卒中与神经疾病
卒中與神經疾病
졸중여신경질병
2015年
4期
219-221,225
,共4页
赵云清%罗建华%周其志%汪长英
趙雲清%囉建華%週其誌%汪長英
조운청%라건화%주기지%왕장영
阿司匹林抵抗%动脉粥样硬化%脑梗死%血小板聚集率
阿司匹林牴抗%動脈粥樣硬化%腦梗死%血小闆聚集率
아사필림저항%동맥죽양경화%뇌경사%혈소판취집솔
Aspirin resistance%Atherosclerosis%Cerebral infarction%Platelet aggregation rate
目的：观察阿司匹林抵抗(aspirin resistance,AR)对大动脉粥样硬化性脑梗死(large artery ath-erosclerosis cerebral infarction,LAACI)复发的影响。方法选择阳东县人民医院首次发生 LAACI 患者269例,入院后即服用阿司匹林200mg,在7~10d 后利用比浊法检测血小板聚集率,分为 AR 组40例,阿司匹林敏感组(aspirin sensitivity,AS)229例,进行随访6~12个月；根据脑梗塞复发的情况分为大动脉粥样硬化复发(large artery atherosclerosis recurrence,LAAR)组38例和大动脉粥样硬化无复发(not large artery athero-sclerosis recurrence,NLAAR)组231例,观察 AR 患者的危险因素,同 时 观察 LAAR 与 AR 之间的关系。结果单因素分析中 AR 组的 LAAR 显著高于 AS 组(34.2% vs 11.7%,P =0.000),跟 NLAAR 组比较LAAR 组患糖尿病、AR、年龄较大的比例均明显升高(P <0.05或0.01)；多因素分析中 LAAR 与 AR 明显相关(OR=4.692,95% CI =1.052~15.675,P =0.005)。结论 AR 是 LAAR 的独立危险因素,能够增加LAAR 的风险。
目的：觀察阿司匹林牴抗(aspirin resistance,AR)對大動脈粥樣硬化性腦梗死(large artery ath-erosclerosis cerebral infarction,LAACI)複髮的影響。方法選擇暘東縣人民醫院首次髮生 LAACI 患者269例,入院後即服用阿司匹林200mg,在7~10d 後利用比濁法檢測血小闆聚集率,分為 AR 組40例,阿司匹林敏感組(aspirin sensitivity,AS)229例,進行隨訪6~12箇月；根據腦梗塞複髮的情況分為大動脈粥樣硬化複髮(large artery atherosclerosis recurrence,LAAR)組38例和大動脈粥樣硬化無複髮(not large artery athero-sclerosis recurrence,NLAAR)組231例,觀察 AR 患者的危險因素,同 時 觀察 LAAR 與 AR 之間的關繫。結果單因素分析中 AR 組的 LAAR 顯著高于 AS 組(34.2% vs 11.7%,P =0.000),跟 NLAAR 組比較LAAR 組患糖尿病、AR、年齡較大的比例均明顯升高(P <0.05或0.01)；多因素分析中 LAAR 與 AR 明顯相關(OR=4.692,95% CI =1.052~15.675,P =0.005)。結論 AR 是 LAAR 的獨立危險因素,能夠增加LAAR 的風險。
목적：관찰아사필림저항(aspirin resistance,AR)대대동맥죽양경화성뇌경사(large artery ath-erosclerosis cerebral infarction,LAACI)복발적영향。방법선택양동현인민의원수차발생 LAACI 환자269례,입원후즉복용아사필림200mg,재7~10d 후이용비탁법검측혈소판취집솔,분위 AR 조40례,아사필림민감조(aspirin sensitivity,AS)229례,진행수방6~12개월；근거뇌경새복발적정황분위대동맥죽양경화복발(large artery atherosclerosis recurrence,LAAR)조38례화대동맥죽양경화무복발(not large artery athero-sclerosis recurrence,NLAAR)조231례,관찰 AR 환자적위험인소,동 시 관찰 LAAR 여 AR 지간적관계。결과단인소분석중 AR 조적 LAAR 현저고우 AS 조(34.2% vs 11.7%,P =0.000),근 NLAAR 조비교LAAR 조환당뇨병、AR、년령교대적비례균명현승고(P <0.05혹0.01)；다인소분석중 LAAR 여 AR 명현상관(OR=4.692,95% CI =1.052~15.675,P =0.005)。결론 AR 시 LAAR 적독립위험인소,능구증가LAAR 적풍험。
Objective To observe the influence of aspirin resistance on cerebral infarction recurrence with large artery atherosclerosis and the long-term curative effect of aspirin.Methods We collected 269 pa-tients with ischemic stroke during November 2012 to November 2013 in Department of Neurology of yang-dong People's hospital,all patients took aspirin 200 mg/d ,and then were divided into AR group and aspirin sensitiv-ity(AS)group according to use Turbidimetry to measure the platelet aggregation rate after taking aspirin 7 ~10 d.Depending on the recurrence of cerebral infarction,the patients were divided into the group of large ar-tery atherosclerosis recurrence (LAAR)group (229 cases )and not large artery atherosclerosis recurrence (NLAAR)group(23 1 cases)after following up 6~ 12 months,and observed the risk factors of patients with AR and the relationship between LAAR and AR.Results In single factor analysis,LAAR in AR group was significantly higher than the AS group (vs 1 1 .7% 34.2%,P =0.000).LAAR in patients in LAAR with dia-betes,AR,older were significant different (P < 0.05 or 0.01 ),compared with NLAAR group.In multiple factors analysis,LAAR was significantly related with AR (OR = 4.692,95% CI = 1 .052 ~ 1 5.675,P =0.005).Conclusions AR is independent risk factors of LAAR,and can increase the risk of LAAR.
