中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2015年
15期
2916-2919
,共4页
胰腺肿瘤%蛋白质组学%诊断
胰腺腫瘤%蛋白質組學%診斷
이선종류%단백질조학%진단
Pancreatic neoplasms%Proteomics%Diagnosis
胰腺癌缺乏早期特异性症状，恶性程度极高，早期就有局部侵犯和转移。手术切除是根治胰腺癌的唯一方法。胰腺癌的早期诊断已经成为实施有效治疗，提高根治性手术切除率以及延长术后生存率的关键所在，也就成为国内外研究的热点和难点。肿瘤的早期诊断是蛋白质组学在肿瘤研究中应用较多的一个领域。利用SELDI-TOF-MS技术和芯片能发现胰腺癌患者血清中的特征蛋白，对胰腺癌的早期诊断具有重要意义。本文就蛋白质组学对于胰腺癌的早期诊断的研究进展进行简要阐述。
胰腺癌缺乏早期特異性癥狀，噁性程度極高，早期就有跼部侵犯和轉移。手術切除是根治胰腺癌的唯一方法。胰腺癌的早期診斷已經成為實施有效治療，提高根治性手術切除率以及延長術後生存率的關鍵所在，也就成為國內外研究的熱點和難點。腫瘤的早期診斷是蛋白質組學在腫瘤研究中應用較多的一箇領域。利用SELDI-TOF-MS技術和芯片能髮現胰腺癌患者血清中的特徵蛋白，對胰腺癌的早期診斷具有重要意義。本文就蛋白質組學對于胰腺癌的早期診斷的研究進展進行簡要闡述。
이선암결핍조기특이성증상，악성정도겁고，조기취유국부침범화전이。수술절제시근치이선암적유일방법。이선암적조기진단이경성위실시유효치료，제고근치성수술절제솔이급연장술후생존솔적관건소재，야취성위국내외연구적열점화난점。종류적조기진단시단백질조학재종류연구중응용교다적일개영역。이용SELDI-TOF-MS기술화심편능발현이선암환자혈청중적특정단백，대이선암적조기진단구유중요의의。본문취단백질조학대우이선암적조기진단적연구진전진행간요천술。
Pancreatic cancer is characterized by the lack of early specific symptoms and higher degree of malignancy and local invasion and metastasis in the early stage. Surgical resection is the only way to cure pancreatic cancer. Early diagnosis of pancreatic cancer has become the key to effective treatment and improve the curative resection rate and prolong survival rate, and has become a hot spot and difficulty in domestic and international research. Early diagnosis of cancer proteomics in cancer research is the application of a large field. Combination of SELDI-TOF-MS with protein chips may provides a new proteomics mode for laboratory diagnosis of pancreatic cancer. These specific biomarkers are potential tools for early diagnosis of pancreatic cancer. This review focused on advances in proteome research for pancreatic cancer early diagnosis.
