中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2015年
15期
2892-2896
,共5页
高血压,肺性%内皮祖细胞%治疗
高血壓,肺性%內皮祖細胞%治療
고혈압,폐성%내피조세포%치료
Hypertension,pulmonary%Endothelial progenitor cells%Treatment
肺动脉高压是一种由已知或未知原因引起的以肺血管收缩、重构、原位血栓形成为主要病变特征,肺血管阻力进行性升高及血流受限,肺动脉压力异常升高的病理生理综合征,最终可导致右心功能受损,甚至死亡。恢复血管内皮结构和功能的完整性,逆转肺血管重构,促进血管新生替代永久性闭塞血管是治疗肺动脉高压的关键。近年研究发现,内皮祖细胞在维持血管内稳态、逆转肺血管重构及促进血管新生方面有重大意义,本文就肺动脉高压的内皮祖细胞治疗作一综述。
肺動脈高壓是一種由已知或未知原因引起的以肺血管收縮、重構、原位血栓形成為主要病變特徵,肺血管阻力進行性升高及血流受限,肺動脈壓力異常升高的病理生理綜閤徵,最終可導緻右心功能受損,甚至死亡。恢複血管內皮結構和功能的完整性,逆轉肺血管重構,促進血管新生替代永久性閉塞血管是治療肺動脈高壓的關鍵。近年研究髮現,內皮祖細胞在維持血管內穩態、逆轉肺血管重構及促進血管新生方麵有重大意義,本文就肺動脈高壓的內皮祖細胞治療作一綜述。
폐동맥고압시일충유이지혹미지원인인기적이폐혈관수축、중구、원위혈전형성위주요병변특정,폐혈관조력진행성승고급혈류수한,폐동맥압력이상승고적병리생리종합정,최종가도치우심공능수손,심지사망。회복혈관내피결구화공능적완정성,역전폐혈관중구,촉진혈관신생체대영구성폐새혈관시치료폐동맥고압적관건。근년연구발현,내피조세포재유지혈관내은태、역전폐혈관중구급촉진혈관신생방면유중대의의,본문취폐동맥고압적내피조세포치료작일종술。
Pulmonary hypertension is a disease characterized by pulmonary vasoconstriction, pulmonary vascular remodeling andin situ thrombosis, resulting in pulmonary vascular resistance increasing and blood flow restriction, pulmonary artery pressure elevating, eventually leading to right heart dysfunction, even death. Remedy of the integrity of endothelial structure and function, pulmonary vascular remodeling, angiogenesis replace permanent vascular occlusion, is the key to the treatment of pulmonary hypertension. Recent studies have found that endothelial progenitor cells (EPCs) play an important role in maintaining vascular homeostasis and reversal pulmonary vascular remodeling and promote angiogenesis, this article made a summary on the EPCs for the treatment of pulmonary hypertension.