中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2015年
20期
2454-2457
,共4页
疏血通注射液%胃肠出血%合并用药%药物相互作用%抗血栓形成药
疏血通註射液%胃腸齣血%閤併用藥%藥物相互作用%抗血栓形成藥
소혈통주사액%위장출혈%합병용약%약물상호작용%항혈전형성약
Shuxuetong injection%Gastrointestinal hemorrhage%Drug combinations%Drug interactions%Fibrinolytic agents
目的对疑似因疏血通注射液用药期间致上消化道出血患者的病历资料进行分析，为临床合理用药提供参考。方法回顾性分析海南医学院附属医院2010年1月—2013年6月1876份临床应用疏血通注射液的住院患者的病历资料，其中4例在疏血通注射液用药期间出现上消化道出血，分析其出血与应用疏血通注射液的相关性。结果发生上消化道出血的4 例患者均>70 岁；4 例患者与疏血通注射液合并应用的药物除阿司匹林肠溶片外，还包括参芎葡萄糖注射液、芪蛭通络胶囊、红花黄色素注射液等抗栓药物，合并用药3 ～6 d 后出现黑便、腹胀、腹痛、呕血等上消化道出血症状，停药和抑酸治疗4 ～9 d 后出血症状好转或痊愈。结论 疏血通注射液合并用药可能引起上消化道出血，合并用药导致出血可能与阿司匹林等抗栓药物有关，临床应警惕多种中西抗栓药物的联合应用有导致出血的可能性。
目的對疑似因疏血通註射液用藥期間緻上消化道齣血患者的病歷資料進行分析，為臨床閤理用藥提供參攷。方法迴顧性分析海南醫學院附屬醫院2010年1月—2013年6月1876份臨床應用疏血通註射液的住院患者的病歷資料，其中4例在疏血通註射液用藥期間齣現上消化道齣血，分析其齣血與應用疏血通註射液的相關性。結果髮生上消化道齣血的4 例患者均>70 歲；4 例患者與疏血通註射液閤併應用的藥物除阿司匹林腸溶片外，還包括參芎葡萄糖註射液、芪蛭通絡膠囊、紅花黃色素註射液等抗栓藥物，閤併用藥3 ～6 d 後齣現黑便、腹脹、腹痛、嘔血等上消化道齣血癥狀，停藥和抑痠治療4 ～9 d 後齣血癥狀好轉或痊愈。結論 疏血通註射液閤併用藥可能引起上消化道齣血，閤併用藥導緻齣血可能與阿司匹林等抗栓藥物有關，臨床應警惕多種中西抗栓藥物的聯閤應用有導緻齣血的可能性。
목적대의사인소혈통주사액용약기간치상소화도출혈환자적병력자료진행분석，위림상합리용약제공삼고。방법회고성분석해남의학원부속의원2010년1월—2013년6월1876빈림상응용소혈통주사액적주원환자적병력자료，기중4례재소혈통주사액용약기간출현상소화도출혈，분석기출혈여응용소혈통주사액적상관성。결과발생상소화도출혈적4 례환자균>70 세；4 례환자여소혈통주사액합병응용적약물제아사필림장용편외，환포괄삼궁포도당주사액、기질통락효낭、홍화황색소주사액등항전약물，합병용약3 ～6 d 후출현흑편、복창、복통、구혈등상소화도출혈증상，정약화억산치료4 ～9 d 후출혈증상호전혹전유。결론 소혈통주사액합병용약가능인기상소화도출혈，합병용약도치출혈가능여아사필림등항전약물유관，림상응경척다충중서항전약물적연합응용유도치출혈적가능성。
Objective To analyze the data of upper gastrointestinal hemorrhage suspected cases that occur during the course of Shuxuetong injection,to provide references for rational drug use. Methods We retrospectively examined the clinical data of 1 876 patients using Shuxuetong injection in the Affiliated Hospital of Hainan Medical University from January 2010 to June 2013. Upper gastrointestinal hemorrhage occurred during the shuxuetong injection. The correlation between the gastrointestinal hemorrhage and the application of Shuxuetong injection was analyzed. Results The four patients suffering upper gastrointestinal hemorrhage were all over 70 years old. Apart from aspirin enteric coated tablets,Shuxuetong injection was also combined with Salviae Miltiorrhizae Liguspyragine Hydrochloride and Glucose injection,Qizhitongluo capsule,Safflower yellow injection and other antithrombotic drugs. Three to six days after the administration of the combined drugs,symptoms of upper gastrointestinal hemorrhage appeared, including black stool, abdominal distension, abdominal pain, hematemesis, etc. The symptoms reduced or recovered four to nine days after the drug withdrawal and the use of acid inhibitors. Conclusion Shuxuetong injetion combined with other medications may cause upper gastrointestinal hemorrhage. Drug combination may be related with antithrombotic drugs, like aspirin. Combined application of Chinese and western antithrombotic drugs should be carefully conducted in clinical practice.
