CAJ | 학술논문

目的：建立稳定的家兔颈静脉导管相关血栓模型，并探讨低分子肝素与地塞米松对其形成的影响。方法将60只日本大耳白兔分为对照组、低分子肝素组、地塞米松组和合用组。将中心静脉导管（CVC ）插入右侧颈静脉制造导管相关血栓动物模型。术后分别给予低分子肝素钠／地塞米松。术后第7天观察颈静脉导管相关血栓形成情况及血浆内D‐D二聚体水平。结果成功建立简便有效的日本大耳白兔导管相关血栓模型。低分子肝素组及合用组实验兔导管相关血栓形成较对照组显著降低，D‐D二聚体水平明显下降（ P＜0.01）。结论应用低分子肝素能有效预防导管相关血栓。糖皮质激素抗炎治疗可能对预防导管相关血栓形成有一定作用。
목적：건립은정적가토경정맥도관상관혈전모형，병탐토저분자간소여지새미송대기형성적영향。방법장60지일본대이백토분위대조조、저분자간소조、지새미송조화합용조。장중심정맥도관（CVC ）삽입우측경정맥제조도관상관혈전동물모형。술후분별급여저분자간소납／지새미송。술후제7천관찰경정맥도관상관혈전형성정황급혈장내D‐D이취체수평。결과성공건립간편유효적일본대이백토도관상관혈전모형。저분자간소조급합용조실험토도관상관혈전형성교대조조현저강저，D‐D이취체수평명현하강（ P＜0.01）。결론응용저분자간소능유효예방도관상관혈전。당피질격소항염치료가능대예방도관상관혈전형성유일정작용。
Objective To investigate the therapeutic effect of low molecular weight heparin sodium and dexamethasone so‐dium phosphate on catheter‐related thrombosis.Methods Sixty Japanese big ear white rabbits were divided into four groups (n=15 each):control group ,low molecular weight heparin group ,dexamethasone sodium phosphate group ,low molecular weight heparin combined with dexamethasone group.A central venous catheter was inserted into right jugular vein to induce catheter‐related thrombosis.After the surgery ,control group was treated with normal saline ;molecular weight heparin group and dexam‐ethasone sodium phosphate group were subcutaneously injected with low molecular weight heparin and dexamethasone ,respec‐tively ;low molecular weight heparin combined with dexamethasone group received injection of both.Catheter‐related thrombosis in jugular vein and D‐Dimer concentration in serum were observed 7 days after the surgery.Results Catheter‐related thrombo‐sis model was successfully established in Japanese big ear white rabbits.Compared with control group ,the formation rates of catheter‐related thrombosis in low molecular weight heparin group and low molecular weight heparin combined with dexametha‐sone group were significantly decreased (P<0.01) ,and the levels of D‐dimer were significantly decreased in these groups (P<0.01).Conclusion Low molecular weight heparin may prevent catheter‐related thrombosis efficiently.Anti‐inflammation treat‐ment with glucocorticoid might inhibit catheter‐related thrombosis.