心血管病学进展
心血管病學進展
심혈관병학진전
ADVANCES IN CARDIOVASCULAR DISEASES
2015年
4期
519-523
,共5页
秦冉冉(综述)%王志浩(审校)
秦冉冉(綜述)%王誌浩(審校)
진염염(종술)%왕지호(심교)
蛋白质二硫键异构酶%血小板活化%凝血酶%血栓形成%β3 整合素
蛋白質二硫鍵異構酶%血小闆活化%凝血酶%血栓形成%β3 整閤素
단백질이류건이구매%혈소판활화%응혈매%혈전형성%β3 정합소
protein disulfide isomerase%platelet activation%thrombin%thrombosis%β3 integrin
血栓形成可引起心、脑、肺、肾等重要脏器缺血,甚至危及生命。现代凝血理论已证实蛋白质二硫键异构酶在生理性、病理性凝血反应中发挥重要作用。蛋白质二硫键异构酶具有氧化还原、异构化及分子伴侣的作用,能够催化二硫键与巯基之间的互变反应,对参与血栓形成的多种蛋白具有调控作用。近年来关于蛋白质二硫键异构酶对血栓形成调节研究的不断深入,其抑制剂成为抗凝药物研发的新热点。现主要就其作用机制存在的争议展开综述。
血栓形成可引起心、腦、肺、腎等重要髒器缺血,甚至危及生命。現代凝血理論已證實蛋白質二硫鍵異構酶在生理性、病理性凝血反應中髮揮重要作用。蛋白質二硫鍵異構酶具有氧化還原、異構化及分子伴侶的作用,能夠催化二硫鍵與巰基之間的互變反應,對參與血栓形成的多種蛋白具有調控作用。近年來關于蛋白質二硫鍵異構酶對血栓形成調節研究的不斷深入,其抑製劑成為抗凝藥物研髮的新熱點。現主要就其作用機製存在的爭議展開綜述。
혈전형성가인기심、뇌、폐、신등중요장기결혈,심지위급생명。현대응혈이론이증실단백질이류건이구매재생이성、병이성응혈반응중발휘중요작용。단백질이류건이구매구유양화환원、이구화급분자반려적작용,능구최화이류건여구기지간적호변반응,대삼여혈전형성적다충단백구유조공작용。근년래관우단백질이류건이구매대혈전형성조절연구적불단심입,기억제제성위항응약물연발적신열점。현주요취기작용궤제존재적쟁의전개종술。
Thrombosis can cause heart, brain, lung, kidney and other important viscera ischemia, even life-threatening.Modern co-agulation theory has confirmed that protein disulfide isomerase( PDI) in physiological and pathological blood coagulation reaction plays an im-portant role.PDI has three catalytic activities including, thiol-disulfide oxidoreductase, disulfide isomerase and redox-dependent chaperone, to proteins which participate in thrombosis have regulation effect.In recent years,the study of PDI of regulating thrombosis goes deeper, the inhibitors of it has become a new way of antithrombotic drugs.In the present review, we discuss its origin and its specific mechanism.