CAJ | 학술논문

目的：研究肝静脉压力梯度（HVPG）与肝硬化患者临床特征与实验室结果的相关性。方法纳入2012年12月至2014年4月间接受 HVPG 测定的肝硬化患者，收集这些患者的肝硬化病因，白蛋白、肌酐、总胆红素水平，INR ，是否存在腹水及出血，内镜下食管静脉曲张程度，Child‐Pugh 分级及终末期肝病模型评分等资料。采用单因素及多因素线性回归的方法，研究这些指标与 HVPG 水平间的相关性。结果63例肝硬化患者符合纳入条件，其中6例存在肝静脉的异常分流，HVPG 测定失败。余57例患者的 HVPG 为9．50～33．20 mmHg （1 mmHg ＝0．133 kPa ），平均为（16．38±5．64） mmHg 。单因素回归分析显示，57例患者的白蛋白水平（r2＝0．145，P＝0．002）和 Child‐Pugh 分级（r2＝0．069，P＝0．048）与 HVPG 水平的相关性有统计学意义。多因素分析显示，白蛋白（B ＝－4．920， t＝－3．521，P＝0．001）及总胆红素水平（B＝4．066，t＝2．206，P ＝0．032）与 HVPG 水平的相关性有统计学意义，其余指标与 HVPG 水平无相关性。结论肝硬化患者白蛋白与总胆红素水平与 HVPG 水平相关。
목적：연구간정맥압력제도（HVPG）여간경화환자림상특정여실험실결과적상관성。방법납입2012년12월지2014년4월간접수 HVPG 측정적간경화환자，수집저사환자적간경화병인，백단백、기항、총담홍소수평，INR ，시부존재복수급출혈，내경하식관정맥곡장정도，Child‐Pugh 분급급종말기간병모형평분등자료。채용단인소급다인소선성회귀적방법，연구저사지표여 HVPG 수평간적상관성。결과63례간경화환자부합납입조건，기중6례존재간정맥적이상분류，HVPG 측정실패。여57례환자적 HVPG 위9．50～33．20 mmHg （1 mmHg ＝0．133 kPa ），평균위（16．38±5．64） mmHg 。단인소회귀분석현시，57례환자적백단백수평（r2＝0．145，P＝0．002）화 Child‐Pugh 분급（r2＝0．069，P＝0．048）여 HVPG 수평적상관성유통계학의의。다인소분석현시，백단백（B ＝－4．920， t＝－3．521，P＝0．001）급총담홍소수평（B＝4．066，t＝2．206，P ＝0．032）여 HVPG 수평적상관성유통계학의의，기여지표여 HVPG 수평무상관성。결론간경화환자백단백여총담홍소수평여 HVPG 수평상관。
Objective To investigate the correlation between hepatic venous pressure gradient (HVPG) and clinic features ,laboratory results in patients with liver cirrhosis .Methods From December 2012 to April 2014 ,patients with liver cirrhosis who received HVPG examination were enrolled .The clinical data of the patients were collected ,which included etiology of cirrhosis ,albumin ,creatine ,total bilirubin ,international normal ratio (INR) ,history of ascite and bleeding ,degree of gastroesophageal varices under endoscopy ,the scores of Child‐Pugh and model for end‐stage liver disease (MELD) .Single factor and multiple factor linear regression method were performed to analyze the correlation between these indexes and HVPG .Results A total of 63 patients met the inclusion criteria .Among them ,six patients had abnormal shunt in liver venous and HVPG examination failed .The HVPG of the left 57 patients was 9 .50 to 33 .20 mmHg (1 mmHg = 0 .133 kPa) ,mean (16 .38 ± 5 .64) mmHg .The results of single factor regression analysis indicated that there were certain relevance between the level of albumin (r2 = 0 .145 , P= 0 .002) ,Child‐Pugh score (r2 = 0 .069 ,P= 0 .048) and HVPG .Multiple factor analysis indicated that there were certain relevance between albumin (B= - 4 .920 ,t= - 3 .521 ,P= 0 .001) ,total bilirubin (B =4 .066 ,t= 2 .206 ,P = 0 .032) and HVPG ,and there were no relevance between the other indexes and HVPG .Conclusion Only albumin and total bilirubin level in patients with liver cirrhosis are correlated with the level of HVPG .