中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2015年
20期
2393-2397
,共5页
陈丹%王淑霞%刘静%刘风莲%赵卫云%程志琴%高颖
陳丹%王淑霞%劉靜%劉風蓮%趙衛雲%程誌琴%高穎
진단%왕숙하%류정%류풍련%조위운%정지금%고영
甲状腺结节%代谢综合征X%汉族%维吾尔族%哈萨克族
甲狀腺結節%代謝綜閤徵X%漢族%維吾爾族%哈薩剋族
갑상선결절%대사종합정X%한족%유오이족%합살극족
Thyroid nodule%Metabolic syndrome X%Han nationality%Uygur nationality%Kazakh nationality
目的:探讨汉族、维吾尔族及哈萨克族甲状腺结节与代谢综合征( MS)的相关性。方法选取2013年新疆医科大学第一附属医院体检中心体检者5870例为研究对象,其中汉族4643例,维吾尔族996例,哈萨克族231例。对体检者进行人体指标测量、血生化指标检测和甲状腺超声检测。结果汉族、维吾尔族和哈萨克族体检者性别、年龄、身高、体质量、体质指数( BMI)、收缩压、舒张压、三酰甘油( TG)、高密度脂蛋白胆固醇( HDL-C)、空腹血糖( FPG)比较,差异均有统计学意义( P <0.05)。3个民族体检者甲状腺结节检出率分别为28.0%(1299/4643)、30.9%(308/996)、39.8%(92/231),差异有统计学意义(χ2=17.309,P<0.001)。3个民族体检者MS检出率分别为16.3%(756/4643)、23.5%(234/996)、22.9%(53/231),差异有统计学意义(χ2=33.596, P<0.001)。汉族体检者中,MS、FPG、血压与甲状腺结节具有关联性(χ2=14.830、19.625、59.757,P <0.05),且随MS相关组分的增加,患甲状腺结节的风险有增高的趋势(χ2趋势=17.195,P<0.05);维吾尔族体检者中,MS、BMI、FPG、血压与甲状腺结节具有关联性(χ2=8.136、14.416、7.707、14.218,P<0.05),且随MS相关组分的增加,患甲状腺结节的风险有增高的趋势(χ2趋势=15.480,P<0.05);哈萨克族体检者中,血压与甲状腺结节具有关联性(χ2=10.745,P<0.05),甲状腺结节患病风险与MS组分无趋势性关系( P=0.612)。Logistic回归分析显示,性别〔OR=3.061,95%CI(2.622,3.573)〕、年龄〔OR=1.046,95%CI(1.040,1.052)〕、血压〔OR=1.217,95%CI(1.036,1.431)〕是汉族患甲状腺结节的危险因素,性别〔OR=2.861,95%CI(2.020,4.053)〕、年龄〔OR=1.077,95%CI(1.061,1.093)〕、BMI〔OR=1.550,95%CI(1.064,2.357)〕是维吾尔族患甲状腺结节的危险因素,性别〔OR =4.401,95%CI(2.068,9.366)〕、年龄〔OR =1.067,95%CI(1.037,1.098)〕、血压〔OR =2.104,95%CI(1.081,4.091)〕是哈萨克族患甲状腺结节的危险因素。结论甲状腺结节与MS及其组分密切相关,不同民族间甲状腺结节患病危险因素不同,应针对不同民族人群甲状腺结节的危险因素采取综合有效的防治措施。
目的:探討漢族、維吾爾族及哈薩剋族甲狀腺結節與代謝綜閤徵( MS)的相關性。方法選取2013年新疆醫科大學第一附屬醫院體檢中心體檢者5870例為研究對象,其中漢族4643例,維吾爾族996例,哈薩剋族231例。對體檢者進行人體指標測量、血生化指標檢測和甲狀腺超聲檢測。結果漢族、維吾爾族和哈薩剋族體檢者性彆、年齡、身高、體質量、體質指數( BMI)、收縮壓、舒張壓、三酰甘油( TG)、高密度脂蛋白膽固醇( HDL-C)、空腹血糖( FPG)比較,差異均有統計學意義( P <0.05)。3箇民族體檢者甲狀腺結節檢齣率分彆為28.0%(1299/4643)、30.9%(308/996)、39.8%(92/231),差異有統計學意義(χ2=17.309,P<0.001)。3箇民族體檢者MS檢齣率分彆為16.3%(756/4643)、23.5%(234/996)、22.9%(53/231),差異有統計學意義(χ2=33.596, P<0.001)。漢族體檢者中,MS、FPG、血壓與甲狀腺結節具有關聯性(χ2=14.830、19.625、59.757,P <0.05),且隨MS相關組分的增加,患甲狀腺結節的風險有增高的趨勢(χ2趨勢=17.195,P<0.05);維吾爾族體檢者中,MS、BMI、FPG、血壓與甲狀腺結節具有關聯性(χ2=8.136、14.416、7.707、14.218,P<0.05),且隨MS相關組分的增加,患甲狀腺結節的風險有增高的趨勢(χ2趨勢=15.480,P<0.05);哈薩剋族體檢者中,血壓與甲狀腺結節具有關聯性(χ2=10.745,P<0.05),甲狀腺結節患病風險與MS組分無趨勢性關繫( P=0.612)。Logistic迴歸分析顯示,性彆〔OR=3.061,95%CI(2.622,3.573)〕、年齡〔OR=1.046,95%CI(1.040,1.052)〕、血壓〔OR=1.217,95%CI(1.036,1.431)〕是漢族患甲狀腺結節的危險因素,性彆〔OR=2.861,95%CI(2.020,4.053)〕、年齡〔OR=1.077,95%CI(1.061,1.093)〕、BMI〔OR=1.550,95%CI(1.064,2.357)〕是維吾爾族患甲狀腺結節的危險因素,性彆〔OR =4.401,95%CI(2.068,9.366)〕、年齡〔OR =1.067,95%CI(1.037,1.098)〕、血壓〔OR =2.104,95%CI(1.081,4.091)〕是哈薩剋族患甲狀腺結節的危險因素。結論甲狀腺結節與MS及其組分密切相關,不同民族間甲狀腺結節患病危險因素不同,應針對不同民族人群甲狀腺結節的危險因素採取綜閤有效的防治措施。
목적:탐토한족、유오이족급합살극족갑상선결절여대사종합정( MS)적상관성。방법선취2013년신강의과대학제일부속의원체검중심체검자5870례위연구대상,기중한족4643례,유오이족996례,합살극족231례。대체검자진행인체지표측량、혈생화지표검측화갑상선초성검측。결과한족、유오이족화합살극족체검자성별、년령、신고、체질량、체질지수( BMI)、수축압、서장압、삼선감유( TG)、고밀도지단백담고순( HDL-C)、공복혈당( FPG)비교,차이균유통계학의의( P <0.05)。3개민족체검자갑상선결절검출솔분별위28.0%(1299/4643)、30.9%(308/996)、39.8%(92/231),차이유통계학의의(χ2=17.309,P<0.001)。3개민족체검자MS검출솔분별위16.3%(756/4643)、23.5%(234/996)、22.9%(53/231),차이유통계학의의(χ2=33.596, P<0.001)。한족체검자중,MS、FPG、혈압여갑상선결절구유관련성(χ2=14.830、19.625、59.757,P <0.05),차수MS상관조분적증가,환갑상선결절적풍험유증고적추세(χ2추세=17.195,P<0.05);유오이족체검자중,MS、BMI、FPG、혈압여갑상선결절구유관련성(χ2=8.136、14.416、7.707、14.218,P<0.05),차수MS상관조분적증가,환갑상선결절적풍험유증고적추세(χ2추세=15.480,P<0.05);합살극족체검자중,혈압여갑상선결절구유관련성(χ2=10.745,P<0.05),갑상선결절환병풍험여MS조분무추세성관계( P=0.612)。Logistic회귀분석현시,성별〔OR=3.061,95%CI(2.622,3.573)〕、년령〔OR=1.046,95%CI(1.040,1.052)〕、혈압〔OR=1.217,95%CI(1.036,1.431)〕시한족환갑상선결절적위험인소,성별〔OR=2.861,95%CI(2.020,4.053)〕、년령〔OR=1.077,95%CI(1.061,1.093)〕、BMI〔OR=1.550,95%CI(1.064,2.357)〕시유오이족환갑상선결절적위험인소,성별〔OR =4.401,95%CI(2.068,9.366)〕、년령〔OR =1.067,95%CI(1.037,1.098)〕、혈압〔OR =2.104,95%CI(1.081,4.091)〕시합살극족환갑상선결절적위험인소。결론갑상선결절여MS급기조분밀절상관,불동민족간갑상선결절환병위험인소불동,응침대불동민족인군갑상선결절적위험인소채취종합유효적방치조시。
Objective To explore the relationship of thyroid nodules( TN)and metabolic syndrome( MS) among Han,Uygur and Kazakh. Methods A cross-sectional study was performed in 5 870 physical examiners(4 643 Han,996 Uygur,231 Kazakh)in the physical examination center of First Teaching Hospital of Xinjiang Medical University in 2013. The subjects had measuring of human indicator,blood biochemical parameters and thyroid ultrasound. Results There was significant difference in gender, age, height, weight, BMI, SBP, DBP, TG, HDL - C, FPG among Han, Uygur, Kazakh ( P <0. 05). The TN detection rate was 28. 0%(1 299/4 643)in Han,30. 9%(308/996)in Uygur,39. 8%(92/231)in Kazakh,the difference was significant(χ2 =17. 309,P <0. 001);MS detection rate was 16. 3%(756/4 643)in Han, 23. 5%(234/996)in Uygur,22. 9%(53/231)in Kazakh,the difference was significant(χ2 =33. 596,P<0. 001). In Han subjects,MS,FPG,blood pressure(BP)were associated with TN(χ2 =14. 830,19. 625,59. 757,P=0. 05),and TN risks increased with the increase of MS component numbers(χ2trend =17. 195,P=0. 05);in Uygur subjects,MS,BMI, FPG,BP were related to TN(χ2 =8. 136,14. 416,7. 707,14. 218,P=0. 05),and TN risks increased with the increase of MS component numbers(χ2trend =15. 480,P=0. 05);in Kazakh subjects,BP related to TN(χ2 =10. 745,P=0. 05),there was no tendency between TN risks and MS component numbers ( P =0. 612 ). Logistic regression analysis showed that gender〔OR=3. 061,95%CI(2. 622,3. 573)〕,age〔OR =1. 046,95%CI(1. 040,1. 052)〕,BP〔OR =1. 217,95%CI (1. 036,1. 431)〕were risk factors of TN in Han;gender〔OR =2. 861,95%CI(2. 020,4. 053)〕,age〔OR =1. 077, 95%CI(1. 061,1. 093)〕,BMI〔OR=1. 550,95%CI(1. 064,2. 357)〕were risk factors of TN in Uygurs;gender〔OR=4. 401,95%CI(2. 068,9. 366)〕,age〔OR =1. 067,95%CI(1. 037,1. 098)〕,BP〔OR =2. 104,95%CI(1. 081, 4. 091)〕were risk factors of TN in Kazakh. Conclusion TN is closely related to MS and its component numbers. Different nationalities have different TN risk factors. Comprehensive,effective measures should be taken to control TN risk factors based on ethnic differences.