CAJ | 학술논문

目的：探讨TNFR1基因多态性与垂体腺瘤侵袭性的相关性。方法采用PCR‐RFLP法分析30名垂体腺瘤患者（实验组）、30例健康体检者（对照组）的TNFR1基因多态性分布，探讨其与垂体腺瘤侵袭性的关系。结果实验组TNFR1－609G、T等位基因分布频率分别为40．0％、66．7％，对照组分别为50．0％、43．3％；T等位基因分布频率实验组显著高于对照组（P＜0．05）。实验组TNFR1＋36A、G等位基因分布频率分别为90．0％、6．7％，对照组分别为93．3％、6．7％；A、G等位基因分布频率两组差异无统计学意义（P＞0．05）。侵袭组TNFR1－609G、T等位基因分布频率分别为41．7％、62．5％，非侵袭组分别为50．0％、33．3％；T等位基因分布频率侵袭组显著高于非侵袭组（P＝0．02）。侵袭组TNFR1＋36A、G等位基因分布频率分别为87．5％、4．2％，非侵袭组分别为83．3％、0％；A、G等位基因分布频率两组差异无统计学意义（P＞0．05）。结论携带TNFR1－609T等位基因可成为侵袭性垂体腺瘤的遗传标志。
목적：탐토TNFR1기인다태성여수체선류침습성적상관성。방법채용PCR‐RFLP법분석30명수체선류환자（실험조）、30례건강체검자（대조조）적TNFR1기인다태성분포，탐토기여수체선류침습성적관계。결과실험조TNFR1－609G、T등위기인분포빈솔분별위40．0％、66．7％，대조조분별위50．0％、43．3％；T등위기인분포빈솔실험조현저고우대조조（P＜0．05）。실험조TNFR1＋36A、G등위기인분포빈솔분별위90．0％、6．7％，대조조분별위93．3％、6．7％；A、G등위기인분포빈솔량조차이무통계학의의（P＞0．05）。침습조TNFR1－609G、T등위기인분포빈솔분별위41．7％、62．5％，비침습조분별위50．0％、33．3％；T등위기인분포빈솔침습조현저고우비침습조（P＝0．02）。침습조TNFR1＋36A、G등위기인분포빈솔분별위87．5％、4．2％，비침습조분별위83．3％、0％；A、G등위기인분포빈솔량조차이무통계학의의（P＞0．05）。결론휴대TNFR1－609T등위기인가성위침습성수체선류적유전표지。
Objective To explore the relationship between TNFR1 gene polymorphisms and aggressiveness of pi‐tuitary adenoma .Method TNF gene polymorphisms were determined by clinical research in 30 patients(experimental group)with pituitary adenoma and 30 healthy controls(control group) .Result The frequencies of TNFR1-609G and T alleles in experimental group were 40 .0% ,66 .7% ,while those in control group were 50 .0% ,43 .3% .The fre‐quencies of TNFR1-609T in experimental group was higher than in control group(P<0 .05) .The frequencies of TNFR1+36 A and G alleles in experimental group were 90 .0% ,6 .7% ,while those in control group were 93 .3% , 6 .7% and there were no statistical significantly differences in TNFR1+36 A and G allele frequency distribution be‐tween both groups(P> 0 .05) .The frequencies of TNFR1 -609G and T alleles in invasive group were 41 .7% , 62 .5% ,while those in non‐invasive group were 50 .0% ,33 .3% .The frequencies of TNFR1-609T in invasive group was higher than in non‐invasive group(P<0 .05) .The frequencies of TNFR1+36 A and G alleles in invasive group were 87 .5% ,4 .2% ,while those in non‐invasive group were 83 .3% ,0% and there were no statistical significantly differences in TNFR1+36 A and G allele frequency distribution between both groups(P>0 .05) .Conclusion TNFR1-609T alleles can be used as a genetic risk marker for the aggressiveness of pituitary adenoma patients .