CAJ | 학술논문

Ca2＋-钙调蛋白依赖性蛋白激酶Ⅱ是一种分布广泛的多功能丝氨酸／苏氨酸蛋白激酶，参与调节心脏的多种生理活动，如兴奋-收缩耦联和兴奋-转录耦联等生理过程；然而钙调蛋白依赖性蛋白激酶Ⅱ的持续过度表达会催化激活多种心脏靶蛋白，包括离子通道、Ca2＋稳态蛋白、转录因子等，引起兴奋-收缩耦联、兴奋-转录耦联缺陷，提示钙调蛋白依赖性蛋白激酶Ⅱ信号通路是促进心肌肥厚、心力衰竭和心律失常的中心机制之一。现对近几年来这一领域的进展进行扼要综述。
Ca2＋-개조단백의뢰성단백격매Ⅱ시일충분포엄범적다공능사안산／소안산단백격매，삼여조절심장적다충생리활동，여흥강-수축우련화흥강-전록우련등생리과정；연이개조단백의뢰성단백격매Ⅱ적지속과도표체회최화격활다충심장파단백，포괄리자통도、Ca2＋은태단백、전록인자등，인기흥강-수축우련、흥강-전록우련결함，제시개조단백의뢰성단백격매Ⅱ신호통로시촉진심기비후、심력쇠갈화심률실상적중심궤제지일。현대근궤년래저일영역적진전진행액요종술。
Calcium/calmodulin-dependent kinase Ⅱ( CaMKⅡ) is a widely distributed multifunctional serine/threonine protein ki-nase.It regulates a variety of physiological activities in heart, including excitation-contraction coupling and excitation-transcription coupling.However, persistently overexpression of CaMKⅡ causes the defect of excitation-contraction coupling and excitation-transcription coupling by catalyzing multiple cardiac target proteins, such as ion channels, Ca2+homeostatic proteins and transcription factors, suggesting that CaMKⅡpathway is a core mechanism for promoting myocardial hypertrophy, heart failure and arrhythmias.In this review, we will brief-ly introduce the recent research advance in this area.