CAJ | 학술논문

目的：了解某部新兵麻疹免疫水平及麻疹-腮腺炎-风疹联合疫苗( MMR)接种后麻疹抗体的免疫效果,为部队制定麻疹免疫方案提供理论依据。方法选择新入伍的300名新兵,在MMR接种前与接种后检测麻疹IgG抗体水平及抗体阳性率,并对不同年龄(17~18、19~20、21~22岁)、不同籍贯(四川、山东、天津、北京、湖北、安徽、内蒙古等)、不同文化程度(初中及中专学历、高中学历、大专及以上学历)新兵进行抗体水平统计。结果300名新兵MMR接种前麻疹IgG抗体平均滴度为678.42 mU/ml、抗体阳性率为47.67%,接种后麻疹IgG抗体平均滴度为1699.41 mU/ml、抗体阳性率为98.00%,总阳转率为96.2%,接种前后IgG抗体滴度差异有统计学意义( t=9.543, P<0．01)。不同年龄、籍贯、文化程度新兵抗体阳性率差异无统计学意义(P>0．05)。本次免疫共报告预防接种异常反应14例,其中轻度发热2例,局部疼痛4例,接种部位发痒、红肿、疼痛8例(其中伴发热1例)。结论该部接种MMR后麻疹IgG抗体水平显著上升,接种效果良好。建议部队做好麻疹抗体监测及麻疹病例监测报告工作。
목적：료해모부신병마진면역수평급마진-시선염-풍진연합역묘( MMR)접충후마진항체적면역효과,위부대제정마진면역방안제공이론의거。방법선택신입오적300명신병,재MMR접충전여접충후검측마진IgG항체수평급항체양성솔,병대불동년령(17~18、19~20、21~22세)、불동적관(사천、산동、천진、북경、호북、안휘、내몽고등)、불동문화정도(초중급중전학력、고중학력、대전급이상학력)신병진행항체수평통계。결과300명신병MMR접충전마진IgG항체평균적도위678.42 mU/ml、항체양성솔위47.67%,접충후마진IgG항체평균적도위1699.41 mU/ml、항체양성솔위98.00%,총양전솔위96.2%,접충전후IgG항체적도차이유통계학의의( t=9.543, P<0．01)。불동년령、적관、문화정도신병항체양성솔차이무통계학의의(P>0．05)。본차면역공보고예방접충이상반응14례,기중경도발열2례,국부동통4례,접충부위발양、홍종、동통8례(기중반발열1례)。결론해부접충MMR후마진IgG항체수평현저상승,접충효과량호。건의부대주호마진항체감측급마진병례감측보고공작。
Objective To investigate the morbillous immunization levels and antibody 's immunization effect of recruits in some PLA unit after measles-mumps-rubella combined vaccine ( MMR) vaccination so as to provide the theo-retical basis for establishing immunization plan of rubella vaccine for the troops. Methods Levels and positive rate of morbillous immunoglobulin G ( IgG) antibody of 300 recruits before and after the MMR inoculation were detected, and antibody levels of recruits in different ages groups (17-18, 19-20, 21-22), different places of birth (Sichuan, Shandong, Tianjin, Beijing, Hubei, Anhui, Inner Mongolia and so on), different education levels (junior and secondary education, high school education, college and university education) were analyzed. Results The antibody's average titer and posi-tive rate of 300 recruits were 678. 42 mU/ml and 47. 67% before the inoculation, and 1699. 41 mU/ml and 98. 00% af-ter the inoculation. The total seroconversion rate was 96. 2%, and the difference in antibody's average titer before and af-ter the inoculation was statistically significant (t=9. 543, P<0. 01). There were no significant differences in the anti-body's positive rate of recruits with different ages, places of birth and educations (P>0. 05). A total of 14 recruits had abnormal reaction after the inoculation, 2 recruits with mild fever, 4 recruits with local pain, 8 recruits with itchy redness or pain in vaccination position (1 recruit complicated by fever). Conclusion The morbillous IgG antibody levels of the recruits in the PLA unit can be significantly increased after MRR inoculation with good effect. Antibody level monitoring and case reporting of measles should be implemented in troops.