI ：2.18~5.85)。既往分娩 LBW 兒是足月 LBW 兒的獨立危險因素(aOR =7.93,95%CI ：1.72~36.46)。結論LBW 兒的髮生與母親的孕次、產次、多次自然流產史、既往分娩 LBW兒等生育史有密切關繫,而與既往分娩早產兒史、不良孕產史等相關性較小。對上述婦女再次懷孕時,應做好孕前、孕期保健服務,以有效減少 LBW 的髮生。
목적：탐토모친기왕생육사대저출생체질량(LBW)인발생적영향。방법선택2009년2월지2010년12월우감숙성부유보건원산과면출적375례 LBW 인위연구대상,납입 LBW 인조(n =375)。선택동기우본원산과면출적5157례정상출생체질량인위대조조(n=5157)。본연구준순적정서부합감숙성부유보건원인체시험위원회소제정적윤리학표준,득도해위원회비준,분조정득수시대상감호인적지정동의,병여지첨서림상연구지정동의서。비교량조모친기왕생육사대 LBW 인발생적영향。결과①기왕유부잉사(잉차≥1시 OR=1.46,95%CI ：1.18~1.81；잉차≥2시 OR =1.80,95%CI ：1.40~2.32)、생산사(산차=1시 OR=1.65,95%CI ：1.29~2.11；산차≥2시 OR=2.68,95%CI ：1.71~4.20)、다차(≥2차)자연유산사(OR=2.70,95%CI ：1.67~4.35)、기왕분면조산인(OR =6.32,95%CI ：2.86~13.97)、분면LBW 인사(OR=4.62,95%CI ：1.48~14.40)급불량잉산사(OR=3.26,95%CI ：2.07~5.14)균시 LBW 인발생적위험인소。이기왕다차자연유산사(aOR=1.08；95%CI ：0.49~2.39)、분면조산인사(aOR =1.00,95%CI ：0.31~3.19)여불량잉산사(aOR =1.51,95%CI ：0.64~3.55)시 LBW 인발생적독립위험인소。②잉차、산차、자연유산사、분면조산인사급불량잉산사균시조산 LBW 인발생적위험인소(OR=1.72,95%CI ：1.34~2.20；OR =1.99,95%CI ：1.54~2.58；OR =1.80,95%CI ：1.30~ 2.50；OR =8.32,95%CI ：3.75~18.43；OR=3.57,95%CI ：2.18~5.85)。기왕분면 LBW 인시족월 LBW 인적독립위험인소(aOR =7.93,95%CI ：1.72~36.46)。결론LBW 인적발생여모친적잉차、산차、다차자연유산사、기왕분면 LBW인등생육사유밀절관계,이여기왕분면조산인사、불량잉산사등상관성교소。대상술부녀재차부잉시,응주호잉전、잉기보건복무,이유효감소 LBW 적발생。
Objective To explore the influence of previous reproductive history on low birth weight (LBW)infants.Methods From February 2009 to December 2010,a total of 375 hospitalized LBW infants were included in the study as LBW group(n=375).Meanwhile 5 1 57 normal birth weight infants in the same hospital were chosen as control group (n=5 1 57).The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Gansu Provincial Maternity and Child-care Hospital.Informed consent was obtained from each participants′ parents.The effects of the pregnancy previous reproductive history were compared between two groups.Results ① The gravidity(gravidity≥ 1,OR = 1.46,95%CI :1.18-1.81;gravidity≥2,OR=1.80,95%CI :1.40-2.32),parity(parity=1,OR =1.65,95%CI :1.29-2.1 1;parity≥2,OR=2.68,95%CI :1.71-4.20),multiple spontaneous abortion history (OR=2.70 95%CI :1.67-4.35),previous delivery history of preterm infants (OR=6.31,95%CI :2.86-13.97)and LBW infants(OR=4.62,95%CI :1.48-14.40),adverse pregnancy history(OR =3.26,95%CI :2.07-5.14)were risk factors of LBW.The multiple spontaneous abortion history (aOR = 1.08,95%CI :0.49-2.39 ),previous delivery history of preterm infants (aOR=1.00,95%CI :0.31-3.1 9)and adverse pregnancy history(aOR=1.5;95%CI :0.64-3.55)were the independent risk factors of LBW.②The gravidity,parity,spontaneous abortion history,previous delivery history of preterm infants and adverse pregnancy history were the risk factors of preterm infants with LBW (OR=1.72,95%CI :1.34-2.20;OR=1.99,95%CI :1.54-2.58;OR=1.80, 95%CI :1.30-2.50;OR=8.32,95%CI :3.75-18.43;OR = 3.57,95%CI :2.18-5.85 ).The independent risk factors of term infants with LBW was previous delivery history of LBW infants(aOR =7.93,95%CI :1.72-36.46).Conclusions The occurrence of LBW infants had strong relationship with the previous reproductive history of their mother,such as gravidity,parity,mutiple spontaneous abortion history,previous delivery history of LBW infants,and had little relationship with spontaneous abortion history,previous delivery history of preterm infants,adverse pregnancy.The woman who had risk factors of LBW is pregnant again, should do well in pregnancy,prenatal care services,in order to effectively reduce the occurrence of LBW.
