华中科技大学学报(医学版)
華中科技大學學報(醫學版)
화중과기대학학보(의학판)
ACTA UNIVERSITATIS MEDICINAE TONGJI
2015年
4期
488-492
,共5页
吴婷婷%孙开宇%张岑%彭涛%黄铄
吳婷婷%孫開宇%張岑%彭濤%黃鑠
오정정%손개우%장잠%팽도%황삭
尘螨变应原%变应性鼻炎%临床疗效%安全性%M eta分析
塵螨變應原%變應性鼻炎%臨床療效%安全性%M eta分析
진만변응원%변응성비염%림상료효%안전성%M eta분석
dust mite allergen%allergic rhinitis%clinical efficacy%safety%meta-analysis
目的:通过M eta分析的方法对国内应用尘螨变应原免疫治疗变应性鼻炎的临床疗效及安全性进行评价。方法计算机检索维普中文科技期刊全文数据库(1989~2015年)、中国万方数据库(1999~2015年)、中国知网数据库(1994~2015年)、学术期刊网络出版总库中关于尘螨变应原免疫治疗变应性鼻炎的临床随机对照试验(RC T ),对符合要求的RC T进行M eta分析。结果最终纳入16篇RC T ,共有2018例患者符合纳入标准。M eta分析结果显示,与对照组相比,尘螨变应原免疫治疗组临床疗效显著提高[总效应Z=6.67,OR =2.92,95% CI(2.13,4.00),P<0.01],临床症状显著改善[总效应 Z=4.66,SMD=-1.82,95% CI(-2.58,-1.05),P<0.01]及不良反应无增加[总效应 Z=1.99,OR=0.62,95% CI(0.39,0.99),P=0.05]。结论尘螨变应原免疫治疗可明显改善变应性鼻炎的临床症状,其临床疗效确切,且其不增加不良反应的发生,安全性可靠。
目的:通過M eta分析的方法對國內應用塵螨變應原免疫治療變應性鼻炎的臨床療效及安全性進行評價。方法計算機檢索維普中文科技期刊全文數據庫(1989~2015年)、中國萬方數據庫(1999~2015年)、中國知網數據庫(1994~2015年)、學術期刊網絡齣版總庫中關于塵螨變應原免疫治療變應性鼻炎的臨床隨機對照試驗(RC T ),對符閤要求的RC T進行M eta分析。結果最終納入16篇RC T ,共有2018例患者符閤納入標準。M eta分析結果顯示,與對照組相比,塵螨變應原免疫治療組臨床療效顯著提高[總效應Z=6.67,OR =2.92,95% CI(2.13,4.00),P<0.01],臨床癥狀顯著改善[總效應 Z=4.66,SMD=-1.82,95% CI(-2.58,-1.05),P<0.01]及不良反應無增加[總效應 Z=1.99,OR=0.62,95% CI(0.39,0.99),P=0.05]。結論塵螨變應原免疫治療可明顯改善變應性鼻炎的臨床癥狀,其臨床療效確切,且其不增加不良反應的髮生,安全性可靠。
목적:통과M eta분석적방법대국내응용진만변응원면역치료변응성비염적림상료효급안전성진행평개。방법계산궤검색유보중문과기기간전문수거고(1989~2015년)、중국만방수거고(1999~2015년)、중국지망수거고(1994~2015년)、학술기간망락출판총고중관우진만변응원면역치료변응성비염적림상수궤대조시험(RC T ),대부합요구적RC T진행M eta분석。결과최종납입16편RC T ,공유2018례환자부합납입표준。M eta분석결과현시,여대조조상비,진만변응원면역치료조림상료효현저제고[총효응Z=6.67,OR =2.92,95% CI(2.13,4.00),P<0.01],림상증상현저개선[총효응 Z=4.66,SMD=-1.82,95% CI(-2.58,-1.05),P<0.01]급불량반응무증가[총효응 Z=1.99,OR=0.62,95% CI(0.39,0.99),P=0.05]。결론진만변응원면역치료가명현개선변응성비염적림상증상,기림상료효학절,차기불증가불량반응적발생,안전성가고。
Objective To carry out a meta‐analysis on the published data in order to evaluate the clinical efficacy and safety of dust mite allergen vaccine immunotherapy of allergic rhinitis.Methods A comprehensive search was performed in VIP (1989‐2015) ,WANFANG(1999‐2015) ,CNKI(1994‐2015)and CAJD databases to collect the randomized controlled trials (RCTs)relat‐ed to dust mite allergen vaccine immunotherapy of allergic rhinitis ,and to analyze the RCTs in meta‐analysis method.Results In total ,2 018 patients were analyzed in the 16 RCTs which met the inclusion criteria.The meta‐analysis results suggested that , compared with the control group ,patients had better clinical effect [test for overall effect :Z=6.67 ,OR =2.92 ,95% CI(2.13 , 4.00) ,P<0.01] ,more significant improvement in clinical symptoms [test for overall effect :Z= 4.66 ,SMD= -1.82 ,95% CI (-2.58 ,-1.05) ,P<0.01]and no more adverse reactions[test for overall effect :Z=1.99 ,OR=0.62 ,95% CI(0.39 ,0.99) ,P=0.05]in dust mite allergen vaccine immunotherapy group.Conclusion Dust mite allergen vaccine immunotherapy can signifi‐cantly improve the clinical symptoms of allergic rhinitis ,and the clinical effect is positive.In addition ,the adverse reaction was not increased ,so dust mite allergen vaccine immunotherapy is safe for allergic rhinitis.