中国卫生产业
中國衛生產業
중국위생산업
CHINA HEALTH INDUSTRY
2015年
12期
9-11,22
,共4页
候素君%李建新%王新玲%周绪云
候素君%李建新%王新玲%週緒雲
후소군%리건신%왕신령%주서운
医院感染%病原菌%耐药性%抗菌药物
醫院感染%病原菌%耐藥性%抗菌藥物
의원감염%병원균%내약성%항균약물
Nosocomial infection Pathogenic bacteria%Drug resistance%Antibacterials
目的：分析医院2011要2014年医院感染病原菌分布及耐药性，以便指导用药，加强医院感染监测和预防。方法对医院2011年1月-2014年12月临床标本中分离的5185株病原菌的分布及耐药性进行统计和分析，数据应用WHONET5.6软件进行统计分析。结果革兰阳性球菌816株占15.74%，革兰阴性杆菌3574株占68.93%，真菌795株占15.33%；革兰阳性球菌以金黄色葡萄球菌为主，对青霉素、红霉素、克林霉素耐药率>80%，未发现万古霉素耐药株；革兰阴性杆菌以大肠埃希氏菌、铜绿假单胞菌、肺炎克雷伯氏菌、鲍曼不动杆菌为主，具有多药耐药性，其中以鲍曼不动杆菌更为显著；真菌以白色念珠菌为主，对5-氟胞嘧啶、氟康唑、伊曲康唑、伏立康唑几乎全敏感。结论医院感染病原菌中革兰阴性杆菌呈增高趋势，对常用抗菌药物耐药性高，定期进行细菌耐药性监测，根据药敏试验选择抗菌药物对有效的治疗及耐药菌株的减少有重要意义。
目的：分析醫院2011要2014年醫院感染病原菌分佈及耐藥性，以便指導用藥，加彊醫院感染鑑測和預防。方法對醫院2011年1月-2014年12月臨床標本中分離的5185株病原菌的分佈及耐藥性進行統計和分析，數據應用WHONET5.6軟件進行統計分析。結果革蘭暘性毬菌816株佔15.74%，革蘭陰性桿菌3574株佔68.93%，真菌795株佔15.33%；革蘭暘性毬菌以金黃色葡萄毬菌為主，對青黴素、紅黴素、剋林黴素耐藥率>80%，未髮現萬古黴素耐藥株；革蘭陰性桿菌以大腸埃希氏菌、銅綠假單胞菌、肺炎剋雷伯氏菌、鮑曼不動桿菌為主，具有多藥耐藥性，其中以鮑曼不動桿菌更為顯著；真菌以白色唸珠菌為主，對5-氟胞嘧啶、氟康唑、伊麯康唑、伏立康唑幾乎全敏感。結論醫院感染病原菌中革蘭陰性桿菌呈增高趨勢，對常用抗菌藥物耐藥性高，定期進行細菌耐藥性鑑測，根據藥敏試驗選擇抗菌藥物對有效的治療及耐藥菌株的減少有重要意義。
목적：분석의원2011요2014년의원감염병원균분포급내약성，이편지도용약，가강의원감염감측화예방。방법대의원2011년1월-2014년12월림상표본중분리적5185주병원균적분포급내약성진행통계화분석，수거응용WHONET5.6연건진행통계분석。결과혁란양성구균816주점15.74%，혁란음성간균3574주점68.93%，진균795주점15.33%；혁란양성구균이금황색포도구균위주，대청매소、홍매소、극림매소내약솔>80%，미발현만고매소내약주；혁란음성간균이대장애희씨균、동록가단포균、폐염극뢰백씨균、포만불동간균위주，구유다약내약성，기중이포만불동간균경위현저；진균이백색념주균위주，대5-불포밀정、불강서、이곡강서、복립강서궤호전민감。결론의원감염병원균중혁란음성간균정증고추세，대상용항균약물내약성고，정기진행세균내약성감측，근거약민시험선택항균약물대유효적치료급내약균주적감소유중요의의。
Objective To analyse the distribution and drug resistance of the common pathogens from 2011 to 2014 in our hospital so as to guide the rational clinical application of antibiotics, strengthening the monitor and prevention of hospital infections. Methods Retrospectively analyzed the distribution and drug resistance of 5185 strains of pathogens isolated from clicnical speci-mens from January 2012 to December 2014. And the results of the drug susceptibility testing were statistically analyzed by means of Whonet 5.6 software. Results A total of 5185 pathogens isolated from clicnical specimens included 816 (15.74%) strains of gram-positive cocci, 3574 (68.93%) strains of gram-negative bacilli, and 795 (15.33%) strains of fungi. The most important strain of gram-positive cocci is Staphylococcu aureus. Resistant to Penicillin, erythromycin, clindamycin is 80% or more, and no strains resistant to vancomycin were found. Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonlae, Acinetobacter baumannii are most commonly enncountered gram-negative bacilli of infections. These bacilli are a multidrug resistant in which Acinetobacter baumannii is particular notable. Conclusion Gram-negative bacilli of opportunistic pathogen in hosital have a general increase on the number and drug resistance to common antibiotics. Therefore, it is of great significance to regular monitor of bacterial resis-tance detect, and it also will contribute to effective clinical treatment and reduction of drug-resistant strains on the basis of the reasonable clinical use of antibiotics.
