CAJ | 학술논문

心脏型肌球蛋白结合蛋白C不仅是心肌粗肌丝的主要组成部分，还是参与调节心肌细胞收缩舒张功能的重要物质之一。过去几十年的研究主要集中在心脏型肌球蛋白结合蛋白基因突变致肥厚型心肌病，以及血清心脏型肌球蛋白结合蛋白水平在急性心肌梗死患者的诊断、判断预后作用。近年来对心脏型肌球蛋白结合蛋白C通过磷酸化来调节心肌舒张功能方面有了新进展，而且，多个研究又发现难治性终末期心力衰竭患者的心脏型肌球蛋白结合蛋白磷酸化水平显著降低。这表明心脏型肌球蛋白结合蛋白可能对于舒张功能不全为特征的射血分数保留心力衰竭的发生发展很重要。在这个情况下，现综述总结心脏型肌球蛋白结合蛋白结构和功能的最新研究进展，并对心脏型肌球蛋白结合蛋白与射血分数保留心力衰竭的关系进行简要综述。
심장형기구단백결합단백C불부시심기조기사적주요조성부분，환시삼여조절심기세포수축서장공능적중요물질지일。과거궤십년적연구주요집중재심장형기구단백결합단백기인돌변치비후형심기병，이급혈청심장형기구단백결합단백수평재급성심기경사환자적진단、판단예후작용。근년래대심장형기구단백결합단백C통과린산화래조절심기서장공능방면유료신진전，이차，다개연구우발현난치성종말기심력쇠갈환자적심장형기구단백결합단백린산화수평현저강저。저표명심장형기구단백결합단백가능대우서장공능불전위특정적사혈분수보류심력쇠갈적발생발전흔중요。재저개정황하，현종술총결심장형기구단백결합단백결구화공능적최신연구진전，병대심장형기구단백결합단백여사혈분수보류심력쇠갈적관계진행간요종술。
Cardiac myosin binding protein C ( cMyBP-C) is not only the main part of cardiac thick filament,but a key regulator of car-diac contraction and diastolic function.Early studies have focused on gene variants in cMyBP-C with hypertrophic cardiomyopathy and the value of serum cMyBP-C in the diagnosis and prognosis evaluation of patients with acute myocardial infarction.With the rapid development of medical molecular biology and genomics, studies show that cMyBP-C phosphorylation is directly linked to signaling of diastolic function.More research has found that level of cMyBP-C phosphorylation is significantly decreased during the end-stage heart failure,indicating that cMyBP-C plays an important role in heart failure with preserved ejection fraction( HFpEF).We discusss the latest progress in the structure,function and regulation of cMyBP-C.We also attempt to shed some light on the relationship between the cMyBP-C and HFpEF.