CAJ | 학술논문

目的：采用随机双盲、安慰剂对照的前瞻性研究，评估服用胶原蛋白肽Peptan对中老年女性膝骨关节炎患者的效果。方法100例膝骨关节炎患者随机分成两组，试验组服用胶原蛋白肽Peptan 8 g/d，安慰剂组服用麦芽糊精8 g/d，连续服用6个月。应用WOMAC评分和Lysholm评分来评估治疗前后骨关节疼痛和功能改善状况。结果（1）服用6个月Peptan组WOMAC评分（11.33±4.28）明显低于安慰剂组（15.00±3.45，P＜0.001）；Peptan组Lysholm评分（85.24±8.88）明显高于安慰剂组（79.73±9.62，P＜0.001）；（2）两组WOMAC评分和 Lysholm 评分治疗前后的差值具有明显统计学差异（P＜0.001）；（3）服用6个月Peptan组的临床效果（关节疼痛好转和功能恢复情况）明显优于安慰剂组（P＜0.001）。结论口服胶原蛋白肽Peptan能有效地改善中老年膝骨关节炎女性患者的关节功能，缓解疼痛，改善生活质量。
목적：채용수궤쌍맹、안위제대조적전첨성연구，평고복용효원단백태Peptan대중노년녀성슬골관절염환자적효과。방법100례슬골관절염환자수궤분성량조，시험조복용효원단백태Peptan 8 g/d，안위제조복용맥아호정8 g/d，련속복용6개월。응용WOMAC평분화Lysholm평분래평고치료전후골관절동통화공능개선상황。결과（1）복용6개월Peptan조WOMAC평분（11.33±4.28）명현저우안위제조（15.00±3.45，P＜0.001）；Peptan조Lysholm평분（85.24±8.88）명현고우안위제조（79.73±9.62，P＜0.001）；（2）량조WOMAC평분화 Lysholm 평분치료전후적차치구유명현통계학차이（P＜0.001）；（3）복용6개월Peptan조적림상효과（관절동통호전화공능회복정황）명현우우안위제조（P＜0.001）。결론구복효원단백태Peptan능유효지개선중노년슬골관절염녀성환자적관절공능，완해동통，개선생활질량。
Objective Using a double-blind, randomized, placebo-controled study for evaluating effectivity of oral Peptan colagen peptides treatment in female patients with knee osteoarthritis (OA).Methods100 patients were randomly assigned to two groups, respectively taking Peptan? collagen peptides (CP) 8 g (n=50) or placebo (n=50) daily for 6 months. Each subject was evaluated for knee joint pain and function by using the standard tools (WOMAC scores and Lysholm scores). Results(1)CP groupvs. placebo group, WOMAC scores were lower (11.33±4.28vs. 15.00±3.45), and Lysholm scores were higher (85.24±8.88vs. 79.73±9.62) for 6 months (P<0.001); (2)The difference of WOMAC score and Lysholm score of post- and pre-study between CP group and placebo group was statisticaly significant (P<0.001); (3)The proportion of clinical effect was also found significant difference between the placebo group and the CP group for 6 months (P<0.001).Conclusion Oral Peptan colagen peptides can effectively improve patients’ knee osteoarthritis function, reduce joint pain and improve the quality of life.