CAJ | 학술논문

目的：探讨阿尔茨海默病（ AD）与血管性痴呆（ VD）的血管危险因素及相关基因的多态性。方法对比分析104例AD患者，85例VD患者及130例正常对照组的血管危险因子和载脂蛋白E（ ApoE）基因、亚甲基四氢叶酸还原酶（ MTH－FR）基因多态性。结果①VD组患者高血压、糖尿病、高低密度脂蛋白（LDL）血症发生率高于AD组（P＜0．05）；AD组患者高血压、糖尿病发生率高于对照组（P＜0．05）；VD组患者高血压、糖尿病、高LDL、高Hcy发生率高于对照组（P＜0．05）。②AD组、VD组与对照组ApoE基因型构成及等位基因频率比较差异有统计学意义（ P＜0．01）。③AD组、VD组与对照组MTHFR基因型构成及等位基因频率比较差异无统计学意义（ P＞0．05）。结论高血压、糖尿病、高低密度脂蛋白血症、高Hcy与VD发病关系密切，高血压、糖尿病与AD发病也相关；ApoEε4基因型不仅是AD发生的危险因素，也是VD发生的危险因素；MTHFR的基因多态与AD、VD发生无明显相关性。
목적：탐토아이자해묵병（ AD）여혈관성치태（ VD）적혈관위험인소급상관기인적다태성。방법대비분석104례AD환자，85례VD환자급130례정상대조조적혈관위험인자화재지단백E（ ApoE）기인、아갑기사경협산환원매（ MTH－FR）기인다태성。결과①VD조환자고혈압、당뇨병、고저밀도지단백（LDL）혈증발생솔고우AD조（P＜0．05）；AD조환자고혈압、당뇨병발생솔고우대조조（P＜0．05）；VD조환자고혈압、당뇨병、고LDL、고Hcy발생솔고우대조조（P＜0．05）。②AD조、VD조여대조조ApoE기인형구성급등위기인빈솔비교차이유통계학의의（ P＜0．01）。③AD조、VD조여대조조MTHFR기인형구성급등위기인빈솔비교차이무통계학의의（ P＞0．05）。결론고혈압、당뇨병、고저밀도지단백혈증、고Hcy여VD발병관계밀절，고혈압、당뇨병여AD발병야상관；ApoEε4기인형불부시AD발생적위험인소，야시VD발생적위험인소；MTHFR적기인다태여AD、VD발생무명현상관성。
Objectives The aim of this study was to investigate the cardiovascular risk factors in patients who were diagnosed with Alzheimer Dementia(AD) and Vascular Dementia(VD).Methods A total of 319 people were enrolled,with 104 AD pa-tients, 85 VD patients and 130 normal control people.We studied the association of cardiovascular risk factors and gene polymor-phism in these groups.Results ①The incidence of hypertension,diabetes,hyperlipidemia were significantly different between AD group and VD group.The incidence of hypertension,diabetes,hyperlipidemia,hypotension and hyperhomocystinemia(HHcy) in AD group and VD group were significantly different compared to the control group.②The ApoE genetype and allele frequency were sig-nificantly different among AD group,VD group and the control group,especially inε4 ( P<0.05).③There were no difference among AD group,VD group and the control group in the MTHFR polymorphism (P>0.05).Conclusions Our study showed that hyper-tension,diabetes,hyperlipidemia may play a role in VD.ApoEε4 was one risk factor in both VD and AD, and the MTHFR polymor-phism had no obvious correlation between VD and AD.