CAJ | 학술논문

目的：探讨高迁移率族蛋白B1（HMGB1）在胶质瘤相关性癫痫患者致痫灶组织中的表达及临床意义。方法：利用免疫组化法检测82例胶质瘤相关性癫痫患者的致痫灶组织、胶质瘤组织、瘤周非致痫灶脑组织中HMGB1的表达，分析致痫灶组织中HMGB1表达与临床病理因素的关系。结果：致痫灶、胶质瘤组织中HMGB1的表达高于瘤周非致痫灶脑组织（χ2＝71．000，46．538，P＜0．001）。致痫灶组织中HMGB1的表达与患者性别、年龄及致痫灶位置无关（P＞0．05），而与癫痫持续时间、癫痫发作频率、胶质瘤病理级别有关（χ2＝10．934，23．116，5．764， P＜0．05）。结论：HMGB1可能成为胶质瘤相关性癫痫治疗、预后判断等的新靶点。
목적：탐토고천이솔족단백B1（HMGB1）재효질류상관성전간환자치간조조직중적표체급림상의의。방법：이용면역조화법검측82례효질류상관성전간환자적치간조조직、효질류조직、류주비치간조뇌조직중HMGB1적표체，분석치간조조직중HMGB1표체여림상병리인소적관계。결과：치간조、효질류조직중HMGB1적표체고우류주비치간조뇌조직（χ2＝71．000，46．538，P＜0．001）。치간조조직중HMGB1적표체여환자성별、년령급치간조위치무관（P＞0．05），이여전간지속시간、전간발작빈솔、효질류병리급별유관（χ2＝10．934，23．116，5．764， P＜0．05）。결론：HMGB1가능성위효질류상관성전간치료、예후판단등적신파점。
Aim:To explore expression and clinical significance of high-mobility group box-1 ( HMGB1 ) in epilepto-genic foci tissue of glioma-related epilepsy .Methods:The expression of HMGB1 in epileptogenic foci tissue , glioma tis-sue, non-epileptogenic foci brain tissue around glioma of 82 glioma-related epilepsy patients was detected via immunohisto-chemistry.Results:The expression of HMGB1 in epileptogenic foci tissue and glioma tissue was higher than that in non-ep-ileptogenic foci brain tissue around glioma (χ2 =71.000,46.538,P<0.001).The expression of HMGB1 in epileptogenic foci tissue had no relation with gender , age or location of the epileptogenic foci (P>0.05), but was related with seizure duration,seizure frequence and pathological grade of glioma (χ2 =10.934,23.116,5.764, P <0.05).Conclusion:HMGB1 may become a new target for treatment and the prognosis forecasting of glioma-related epilepsy .